AU2013255666A1 - Antiretroviral composition - Google Patents
Antiretroviral composition Download PDFInfo
- Publication number
- AU2013255666A1 AU2013255666A1 AU2013255666A AU2013255666A AU2013255666A1 AU 2013255666 A1 AU2013255666 A1 AU 2013255666A1 AU 2013255666 A AU2013255666 A AU 2013255666A AU 2013255666 A AU2013255666 A AU 2013255666A AU 2013255666 A1 AU2013255666 A1 AU 2013255666A1
- Authority
- AU
- Australia
- Prior art keywords
- solid oral
- pharmaceutical solid
- composition according
- polymer
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 230
- 230000000798 anti-retroviral effect Effects 0.000 title claims abstract description 73
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- 229940079593 drug Drugs 0.000 claims abstract description 115
- 238000004519 manufacturing process Methods 0.000 claims abstract description 23
- 208000030507 AIDS Diseases 0.000 claims abstract description 16
- 208000031886 HIV Infections Diseases 0.000 claims abstract description 15
- 238000011282 treatment Methods 0.000 claims abstract description 13
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- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims description 86
- 229920000642 polymer Polymers 0.000 claims description 72
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- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims description 66
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- NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 claims description 6
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- 239000003112 inhibitor Substances 0.000 claims description 5
- 229940124524 integrase inhibitor Drugs 0.000 claims description 5
- 239000002850 integrase inhibitor Substances 0.000 claims description 5
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- 229920003109 sodium starch glycolate Polymers 0.000 claims description 5
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- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 4
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- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 3
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- GWFOVSGRNGAGDL-FSDSQADBSA-N 2-amino-9-[(1r,2r,3s)-2,3-bis(hydroxymethyl)cyclobutyl]-3h-purin-6-one Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1C[C@H](CO)[C@H]1CO GWFOVSGRNGAGDL-FSDSQADBSA-N 0.000 claims description 3
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- UXCAQJAQSWSNPQ-XLPZGREQSA-N Alovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](F)C1 UXCAQJAQSWSNPQ-XLPZGREQSA-N 0.000 claims description 3
- AXRYRYVKAWYZBR-UHFFFAOYSA-N Atazanavir Natural products C=1C=C(C=2N=CC=CC=2)C=CC=1CN(NC(=O)C(NC(=O)OC)C(C)(C)C)CC(O)C(NC(=O)C(NC(=O)OC)C(C)(C)C)CC1=CC=CC=C1 AXRYRYVKAWYZBR-UHFFFAOYSA-N 0.000 claims description 3
- 108010019625 Atazanavir Sulfate Proteins 0.000 claims description 3
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 claims description 3
- XPOQHMRABVBWPR-UHFFFAOYSA-N Efavirenz Natural products O1C(=O)NC2=CC=C(Cl)C=C2C1(C(F)(F)F)C#CC1CC1 XPOQHMRABVBWPR-UHFFFAOYSA-N 0.000 claims description 3
- XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 claims description 3
- WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 claims description 3
- RLAHNGKRJJEIJL-RFZPGFLSSA-N [(2r,4r)-4-(2,6-diaminopurin-9-yl)-1,3-dioxolan-2-yl]methanol Chemical compound C12=NC(N)=NC(N)=C2N=CN1[C@H]1CO[C@@H](CO)O1 RLAHNGKRJJEIJL-RFZPGFLSSA-N 0.000 claims description 3
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- MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 claims description 3
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- A—HUMAN NECESSITIES
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1380MU2012 | 2012-05-03 | ||
| IN1380/MUM/2012 | 2012-05-03 | ||
| IN2590MU2012 | 2012-09-06 | ||
| IN2590/MUM/2012 | 2012-09-06 | ||
| PCT/GB2013/000193 WO2013164559A1 (en) | 2012-05-03 | 2013-05-03 | Antiretroviral composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2013255666A1 true AU2013255666A1 (en) | 2014-11-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013255666A Abandoned AU2013255666A1 (en) | 2012-05-03 | 2013-05-03 | Antiretroviral composition |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20150086628A1 (OSRAM) |
| EP (1) | EP2844231A1 (OSRAM) |
| JP (1) | JP6314131B2 (OSRAM) |
| KR (1) | KR20150021510A (OSRAM) |
| CN (1) | CN104411300A (OSRAM) |
| AU (1) | AU2013255666A1 (OSRAM) |
| CA (1) | CA2871794A1 (OSRAM) |
| IN (1) | IN2014MN02252A (OSRAM) |
| JO (1) | JO3641B1 (OSRAM) |
| MX (1) | MX2014013326A (OSRAM) |
| RU (1) | RU2014148964A (OSRAM) |
| WO (1) | WO2013164559A1 (OSRAM) |
| ZA (1) | ZA201408281B (OSRAM) |
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| RU2663466C1 (ru) * | 2017-03-20 | 2018-08-06 | Общество с ограниченной ответственностью "МБА-групп" | Композиция для профилактики и/или лечения вич-инфекции |
| CN112220771B (zh) * | 2020-11-10 | 2023-03-31 | 成都大学 | 扎西他滨渗透泵型控释片及其制备方法 |
| US20250242031A1 (en) * | 2022-02-14 | 2025-07-31 | Purdue Research Foundation | Polymer salts for improved drug delivery from amorphous solid dispersions |
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| NZ226822A (en) * | 1987-11-16 | 1990-03-27 | Mcneil Consumer Prod | Chewable medicament tablet containing means for taste masking |
| US5696270A (en) | 1989-05-23 | 1997-12-09 | Abbott Laboratories | Intermediate for making retroviral protease inhibiting compounds |
| IL110752A (en) | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
| JP3693270B2 (ja) * | 1995-10-12 | 2005-09-07 | 旭化成ケミカルズ株式会社 | フィルムコーティング顆粒およびその製造方法 |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| ZA9710071B (en) | 1996-11-21 | 1998-05-25 | Abbott Lab | Pharmaceutical composition. |
| MXPA03010771A (es) | 2001-05-25 | 2004-07-01 | Abbott Lab | Capsulas elasticas blandas que comprenden ritonavir y/o lopinavir. |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| BRPI0507372A (pt) * | 2004-02-06 | 2007-07-10 | Wyeth Corp | formulação de multiparticulados de um o-desmetilvenlafaxina (odv), métodos para tratar de depressão em um paciente em sua necessidade e para reduzir os efeitos colaterais gastrintestinais da venlafaxina em um paciente, formulação de liberação modificada de um multiparticulado, método para reduzir os efeitos colaterais gastrintestinais de um odv em um paciente, produto de venlafaxina de liberação modificada, métodos para reduzir os efeitos colaterais gastrintestinais associados com o tratamento da venlafaxina e para liberar odv a um paciente pediátrico ou geriátrico, formulações de multiparticulados de formiato ou succinato de odv e de liberação retardada de formiato ou succinato de odv, uso de uma formulação, e, pacote farmacêutico |
| MXPA06010488A (es) * | 2004-03-31 | 2006-12-19 | Bpsi Holdings Inc | Revestimientos entericos para sustratos oralmente ingeribles. |
| US20100173921A1 (en) * | 2006-08-10 | 2010-07-08 | Cipla Limited | Antiretroviral Solid Oral Composition |
| CA2707418C (en) * | 2007-11-16 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| PA8809601A1 (es) * | 2007-12-24 | 2009-07-23 | Cipla Ltd | Combinación anti-retroviral |
| WO2009153654A1 (en) * | 2008-06-17 | 2009-12-23 | Aurobindo Pharma Limited | Solid dosage forms of antiretrovirals |
| EP2568964B1 (en) * | 2010-05-10 | 2018-08-01 | Evonik Röhm GmbH | Pharmaceutical dosage form comprising one or more antiretroviral active ingredients |
| WO2013057469A1 (en) * | 2011-10-20 | 2013-04-25 | Cipla Limited | Pharmaceutical antiretroviral compositions |
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2013
- 2013-05-03 AU AU2013255666A patent/AU2013255666A1/en not_active Abandoned
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- 2013-05-03 EP EP13723897.8A patent/EP2844231A1/en not_active Withdrawn
- 2013-05-03 CA CA2871794A patent/CA2871794A1/en not_active Abandoned
- 2013-05-03 US US14/398,178 patent/US20150086628A1/en not_active Abandoned
- 2013-05-05 JO JOP/2013/0141A patent/JO3641B1/ar active
-
2014
- 2014-11-12 ZA ZA2014/08281A patent/ZA201408281B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2871794A1 (en) | 2013-11-07 |
| JO3641B1 (ar) | 2020-08-27 |
| EP2844231A1 (en) | 2015-03-11 |
| JP2015519326A (ja) | 2015-07-09 |
| WO2013164559A1 (en) | 2013-11-07 |
| IN2014MN02252A (OSRAM) | 2015-07-24 |
| JP6314131B2 (ja) | 2018-04-18 |
| US20150086628A1 (en) | 2015-03-26 |
| ZA201408281B (en) | 2019-06-26 |
| RU2014148964A (ru) | 2016-06-27 |
| KR20150021510A (ko) | 2015-03-02 |
| MX2014013326A (es) | 2015-08-10 |
| CN104411300A (zh) | 2015-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |