AU2013235275B2 - Methods of treating cancer using aurora kinase inhibitors - Google Patents

Methods of treating cancer using aurora kinase inhibitors Download PDF

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Publication number
AU2013235275B2
AU2013235275B2 AU2013235275A AU2013235275A AU2013235275B2 AU 2013235275 B2 AU2013235275 B2 AU 2013235275B2 AU 2013235275 A AU2013235275 A AU 2013235275A AU 2013235275 A AU2013235275 A AU 2013235275A AU 2013235275 B2 AU2013235275 B2 AU 2013235275B2
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Australia
Prior art keywords
aurora
kinase
cancer
paclitaxel
agents
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AU2013235275A
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AU2013235275A1 (en
Inventor
Arijit CHAKRAVARTY
Jeffrey A. Ecsedy
Robert W. Kleinfield
Kha N. Le
Wen Chyi Shyu
Karthik VENKATAKRISHNAN
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013235275A 2012-03-20 2013-03-19 Methods of treating cancer using aurora kinase inhibitors Active AU2013235275B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261613258P 2012-03-20 2012-03-20
US61/613,258 2012-03-20
PCT/US2013/032962 WO2013142491A1 (en) 2012-03-20 2013-03-19 Methods of treating cancer using aurora kinase inhibitors

Publications (2)

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AU2013235275A1 AU2013235275A1 (en) 2014-10-23
AU2013235275B2 true AU2013235275B2 (en) 2017-12-07

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AU2013235275A Active AU2013235275B2 (en) 2012-03-20 2013-03-19 Methods of treating cancer using aurora kinase inhibitors

Country Status (24)

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US (2) US20130303519A1 (OSRAM)
EP (1) EP2827855B1 (OSRAM)
JP (1) JP6373252B2 (OSRAM)
KR (1) KR102128866B1 (OSRAM)
CN (1) CN104271129A (OSRAM)
AU (1) AU2013235275B2 (OSRAM)
CA (1) CA2868024A1 (OSRAM)
EA (1) EA036434B1 (OSRAM)
ES (1) ES2746946T3 (OSRAM)
GE (1) GEP20186900B (OSRAM)
IL (1) IL234686B (OSRAM)
IN (1) IN2014DN08477A (OSRAM)
JO (1) JO3630B1 (OSRAM)
MA (1) MA37438A1 (OSRAM)
MX (1) MX358411B (OSRAM)
MY (1) MY175225A (OSRAM)
NZ (1) NZ700744A (OSRAM)
PH (1) PH12014502109A1 (OSRAM)
SG (2) SG10201607741RA (OSRAM)
TN (1) TN2014000387A1 (OSRAM)
TW (1) TWI649082B (OSRAM)
UA (1) UA117455C2 (OSRAM)
WO (1) WO2013142491A1 (OSRAM)
ZA (1) ZA201407551B (OSRAM)

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* Cited by examiner, † Cited by third party
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US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
WO2016106357A1 (en) * 2014-12-23 2016-06-30 Millennnium Pharmaceuticals, Inc. Combination of raf inhibitors and aurora kinase inhibitors
EP3317427B1 (en) * 2015-07-02 2020-12-23 Millennium Pharmaceuticals, Inc. Biomarkers of response to selective inhibitors of aurora a kinase
CN114681455A (zh) * 2018-08-17 2022-07-01 深圳微芯生物科技股份有限公司 组蛋白去乙酰化酶抑制剂与蛋白激酶抑制剂之组合及其制药用途

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Also Published As

Publication number Publication date
GEP20186900B (en) 2018-10-10
US20130303519A1 (en) 2013-11-14
ZA201407551B (en) 2019-01-30
TN2014000387A1 (en) 2015-12-21
JP2015510945A (ja) 2015-04-13
PH12014502109A1 (en) 2014-12-10
SG10201607741RA (en) 2016-11-29
HK1206253A1 (en) 2016-01-08
MA37438A1 (fr) 2016-05-31
IN2014DN08477A (OSRAM) 2015-05-08
US10213436B2 (en) 2019-02-26
CN104271129A (zh) 2015-01-07
MY175225A (en) 2020-06-16
EA201491727A1 (ru) 2015-01-30
JO3630B1 (ar) 2020-08-27
ES2746946T3 (es) 2020-03-09
TW201343169A (zh) 2013-11-01
IL234686A0 (en) 2014-11-30
EA036434B1 (ru) 2020-11-10
KR102128866B1 (ko) 2020-07-01
NZ700744A (en) 2016-09-30
IL234686B (en) 2020-01-30
SG11201405621UA (en) 2014-10-30
KR20140144215A (ko) 2014-12-18
WO2013142491A1 (en) 2013-09-26
MX358411B (es) 2018-08-20
AU2013235275A1 (en) 2014-10-23
JP6373252B2 (ja) 2018-08-15
TWI649082B (zh) 2019-02-01
EP2827855A1 (en) 2015-01-28
EP2827855B1 (en) 2019-06-26
MX2014011324A (es) 2014-12-05
US20160193224A1 (en) 2016-07-07
UA117455C2 (uk) 2018-08-10
CA2868024A1 (en) 2013-09-26

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