AU2013234080B2 - Novel pharmaceutical formulations - Google Patents
Novel pharmaceutical formulations Download PDFInfo
- Publication number
- AU2013234080B2 AU2013234080B2 AU2013234080A AU2013234080A AU2013234080B2 AU 2013234080 B2 AU2013234080 B2 AU 2013234080B2 AU 2013234080 A AU2013234080 A AU 2013234080A AU 2013234080 A AU2013234080 A AU 2013234080A AU 2013234080 B2 AU2013234080 B2 AU 2013234080B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- formula
- lactose
- magnesium stearate
- stearic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 65
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 118
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 69
- 239000008101 lactose Substances 0.000 claims abstract description 69
- 150000003839 salts Chemical class 0.000 claims abstract description 69
- 229910052751 metal Inorganic materials 0.000 claims abstract description 64
- 239000002184 metal Substances 0.000 claims abstract description 64
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 59
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 43
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 43
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000008117 stearic acid Substances 0.000 claims abstract description 43
- 239000004480 active ingredient Substances 0.000 claims abstract description 33
- MHQJUHSHQGQVTM-HNENSFHCSA-N Octadecyl fumarate Chemical class CCCCCCCCCCCCCCCCCCOC(=O)\C=C/C(O)=O MHQJUHSHQGQVTM-HNENSFHCSA-N 0.000 claims abstract description 22
- 229940071138 stearyl fumarate Drugs 0.000 claims abstract description 22
- 239000003381 stabilizer Substances 0.000 claims abstract description 19
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 13
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- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical group O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims description 7
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 4
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- UBLOHCIYTDRGJH-UHFFFAOYSA-N 6-[2-[[4-amino-3-(3-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-3-[(2-chlorophenyl)methyl]-4-oxoquinazolin-5-yl]-n,n-bis(2-methoxyethyl)hex-5-ynamide Chemical compound C=1C=CC=C(Cl)C=1CN1C(=O)C=2C(C#CCCCC(=O)N(CCOC)CCOC)=CC=CC=2N=C1CN(C1=NC=NC(N)=C11)N=C1C1=CC=CC(O)=C1 UBLOHCIYTDRGJH-UHFFFAOYSA-N 0.000 abstract 1
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- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 4
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 4
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- GUSBTGLOEAEOHY-UHFFFAOYSA-N 3-[3-[tert-butyl(dimethyl)silyl]oxyphenyl]-2h-pyrazolo[3,4-d]pyrimidin-4-amine Chemical compound CC(C)(C)[Si](C)(C)OC1=CC=CC(C=2C3=C(N)N=CN=C3NN=2)=C1 GUSBTGLOEAEOHY-UHFFFAOYSA-N 0.000 description 3
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| UY33337A (es) | 2010-10-18 | 2011-10-31 | Respivert Ltd | DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS |
| KR20140131971A (ko) | 2012-03-13 | 2014-11-14 | 레스피버트 리미티드 | 신규 약학 제제 |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN104870017B (zh) | 2012-11-08 | 2020-08-14 | 理森制药股份公司 | 含有PDE4抑制剂和PI3δ或双重PI3δ-γ激酶抑制剂的药物组合物 |
| AR095353A1 (es) | 2013-03-15 | 2015-10-07 | Respivert Ltd | Compuesto |
| JO3279B1 (ar) | 2013-03-15 | 2018-09-16 | Respivert Ltd | مشتقات 2-((4- امينو -3- (3- فلورو-5- هيدروكسي فينيل)-h1- بيرازولو [d-3,4] بيرمدين-1-يل )ميثيل )- 3- (2- تراي فلورو ميثيل ) بينزيل ) كوينازولين -4 (h3)- واحد واستخدامها كمثبطات فوسفواينوسيتايد 3- كاينيز |
| MX389256B (es) | 2013-10-04 | 2025-03-20 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos. |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EA201691872A1 (ru) | 2014-03-19 | 2017-04-28 | Инфинити Фармасьютикалз, Инк. | Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств |
| US9944639B2 (en) | 2014-07-04 | 2018-04-17 | Lupin Limited | Quinolizinone derivatives as PI3K inhibitors |
| TR201818680T4 (tr) * | 2014-07-09 | 2019-01-21 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | İnhalasyona yönelik formülasyonların hazırlanması için bir proses. |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN108349985A (zh) | 2015-09-14 | 2018-07-31 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
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| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
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| DK1131059T3 (da) | 1998-11-13 | 2003-06-30 | Jago Res Ag | Tørpulver til inhalation |
| DE1140938T1 (de) | 1999-01-11 | 2003-01-09 | Princeton University, Princeton | Kinase-inhibitoren mit hoher affinität zur ziel detektion und ihre verwendung |
| EP1158958B1 (en) | 1999-03-05 | 2007-06-06 | CHIESI FARMACEUTICI S.p.A. | Improved powdery pharmaceutical compositions for inhalation |
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