AU2013255612B2 - Pyrrolobenzodiazepines - Google Patents

Pyrrolobenzodiazepines Download PDF

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Publication number
AU2013255612B2
AU2013255612B2 AU2013255612A AU2013255612A AU2013255612B2 AU 2013255612 B2 AU2013255612 B2 AU 2013255612B2 AU 2013255612 A AU2013255612 A AU 2013255612A AU 2013255612 A AU2013255612 A AU 2013255612A AU 2013255612 B2 AU2013255612 B2 AU 2013255612B2
Authority
AU
Australia
Prior art keywords
compound according
nme
group
methyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013255612A
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English (en)
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AU2013255612A1 (en
Inventor
Philip Wilson Howard
Khondaker Mirazur RAHMAN
Peter William Taylor
David Edwin Thurston
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MedImmune Ltd
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MedImmune Ltd
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Publication of AU2013255612A1 publication Critical patent/AU2013255612A1/en
Assigned to UCL BUSINESS PLC, MEDIMMUNE LIMITED reassignment UCL BUSINESS PLC Request for Assignment Assignors: SPIROGEN SARL, UCL BUSINESS PLC
Assigned to MEDIMMUNE LIMITED reassignment MEDIMMUNE LIMITED Request for Assignment Assignors: MEDIMMUNE LIMITED, UCL BUSINESS PLC
Application granted granted Critical
Publication of AU2013255612B2 publication Critical patent/AU2013255612B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2013255612A 2012-04-30 2013-04-30 Pyrrolobenzodiazepines Ceased AU2013255612B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261640316P 2012-04-30 2012-04-30
US61/640,316 2012-04-30
PCT/GB2013/051097 WO2013164592A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (2)

Publication Number Publication Date
AU2013255612A1 AU2013255612A1 (en) 2014-11-20
AU2013255612B2 true AU2013255612B2 (en) 2017-06-22

Family

ID=48289484

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013255612A Ceased AU2013255612B2 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Country Status (14)

Country Link
US (1) US9321774B2 (OSRAM)
EP (1) EP2855481A1 (OSRAM)
JP (1) JP6125614B2 (OSRAM)
KR (1) KR101960130B1 (OSRAM)
CN (1) CN104540827B (OSRAM)
AU (1) AU2013255612B2 (OSRAM)
BR (1) BR112014027190B1 (OSRAM)
CA (1) CA2872205C (OSRAM)
HK (1) HK1208217A1 (OSRAM)
IN (1) IN2014MN02175A (OSRAM)
MX (1) MX2014013144A (OSRAM)
NZ (1) NZ701478A (OSRAM)
WO (1) WO2013164592A1 (OSRAM)
ZA (1) ZA201408043B (OSRAM)

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US10526294B2 (en) 2016-06-24 2020-01-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
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GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
WO2018192944A1 (en) 2017-04-18 2018-10-25 Medimmune Limited Pyrrolobenzodiazepine conjugates
CA3057748A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
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WO2019104289A1 (en) 2017-11-27 2019-05-31 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
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GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201900929D0 (en) * 2019-01-23 2019-03-13 King S College London Nf-kappa b inhibitors
MX2021010477A (es) 2019-03-15 2021-10-01 Medimmune Ltd Dimeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento de cancer.
EP4086268A4 (en) 2019-12-31 2024-08-21 LegoChem Biosciences, Inc. PYRROLOBENZODIAZEPINE DERIVATIVE AND LIGAND-LINKER CONJUGATE THEREOF
GB2597532A (en) * 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
EP4548932A1 (en) 2022-06-30 2025-05-07 Toray Industries, Inc. Pharmaceutical composition for treating and/or preventing cancer
KR20250135788A (ko) 2022-12-14 2025-09-15 페온 테라퓨틱스 리미티드 세포독성 화합물

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Also Published As

Publication number Publication date
CN104540827A (zh) 2015-04-22
CN104540827B (zh) 2018-03-23
IN2014MN02175A (OSRAM) 2015-08-28
US20150126495A1 (en) 2015-05-07
CA2872205A1 (en) 2013-11-07
BR112014027190A2 (pt) 2017-06-27
KR101960130B1 (ko) 2019-03-19
JP2015516987A (ja) 2015-06-18
KR20150014935A (ko) 2015-02-09
BR112014027190B1 (pt) 2020-03-03
US9321774B2 (en) 2016-04-26
WO2013164592A1 (en) 2013-11-07
AU2013255612A1 (en) 2014-11-20
ZA201408043B (en) 2017-08-30
CA2872205C (en) 2020-07-21
JP6125614B2 (ja) 2017-05-10
MX2014013144A (es) 2015-05-11
HK1208217A1 (en) 2016-02-26
EP2855481A1 (en) 2015-04-08
NZ701478A (en) 2016-08-26

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Owner name: UCL BUSINESS PLC; MEDIMMUNE LIMITED

Free format text: FORMER APPLICANT(S): SPIROGEN SARL; UCL BUSINESS PLC

PC1 Assignment before grant (sect. 113)

Owner name: MEDIMMUNE LIMITED

Free format text: FORMER APPLICANT(S): MEDIMMUNE LIMITED; UCL BUSINESS PLC

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired