AU2012352454A1 - Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors - Google Patents

Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors Download PDF

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Publication number
AU2012352454A1
AU2012352454A1 AU2012352454A AU2012352454A AU2012352454A1 AU 2012352454 A1 AU2012352454 A1 AU 2012352454A1 AU 2012352454 A AU2012352454 A AU 2012352454A AU 2012352454 A AU2012352454 A AU 2012352454A AU 2012352454 A1 AU2012352454 A1 AU 2012352454A1
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light
tumor
antibody
cells
composition
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Yang-Xin Fu
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University of Chicago
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University of Chicago
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    • C07K14/575Hormones
    • C07K14/62Insulins
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    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/191Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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AU2012352454A 2011-12-15 2012-12-11 Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors Abandoned AU2012352454A1 (en)

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US201161576222P 2011-12-15 2011-12-15
US61/576,222 2011-12-15
PCT/US2012/069013 WO2013090293A1 (en) 2011-12-15 2012-12-11 Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors

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EP (1) EP2790730B1 (enExample)
JP (2) JP2015501839A (enExample)
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AU (1) AU2012352454A1 (enExample)
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WO (1) WO2013090293A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2858876A1 (en) 2011-12-15 2013-06-20 The University Of Chicago Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors
WO2014157692A1 (ja) 2013-03-29 2014-10-02 大日本住友製薬株式会社 Wt1抗原ペプチドコンジュゲートワクチン
US11000603B2 (en) 2015-04-14 2021-05-11 Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. Multi-specific binding conjugate, related pharmaceutical compositions and use
US20180140691A1 (en) * 2015-05-20 2018-05-24 Sumitomo Dainippon Pharma Co., Ltd. Combination use of wt1 antigen peptide and immunomodulator
WO2017049232A1 (en) * 2015-09-18 2017-03-23 The General Hospital Corporation Dba Massachusetts General Hospital Compositions having anti-fugetactic properties for treatment of cancer
EP3450460B1 (en) * 2016-04-29 2023-07-12 Benhealth Biopharmaceutic (Shenzhen) Co. Ltd. Multi-specific binding conjugate, related pharmaceutical compositions and use
EP3502142B1 (en) 2016-06-22 2021-10-27 Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. Bispecific antibody and antibody conjugate for tumour therapy and use thereof
CN106701825A (zh) * 2016-11-17 2017-05-24 中国科学院生物物理研究所 腺病毒疫苗Ad‑LIGHT‑HBsAg及其用于治疗慢性乙肝的用途
WO2018101309A1 (ja) 2016-11-30 2018-06-07 大日本住友製薬株式会社 Wt1ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ
AU2018221254B2 (en) * 2017-02-17 2025-03-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fat-associated lymphoid clusters as sites for transplantation, tissue regeneration, organogenesis and function for multiple tissues
KR102371420B1 (ko) * 2017-06-27 2022-03-08 (주)아모레퍼시픽 Tnfsf14 단백질을 포함하는 미백용 조성물
AU2019336180A1 (en) * 2018-09-05 2021-04-15 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic virus platform to treat hematological cancer
CN116426483B (zh) * 2021-12-30 2024-02-23 南京紫珑生物科技有限公司 Cd258蛋白在免疫治疗中的应用
CA3258663A1 (en) * 2022-06-08 2023-12-14 Gilead Sciences, Inc. MUTÉINES LIGHT AND THEIR USES
CN116083435A (zh) * 2022-11-04 2023-05-09 吉林大学 以人源light截短型突变蛋白为基础的抗肿瘤的应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5436146A (en) 1989-09-07 1995-07-25 The Trustees Of Princeton University Helper-free stocks of recombinant adeno-associated virus vectors
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5874560A (en) 1994-04-22 1999-02-23 The United States Of America As Represented By The Department Of Health And Human Services Melanoma antigens and their use in diagnostic and therapeutic methods
US6214388B1 (en) 1994-11-09 2001-04-10 The Regents Of The University Of California Immunoliposomes that optimize internalization into target cells
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
DE69718029T2 (de) 1996-10-11 2003-10-16 The Regents Of The University Of California, Oakland Krebs immuntherapie unter verwendung von tumorzellen kombiniert mit lymphozytmischungen
US6048551A (en) 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors
WO2001079496A2 (en) 2000-03-13 2001-10-25 La Jolla Institute For Allergy And Immunology Ligand for herpes simplex virus entry mediator and methods of use
AU2004253465A1 (en) * 2003-06-11 2005-01-13 The University Of Chicago Increased T-cell tumor infiltration by mutant light
US7811983B2 (en) * 2003-06-11 2010-10-12 The University Of Chicago Increased T-cell tumor infiltration and eradication of metastases by mutant light
EP2650018A3 (en) * 2007-05-14 2014-09-03 The University of Chicago Antibody-LIGHT fusion products for cancer therapeutics
CN102753193A (zh) * 2008-10-31 2012-10-24 比奥根艾迪克Ma公司 Light靶向分子及其用途
CA2858876A1 (en) 2011-12-15 2013-06-20 The University Of Chicago Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors

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US10167328B2 (en) 2019-01-01
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US20170137484A1 (en) 2017-05-18
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US20150056219A1 (en) 2015-02-26

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