AU2012299060B2 - Meta-substituted biphenyl peripherally restricted FAAH inhibitors - Google Patents

Meta-substituted biphenyl peripherally restricted FAAH inhibitors Download PDF

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Publication number
AU2012299060B2
AU2012299060B2 AU2012299060A AU2012299060A AU2012299060B2 AU 2012299060 B2 AU2012299060 B2 AU 2012299060B2 AU 2012299060 A AU2012299060 A AU 2012299060A AU 2012299060 A AU2012299060 A AU 2012299060A AU 2012299060 B2 AU2012299060 B2 AU 2012299060B2
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AU
Australia
Prior art keywords
compound
faah
pain
alkyl
hydrogen
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AU2012299060A
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AU2012299060A1 (en
Inventor
Tiziano Bandiera
Marco Mor
Guillermo Moreno-Sanz
Daniele Piomelli
Giorgio Tarzia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Parma
University of Urbino
Italian Institute of Technology
University of California, San Diego
Original Assignee
Degli Studi Di Parma, University of
Degli Studi Di Urbino Carlo Bo, University of
University of Parma
University of Urbino
Italian Institute of Technology
University of California Berkeley
University of California, San Diego
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Application filed by Degli Studi Di Parma, University of, Degli Studi Di Urbino Carlo Bo, University of, University of Parma, University of Urbino, Italian Institute of Technology, University of California Berkeley, University of California, San Diego filed Critical Degli Studi Di Parma, University of
Publication of AU2012299060A1 publication Critical patent/AU2012299060A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2012299060A 2011-08-19 2012-08-17 Meta-substituted biphenyl peripherally restricted FAAH inhibitors Active AU2012299060B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161525636P 2011-08-19 2011-08-19
US61/525,636 2011-08-19
PCT/US2012/051478 WO2013028570A2 (en) 2011-08-19 2012-08-17 Meta-substituted biphenyl peripherally restricted faah inhibitors

Publications (2)

Publication Number Publication Date
AU2012299060A1 AU2012299060A1 (en) 2014-04-03
AU2012299060B2 true AU2012299060B2 (en) 2017-06-01

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AU2012299060A Active AU2012299060B2 (en) 2011-08-19 2012-08-17 Meta-substituted biphenyl peripherally restricted FAAH inhibitors

Country Status (12)

Country Link
US (1) US9745255B2 (enExample)
EP (1) EP2744778B1 (enExample)
JP (1) JP6092870B2 (enExample)
KR (1) KR102079404B1 (enExample)
CN (1) CN104203906B (enExample)
AU (1) AU2012299060B2 (enExample)
BR (1) BR112014003886B1 (enExample)
CA (1) CA2844812C (enExample)
DK (1) DK2744778T3 (enExample)
ES (1) ES2708723T3 (enExample)
MX (1) MX354772B (enExample)
WO (1) WO2013028570A2 (enExample)

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JP6092870B2 (ja) 2011-08-19 2017-03-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア メタ置換ビフェニル末梢に限局されたｆａａｈ阻害剤
WO2014023325A1 (en) * 2012-08-06 2014-02-13 Fondazione Istituto Italiano Di Tecnologia Multitarget faah and cox inhibitors and therapeutical uses thereof
ES2908240T3 (es) * 2014-04-07 2022-04-28 Univ California Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos
WO2017025588A1 (en) * 2015-08-11 2017-02-16 Eyesiu Medicines B.V. Pegylated lipid nanoparticle with bioactive lipophilic compound
CN109414596B (zh) * 2016-05-12 2023-09-29 密歇根大学董事会 Ash1l抑制剂和用其进行治疗的方法
SG10201802129QA (en) 2017-07-05 2019-02-27 Frimline Private Ltd A pharmaceutical composition for neuropathic pain
US10702487B2 (en) 2017-08-19 2020-07-07 Frimline Private Limited Pharmaceutical composition for prevention of diet induced obesity
PH12018000227B1 (en) 2017-09-05 2019-03-11 Frimline Private Ltd A pharmaceutical composition for improving or preventing progression of chronic kidney disease
GB201802326D0 (en) 2018-02-13 2018-03-28 Ucl Business Plc Gene therapy
ES3053087T3 (en) 2018-03-05 2026-01-19 Wylder Nation Found A fatty acid amide hydrolase (faahi) inhibitor for use in inhibiting the cellular accumulation of a sphingolipid in a subject that has lysosomal storage disease or disorder
CA3125980A1 (en) * 2019-01-10 2020-07-16 Travecta Therapeutics Pte. Ltd. Anandamide compounds
US20230313196A1 (en) * 2020-07-23 2023-10-05 John Mansell Compositions and methods for treating pain and anxiety disorders
CN120965462B (zh) * 2025-10-17 2026-02-17 四川奥邦古得药业有限公司 用于生产3,5-二醚戊苯的方法及其在制备3,5-二羟基戊苯中的应用
CN121342719A (zh) * 2025-10-17 2026-01-16 成都奥邦药业有限公司 一种式5所示和2的化合物的制备方法以及大麻二酚的制备方法

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US20090048337A1 (en) * 2002-10-07 2009-02-19 The Regents Of The University Of California Modulation of anxiety through blockade of anandamide hydrolysis
WO2012015704A2 (en) * 2010-07-28 2012-02-02 The Regents Of The University Of California Peripherally restricted faah inhibitors

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Also Published As

Publication number Publication date
WO2013028570A3 (en) 2013-04-18
MX2014001966A (es) 2015-04-08
MX354772B (es) 2018-03-21
US20140288170A1 (en) 2014-09-25
NZ622480A (en) 2016-05-27
HK1198644A1 (en) 2015-05-22
JP2014527532A (ja) 2014-10-16
ES2708723T3 (es) 2019-04-10
WO2013028570A2 (en) 2013-02-28
CN104203906A (zh) 2014-12-10
EP2744778A4 (en) 2015-04-08
AU2012299060A1 (en) 2014-04-03
BR112014003886B1 (pt) 2022-04-19
JP6092870B2 (ja) 2017-03-08
EP2744778A2 (en) 2014-06-25
BR112014003886A8 (pt) 2018-01-23
EP2744778B1 (en) 2019-01-16
CN104203906B (zh) 2018-03-13
CA2844812A1 (en) 2013-02-28
US9745255B2 (en) 2017-08-29
DK2744778T3 (en) 2019-03-04
CA2844812C (en) 2019-10-22
KR102079404B1 (ko) 2020-02-19
KR20150100485A (ko) 2015-09-02
BR112014003886A2 (pt) 2017-03-21

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