AU2012250807A1 - Induction of IL-12 using immunotherapy - Google Patents

Induction of IL-12 using immunotherapy Download PDF

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Publication number
AU2012250807A1
AU2012250807A1 AU2012250807A AU2012250807A AU2012250807A1 AU 2012250807 A1 AU2012250807 A1 AU 2012250807A1 AU 2012250807 A AU2012250807 A AU 2012250807A AU 2012250807 A AU2012250807 A AU 2012250807A AU 2012250807 A1 AU2012250807 A1 AU 2012250807A1
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AU
Australia
Prior art keywords
cells
composition
patient
activated
plasma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2012250807A
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English (en)
Inventor
Michael Har-Noy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunovative Therapies Ltd
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Immunovative Therapies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunovative Therapies Ltd filed Critical Immunovative Therapies Ltd
Publication of AU2012250807A1 publication Critical patent/AU2012250807A1/en
Priority to AU2017204058A priority Critical patent/AU2017204058A1/en
Priority to AU2019204699A priority patent/AU2019204699A1/en
Abandoned legal-status Critical Current

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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012250807A 2011-05-03 2012-05-02 Induction of IL-12 using immunotherapy Abandoned AU2012250807A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017204058A AU2017204058A1 (en) 2011-05-03 2017-06-15 Induction of il-12 using immunotherapy
AU2019204699A AU2019204699A1 (en) 2011-05-03 2019-07-01 Induction of il-12 using immunotherapy

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161482009P 2011-05-03 2011-05-03
US61/482,009 2011-05-03
US201161528484P 2011-08-29 2011-08-29
US61/528,484 2011-08-29
US201161564551P 2011-11-29 2011-11-29
US61/564,551 2011-11-29
US201261582881P 2012-01-04 2012-01-04
US61/582,881 2012-01-04
PCT/US2012/036123 WO2012151279A2 (en) 2011-05-03 2012-05-02 Induction of il-12 using immunotherapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017204058A Division AU2017204058A1 (en) 2011-05-03 2017-06-15 Induction of il-12 using immunotherapy

Publications (1)

Publication Number Publication Date
AU2012250807A1 true AU2012250807A1 (en) 2013-12-12

Family

ID=47108207

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2012250807A Abandoned AU2012250807A1 (en) 2011-05-03 2012-05-02 Induction of IL-12 using immunotherapy
AU2017204058A Abandoned AU2017204058A1 (en) 2011-05-03 2017-06-15 Induction of il-12 using immunotherapy
AU2019204699A Abandoned AU2019204699A1 (en) 2011-05-03 2019-07-01 Induction of il-12 using immunotherapy

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2017204058A Abandoned AU2017204058A1 (en) 2011-05-03 2017-06-15 Induction of il-12 using immunotherapy
AU2019204699A Abandoned AU2019204699A1 (en) 2011-05-03 2019-07-01 Induction of il-12 using immunotherapy

Country Status (12)

Country Link
US (4) US9233156B2 (enExample)
EP (1) EP2704732B1 (enExample)
JP (2) JP6393186B2 (enExample)
KR (1) KR102121492B1 (enExample)
CN (2) CN109876138A (enExample)
AU (3) AU2012250807A1 (enExample)
BR (1) BR112013028285A2 (enExample)
CA (1) CA2838046C (enExample)
IL (1) IL229177B (enExample)
PH (1) PH12013502252B1 (enExample)
SG (2) SG10201901391RA (enExample)
WO (1) WO2012151279A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013028285A2 (pt) * 2011-05-03 2017-01-10 Immunovative Therapies Ltd indução de il-12 usando imunoterapia
MX390311B (es) 2013-12-05 2025-03-20 Rfemb Holdings Llc Presentacion de antigeno de cancer mejorado a celulas que presentan por la descomposicion electrica de membrana por radiofrecuencia (rf-rmb) como un mecanismo adyuvante para la inmunoterapia.
JP6202339B2 (ja) * 2013-12-19 2017-09-27 国立研究開発法人国立精神・神経医療研究センター ＧＭ−ＣＳＦ産生Ｔ細胞制御剤、及びＴｈ１／Ｔｈ２免疫バランス調節剤
CA2975123A1 (en) 2015-01-30 2016-08-04 Rfemb Holdings, Llc Radio frequency electrical membrane breakdown for the treatment of high risk and recurrent prostate cancer, unresectable pancreatic cancer, tumors of the breast, melanoma or other skin malignancies, sarcoma, soft tissue tumors, ductal carcinoma, neoplasia, and intra and extra luminal abnormal tissue
TW202428236A (zh) * 2016-01-15 2024-07-16 美商Ｒｆｅｍｂ控股有限公司 癌症之免疫治療
JP2020528077A (ja) * 2017-07-14 2020-09-17 ミンジェン シュー， Ｍ１優位の免疫応答を誘導するための方法および薬学的組成物

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2439003A1 (fr) 1978-10-20 1980-05-16 Anvar Nouvelles pieces d'osteosynthese, leur preparation et leur application
US5766920A (en) 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
AU7873187A (en) 1986-08-08 1988-02-24 University Of Minnesota Method of culturing leukocytes
ZA888978B (en) 1987-12-04 1990-07-25 Du Pont Immobilized interleukin 2 and interleukin 2 containing a carboxylterminal extension
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5126132A (en) 1989-08-21 1992-06-30 The United States Of America As Represented By The Department Of Health And Human Services Tumor infiltrating lymphocytes as a treatment modality for human cancer
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
JPH0455577A (ja) 1990-06-22 1992-02-24 Mitsubishi Electric Corp 構造物の制振装置
WO1994012196A1 (en) 1992-11-25 1994-06-09 Tanox Biosystems, Inc. Conjugates and constructs including anti-cd28 and anti-cd3 binding molecules
AU7478394A (en) 1993-08-06 1995-02-28 Cytel Corporation Methods for (ex vivo) therapy using peptide-loaded antigen presenting cells for the activation of ctl
IL107483A0 (en) 1993-11-03 1994-02-27 Yeda Res & Dev Bone marrow transplantation
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
ES2201177T3 (es) 1995-03-08 2004-03-16 The Scripps Research Institute Sistema de presentacion de antigenos y activacion de celulas-t.
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
JPH09255577A (ja) * 1996-03-27 1997-09-30 Dainippon Ink & Chem Inc インターリュウキン−１２誘導剤
CA2254975C (en) 1996-05-23 2008-12-16 The Scripps Research Institute Mhc class ii antigen-presenting systems and methods for activating cd4+ t cells
CA2274004A1 (en) 1996-12-03 1998-06-11 Osteobiologics, Inc. Biodegradable polymeric film
WO1998033891A1 (en) 1997-01-31 1998-08-06 Hemosol Inc. Method for the production of selected lymphocytes
DE69840171D1 (de) 1997-05-30 2008-12-11 Osteobiologics Inc Faserverstärkte,poröse,biologisch abbaubare implantatvorrichtung
JP2001522806A (ja) 1997-11-10 2001-11-20 アーチ・デヴェロップメント・コーポレイション エクス・ビボ活性化ｔ細胞を用いる腫瘍および腫瘍細胞の処理方法
JP2001054563A (ja) 1999-07-12 2001-02-27 Isotis Bv 縫合糸
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US20030119185A1 (en) 2000-02-24 2003-06-26 Xcyte Therapies, Inc. Activation and expansion of cells
DK1257632T3 (da) 2000-02-24 2008-01-28 Xcyte Therapies Inc Samtidig stimulering og opkoncentrering af celler
WO2001062092A1 (en) 2000-02-25 2001-08-30 Thomas Jefferson University Formulations and methods for using the same to elicit an immune response
AU2001292564A1 (en) 2000-08-31 2002-03-13 Emory University A method of transplantation using chemotherapy-treated allogeneic cells that enhance immune responses without graft versus host disease
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
AU2002342299A1 (en) 2001-10-31 2003-05-12 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Generation of use of tc1 and tc2 cells
US7105580B2 (en) 2001-12-06 2006-09-12 University Of Washington Porous structures useful for growing living tissue, and methods of manufacture
US20030175272A1 (en) 2002-03-07 2003-09-18 Medcell Biologics, Inc. Re-activated T-cells for adoptive immunotherapy
DE10230223A1 (de) 2002-07-04 2004-01-22 Tegenero Ag Mikropartikel mit CD28-spezifischen monoklonalen Antikörpern
CN1399054A (zh) * 2002-09-03 2003-02-26 宋有财 旋转式的泊车装置
US20110142887A1 (en) 2009-12-15 2011-06-16 Immunovative Therapies Ltd. Methods and compositions for liquidation of tumors
US7402431B2 (en) 2004-03-01 2008-07-22 Immunovative Therapies, Ltd. T-cell therapy formulation
US7435592B2 (en) * 2003-05-13 2008-10-14 Immunovative Therapies, Ltd. Compositions for allogeneic cell therapy
US7371228B2 (en) 2003-09-19 2008-05-13 Medtronic Vascular, Inc. Delivery of therapeutics to treat aneurysms
US7592431B2 (en) 2004-02-26 2009-09-22 Immunovative Therapies, Ltd. Biodegradable T-cell Activation device
US7678572B2 (en) 2004-02-26 2010-03-16 Immunovative Therapies, Ltd. Methods for preparing T-cells for cell therapy
US7446099B2 (en) 2004-02-27 2008-11-04 Nitto Denko Corporation Compositions and methods for biodegradable polymer-peptide mediated transfection
ES2635868T3 (es) * 2004-03-01 2017-10-05 Immunovative Therapies, Ltd. Método y composición de formulación de terapia celular
WO2005089127A2 (en) 2004-03-05 2005-09-29 The Trustees Of Columbia University In The City Of New York Polymer-ceramic-hydrogel composite scaffold for osteochondral repair
US8865224B2 (en) * 2004-10-14 2014-10-21 Immunovative Therapies Ltd. Allogeneic cellular immunotherapy for opportunistic infection
DK2003978T3 (da) * 2006-04-13 2014-07-07 Immunovative Therapies Ltd Allogen celleterapi til behandling af opportunistisk infektion
US20080112963A1 (en) * 2006-11-13 2008-05-15 Immunovative Therapies, Ltd. Ablative immunotherapy
US7972594B2 (en) * 2006-11-13 2011-07-05 Immunovative Therapies Ltd. Ablative immunotherapy
EP2025746A1 (en) * 2007-08-16 2009-02-18 Cell Med Research GMBH Dendritic cells
US20120128656A1 (en) * 2008-05-02 2012-05-24 Immunovative Therapies, Ltd. Vaccine compositions and methods
BR112013028285A2 (pt) 2011-05-03 2017-01-10 Immunovative Therapies Ltd indução de il-12 usando imunoterapia

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