AU2013202768B2 - Treatment of cancer with TOR kinase inhibitors - Google Patents
Treatment of cancer with TOR kinase inhibitors Download PDFInfo
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- AU2013202768B2 AU2013202768B2 AU2013202768A AU2013202768A AU2013202768B2 AU 2013202768 B2 AU2013202768 B2 AU 2013202768B2 AU 2013202768 A AU2013202768 A AU 2013202768A AU 2013202768 A AU2013202768 A AU 2013202768A AU 2013202768 B2 AU2013202768 B2 AU 2013202768B2
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- substituted
- pyrazin
- unsubstituted
- tor kinase
- methyl
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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Landscapes
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| EP2945636B1 (en) | 2013-01-16 | 2017-06-28 | Signal Pharmaceuticals, LLC | Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith |
| US9737535B2 (en) | 2014-04-16 | 2017-08-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted pyrazino[2,3-b]pyrazines |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| AU2015289929A1 (en) | 2014-07-14 | 2017-03-02 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
| JP6964343B2 (ja) * | 2015-11-20 | 2021-11-10 | フォーマ セラピューティクス，インコーポレイテッド | ユビキチン特異的プロテアーゼ１阻害剤としてのプリノン |
| EP3641772B1 (en) | 2017-06-22 | 2023-08-02 | Celgene Corporation | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
| CN110403943B (zh) * | 2019-08-19 | 2022-05-17 | 陕西科技大学 | Cc-115在制备抗真菌药物中的应用及其药物组合物 |
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| WO2010044893A1 (en) * | 2008-10-17 | 2010-04-22 | Merck & Co. | Combination therapy |
| WO2011053518A1 (en) * | 2009-10-26 | 2011-05-05 | Signal Pharmaceuticals, Llc | Methods of synthesis and purification of heteroaryl compounds |
| US8110578B2 (en) * | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| US20120238562A1 (en) * | 2011-03-09 | 2012-09-20 | Cedars-Sinai Medical Center | Treatment of cancer by targeting molecules that influence mst1/stk4 signaling |
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| CN1159582C (zh) * | 2001-12-08 | 2004-07-28 | 云南大学 | 一种人体全血或血清总前列腺特征性抗原值，总前列腺特征性抗原灰区值检测方法 |
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