DK2744778T3 - FAAH INHIBITORS PERIPHERALLY LIMITED BY META-SUBSTITUTED BIPHENYL - Google Patents
FAAH INHIBITORS PERIPHERALLY LIMITED BY META-SUBSTITUTED BIPHENYL Download PDFInfo
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- DK2744778T3 DK2744778T3 DK12826376.1T DK12826376T DK2744778T3 DK 2744778 T3 DK2744778 T3 DK 2744778T3 DK 12826376 T DK12826376 T DK 12826376T DK 2744778 T3 DK2744778 T3 DK 2744778T3
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- Prior art keywords
- compound
- pain
- alkyl
- variants
- faah
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- 239000003940 fatty acid amidase inhibitor Substances 0.000 title description 42
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title description 6
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161525636P | 2011-08-19 | 2011-08-19 | |
| PCT/US2012/051478 WO2013028570A2 (en) | 2011-08-19 | 2012-08-17 | Meta-substituted biphenyl peripherally restricted faah inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2744778T3 true DK2744778T3 (en) | 2019-03-04 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12826376.1T DK2744778T3 (en) | 2011-08-19 | 2012-08-17 | FAAH INHIBITORS PERIPHERALLY LIMITED BY META-SUBSTITUTED BIPHENYL |
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| Country | Link |
|---|---|
| US (1) | US9745255B2 (enExample) |
| EP (1) | EP2744778B1 (enExample) |
| JP (1) | JP6092870B2 (enExample) |
| KR (1) | KR102079404B1 (enExample) |
| CN (1) | CN104203906B (enExample) |
| AU (1) | AU2012299060B2 (enExample) |
| BR (1) | BR112014003886B1 (enExample) |
| CA (1) | CA2844812C (enExample) |
| DK (1) | DK2744778T3 (enExample) |
| ES (1) | ES2708723T3 (enExample) |
| MX (1) | MX354772B (enExample) |
| WO (1) | WO2013028570A2 (enExample) |
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| KR100485727B1 (ko) * | 2004-06-24 | 2005-04-27 | 주식회사 바이오리더스 | 폴리감마글루탐산-비타민 복합체 및 그 용도 |
| CA2844812C (en) | 2011-08-19 | 2019-10-22 | Daniele Piomelli | Meta-substituted biphenyl peripherally restricted faah inhibitors |
| WO2014023325A1 (en) * | 2012-08-06 | 2014-02-13 | Fondazione Istituto Italiano Di Tecnologia | Multitarget faah and cox inhibitors and therapeutical uses thereof |
| ES2908240T3 (es) | 2014-04-07 | 2022-04-28 | Univ California | Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos |
| EP3334416A1 (en) | 2015-08-11 | 2018-06-20 | Eyesiu Medicines B.V. | Pegylated lipid nanoparticle with bioactive lipophilic compound |
| EP3454945B1 (en) * | 2016-05-12 | 2022-01-19 | The Regents Of The University Of Michigan | Ash1l inhibitors and methods of treatment therewith |
| MY172113A (en) | 2017-07-05 | 2019-11-14 | Frimline Private Ltd | A pharmaceutical composition for neuropathic pain |
| US10702487B2 (en) | 2017-08-19 | 2020-07-07 | Frimline Private Limited | Pharmaceutical composition for prevention of diet induced obesity |
| PH12018000227B1 (en) | 2017-09-05 | 2019-03-11 | Frimline Private Ltd | A pharmaceutical composition for improving or preventing progression of chronic kidney disease |
| GB201802326D0 (en) | 2018-02-13 | 2018-03-28 | Ucl Business Plc | Gene therapy |
| WO2019173394A1 (en) | 2018-03-05 | 2019-09-12 | Wylder Nation Foundation | Compositions and methods for activating signaling through the cb1 cannabinoid receptor for treating and preventing diseases and disorders characterized by abnormal cellular accumulation of sphingolipids such as sphingomyelin |
| CN113784754A (zh) * | 2019-01-10 | 2021-12-10 | 特拉维克塔治疗私人有限公司 | 花生四烯乙醇胺化合物 |
| US20230313196A1 (en) * | 2020-07-23 | 2023-10-05 | John Mansell | Compositions and methods for treating pain and anxiety disorders |
| CN120965462A (zh) * | 2025-10-17 | 2025-11-18 | 四川奥邦古得药业有限公司 | 用于生产3,5-二醚戊苯的方法及其在制备3,5-二羟基戊苯中的应用 |
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| US4325889A (en) | 1978-08-04 | 1982-04-20 | Bayer Aktiengesellschaft | Process for the preparation of 1-amino-8-naphthol-3,6-disulphonic acid (H-acid) |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4511503A (en) | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| EP0604289B1 (fr) | 1992-12-17 | 1997-09-24 | Valeo Systemes D'essuyage | Procédé et dispositif d'alimentation d'un moteur électrique d'entrainement d'un bras d'essuie-glace de véhicule automobile |
| US5576220A (en) | 1993-02-19 | 1996-11-19 | Arris Pharmaceutical Corporation | Thin film HPMP matrix systems and methods for constructing and displaying ligands |
| US6271015B1 (en) | 1995-06-12 | 2001-08-07 | The Scripps Research Institute | Fatty-acid amide hydrolase |
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| WO1998024443A1 (en) | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating bipolar disorders |
| GB9701453D0 (en) | 1997-01-24 | 1997-03-12 | Leo Pharm Prod Ltd | Aminobenzophenones |
| FR2758723B1 (fr) | 1997-01-28 | 1999-04-23 | Sanofi Sa | Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments |
| TW492882B (en) | 1997-11-28 | 2002-07-01 | Caleb Pharmaceuticals Inc | Cholinergic antagonist plaster composition |
| RU2198873C2 (ru) | 1998-02-26 | 2003-02-20 | Акцо Нобель Н.В. | Производные азетидина и пирролидина |
| DE69942317D1 (de) | 1998-05-29 | 2010-06-10 | Neurosciences Res Found | Schmerzlinderung mit anandamide |
| US7897598B2 (en) | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
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| US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
| AU2003237882B2 (en) | 2002-05-16 | 2010-04-08 | Sunovion Pharmaceuticals Inc. | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof |
| FR2842808B1 (fr) | 2002-07-25 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux derives d'arylimidazoles, leur preparation et leurs applications therapeutiques |
| US7176201B2 (en) * | 2002-10-07 | 2007-02-13 | The Regents Of The University Of California | Modulation of anxiety through blockade of anandamide hydrolysis |
| FR2850377B1 (fr) | 2003-01-23 | 2009-02-20 | Sanofi Synthelabo | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
| FR2866888B1 (fr) | 2004-02-26 | 2006-05-05 | Sanofi Synthelabo | Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique |
| US20070155707A1 (en) | 2005-12-29 | 2007-07-05 | Kadmus Pharmaceuticals, Inc. | Ionizable inhibitors of fatty acid amide hydrolase |
| US9316633B2 (en) | 2006-11-16 | 2016-04-19 | The Regents Of The University Of California | Methods for identifying inhibitors of solute transporters |
| WO2008063714A1 (en) * | 2006-11-20 | 2008-05-29 | N.V. Organon | Metabolically-stabilized inhibitors of fatty acid amide hydrolase |
| TW200948805A (en) | 2008-03-07 | 2009-12-01 | Sigma Tau Ind Farmaceuti | Enol carbamate derivatives as modulators of fatty acid amide hydrolase |
| JP5819305B2 (ja) | 2009-10-13 | 2015-11-24 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 造血成長因子模倣小分子化合物およびそれらの使用 |
| RU2583435C2 (ru) | 2010-07-28 | 2016-05-10 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Ингибиторы faah периферически-ограниченного действия |
| WO2012167133A2 (en) | 2011-06-01 | 2012-12-06 | The Regents Of The University Of California | Inhibitors of anandamide transport and their therapeutic uses |
| CA2844812C (en) | 2011-08-19 | 2019-10-22 | Daniele Piomelli | Meta-substituted biphenyl peripherally restricted faah inhibitors |
| ES2908240T3 (es) | 2014-04-07 | 2022-04-28 | Univ California | Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos |
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2012
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- 2012-08-17 AU AU2012299060A patent/AU2012299060B2/en active Active
- 2012-08-17 MX MX2014001966A patent/MX354772B/es active IP Right Grant
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20150100485A (ko) | 2015-09-02 |
| MX354772B (es) | 2018-03-21 |
| MX2014001966A (es) | 2015-04-08 |
| CA2844812C (en) | 2019-10-22 |
| US9745255B2 (en) | 2017-08-29 |
| HK1198644A1 (en) | 2015-05-22 |
| BR112014003886A8 (pt) | 2018-01-23 |
| WO2013028570A2 (en) | 2013-02-28 |
| NZ622480A (en) | 2016-05-27 |
| CA2844812A1 (en) | 2013-02-28 |
| US20140288170A1 (en) | 2014-09-25 |
| JP2014527532A (ja) | 2014-10-16 |
| JP6092870B2 (ja) | 2017-03-08 |
| ES2708723T3 (es) | 2019-04-10 |
| EP2744778A2 (en) | 2014-06-25 |
| CN104203906A (zh) | 2014-12-10 |
| WO2013028570A3 (en) | 2013-04-18 |
| AU2012299060B2 (en) | 2017-06-01 |
| KR102079404B1 (ko) | 2020-02-19 |
| CN104203906B (zh) | 2018-03-13 |
| AU2012299060A1 (en) | 2014-04-03 |
| EP2744778A4 (en) | 2015-04-08 |
| EP2744778B1 (en) | 2019-01-16 |
| BR112014003886B1 (pt) | 2022-04-19 |
| BR112014003886A2 (pt) | 2017-03-21 |
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