MX2014001966A - Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido. - Google Patents

Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido.

Info

Publication number
MX2014001966A
MX2014001966A MX2014001966A MX2014001966A MX2014001966A MX 2014001966 A MX2014001966 A MX 2014001966A MX 2014001966 A MX2014001966 A MX 2014001966A MX 2014001966 A MX2014001966 A MX 2014001966A MX 2014001966 A MX2014001966 A MX 2014001966A
Authority
MX
Mexico
Prior art keywords
faah
methods
present
meta
peripherally restricted
Prior art date
Application number
MX2014001966A
Other languages
English (en)
Other versions
MX354772B (es
Inventor
Daniele Piomelli
Guillermo Moreno-Sanz
Tiziano Bandiera
Marco Mor
Giorgio Tarzia
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of MX2014001966A publication Critical patent/MX2014001966A/es
Publication of MX354772B publication Critical patent/MX354772B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

La presente invención proporciona métodos para realizar y utilizar inhibidores restringidos periféricamente de la hidrolasa de la amida de ácidos grasos (FAAH). La presente invención proporciona compuestos y composiciones que suprimen la actividad de la FAAH y aumenta los niveles de anandamida fuerza del sistema nervioso central (SNC). La presente invención también establece métodos para inhibir la FAAH, así como métodos para tratar afecciones tales como, de modo no taxativo, dolor inflmación, trastornos inmunológicos, dermatitis, mucositis, la hiperreactividad de neuronas sensoriales periféricas, neurodermatitis y vejiga hiperactiva. Por consiguiente, la invención también proporciona compuestos, métodos y composiciones farmacéuticas para tratar afecciones en las que la inhibición selectiva de la FAAH periférica (en oposición a la FAAH del SNC) sería beneficiosa.
MX2014001966A 2011-08-19 2012-08-17 Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido. MX354772B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161525636P 2011-08-19 2011-08-19
PCT/US2012/051478 WO2013028570A2 (en) 2011-08-19 2012-08-17 Meta-substituted biphenyl peripherally restricted faah inhibitors

Publications (2)

Publication Number Publication Date
MX2014001966A true MX2014001966A (es) 2015-04-08
MX354772B MX354772B (es) 2018-03-21

Family

ID=47747054

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001966A MX354772B (es) 2011-08-19 2012-08-17 Inhibidores de la amida de acidos grasos (faah) restringidos perifericamente por bifenil metasustituido.

Country Status (13)

Country Link
US (1) US9745255B2 (es)
EP (1) EP2744778B1 (es)
JP (1) JP6092870B2 (es)
KR (1) KR102079404B1 (es)
CN (1) CN104203906B (es)
AU (1) AU2012299060B2 (es)
BR (1) BR112014003886B1 (es)
CA (1) CA2844812C (es)
DK (1) DK2744778T3 (es)
ES (1) ES2708723T3 (es)
HK (1) HK1198644A1 (es)
MX (1) MX354772B (es)
WO (1) WO2013028570A2 (es)

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KR100485727B1 (ko) * 2004-06-24 2005-04-27 주식회사 바이오리더스 폴리감마글루탐산-비타민 복합체 및 그 용도
EP2744778B1 (en) 2011-08-19 2019-01-16 The Regents of The University of California Meta-substituted biphenyl peripherally restricted faah inhibitors
WO2014023325A1 (en) * 2012-08-06 2014-02-13 Fondazione Istituto Italiano Di Tecnologia Multitarget faah and cox inhibitors and therapeutical uses thereof
EP3129354B1 (en) * 2014-04-07 2022-01-05 The Regents of the University of California Inhibitors of fatty acid amide hydrolase (faah) enzyme with improved oral bioavailability and their use as medicaments
CN108348468A (zh) 2015-08-11 2018-07-31 Eyesiu医疗股份有限公司 具有生物活性亲脂性化合物的聚乙二醇化脂质纳米粒
US10702487B2 (en) 2017-08-19 2020-07-07 Frimline Private Limited Pharmaceutical composition for prevention of diet induced obesity
SG10201807034XA (en) 2017-09-05 2019-04-29 Frimline Private Ltd A pharmaceutical composition for improving or preventing progression of Chronic Kidney Disease
CN113784754A (zh) * 2019-01-10 2021-12-10 特拉维克塔治疗私人有限公司 花生四烯乙醇胺化合物
CA3186853A1 (en) * 2020-07-23 2022-01-27 John Mansell Compositions and methods for treating pain and anxiety disorders

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Also Published As

Publication number Publication date
CA2844812A1 (en) 2013-02-28
BR112014003886A2 (pt) 2017-03-21
BR112014003886A8 (pt) 2018-01-23
ES2708723T3 (es) 2019-04-10
JP6092870B2 (ja) 2017-03-08
BR112014003886B1 (pt) 2022-04-19
HK1198644A1 (en) 2015-05-22
KR20150100485A (ko) 2015-09-02
EP2744778B1 (en) 2019-01-16
AU2012299060A1 (en) 2014-04-03
CN104203906B (zh) 2018-03-13
NZ622480A (en) 2016-05-27
CA2844812C (en) 2019-10-22
AU2012299060B2 (en) 2017-06-01
JP2014527532A (ja) 2014-10-16
WO2013028570A3 (en) 2013-04-18
EP2744778A2 (en) 2014-06-25
CN104203906A (zh) 2014-12-10
DK2744778T3 (en) 2019-03-04
US20140288170A1 (en) 2014-09-25
EP2744778A4 (en) 2015-04-08
MX354772B (es) 2018-03-21
KR102079404B1 (ko) 2020-02-19
WO2013028570A2 (en) 2013-02-28
US9745255B2 (en) 2017-08-29

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