SG10201901391RA - Induction of il-12 using immunotherapy - Google Patents

Induction of il-12 using immunotherapy

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Publication number
SG10201901391RA
SG10201901391RA SG10201901391RA SG10201901391RA SG10201901391RA SG 10201901391R A SG10201901391R A SG 10201901391RA SG 10201901391R A SG10201901391R A SG 10201901391RA SG 10201901391R A SG10201901391R A SG 10201901391RA SG 10201901391R A SG10201901391R A SG 10201901391RA
Authority
SG
Singapore
Prior art keywords
patient
induction
immunotherapy
composition
skews
Prior art date
Application number
SG10201901391RA
Inventor
Michael Har-Noy
Original Assignee
Immunovative Therapies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunovative Therapies Ltd filed Critical Immunovative Therapies Ltd
Publication of SG10201901391RA publication Critical patent/SG10201901391RA/en

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    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0637Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • AHUMAN NECESSITIES
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    • A61K2039/55533IL-2
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Abstract

INDUCTION OF IL-12 USING IMMUNOTHERAPY The present invention relates to compositions and methods that promote the induction of IL-12 in a patient. The composition includes activated allogeneic cells that are administered to a patient with a disease such as cancer. Administration of the composition skews the patient's immune response to a Thl environment and produces detectable levels of IL-12 in the patient's plasma, without any IL-12 related toxicity. (FIGURE 1)
SG10201901391RA 2011-05-03 2012-05-02 Induction of il-12 using immunotherapy SG10201901391RA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161482009P 2011-05-03 2011-05-03
US201161528484P 2011-08-29 2011-08-29
US201161564551P 2011-11-29 2011-11-29
US201261582881P 2012-01-04 2012-01-04

Publications (1)

Publication Number Publication Date
SG10201901391RA true SG10201901391RA (en) 2019-03-28

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SG10201901391RA SG10201901391RA (en) 2011-05-03 2012-05-02 Induction of il-12 using immunotherapy
SG2013081302A SG194753A1 (en) 2011-05-03 2012-05-02 Induction of il-12 using immunotherapy

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SG2013081302A SG194753A1 (en) 2011-05-03 2012-05-02 Induction of il-12 using immunotherapy

Country Status (11)

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US (3) US9233156B2 (en)
EP (1) EP2704732B1 (en)
JP (2) JP6393186B2 (en)
KR (1) KR102121492B1 (en)
CN (2) CN103687602A (en)
AU (3) AU2012250807A1 (en)
BR (1) BR112013028285A2 (en)
CA (1) CA2838046C (en)
IL (1) IL229177B (en)
SG (2) SG10201901391RA (en)
WO (1) WO2012151279A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201901391RA (en) 2011-05-03 2019-03-28 Immunovative Therapies Ltd Induction of il-12 using immunotherapy
CN111167008A (en) 2013-12-05 2020-05-19 免疫系统公司 Cancer immunotherapy with radiofrequency electrical membrane breakdown (RF-EMB)
JP6202339B2 (en) * 2013-12-19 2017-09-27 国立研究開発法人国立精神・神経医療研究センター GM-CSF producing T cell regulator and Th1 / Th2 immune balance regulator
WO2016123608A2 (en) 2015-01-30 2016-08-04 Rfemb Holdings, Llc Radio-frequency electrical membrane breakdown for the treatment of high risk and recurrent prostate cancer, unresectable pancreatic cancer, tumors of the breast, melanoma or other skin malignancies, sarcoma, soft tissue tumors, ductal carcinoma, neoplasia, and intra and extra luminal abnormal tissue
CN109069624A (en) 2016-01-15 2018-12-21 瑞美控股有限责任公司 The immunization therapy of cancer
JP2020528077A (en) * 2017-07-14 2020-09-17 ミンジェン シュー, Methods and Pharmaceutical Compositions for Inducing M1-Predominant Immune Responses

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2439003A1 (en) 1978-10-20 1980-05-16 Anvar NEW OSTEOSYNTHESIS PARTS, THEIR PREPARATION AND THEIR APPLICATION
US5766920A (en) 1982-08-11 1998-06-16 Cellcor, Inc. Ex vivo activation of immune cells
WO1988000970A2 (en) 1986-08-08 1988-02-11 Regents Of The University Of Minnesota Method of culturing leukocytes
PT89121A (en) 1987-12-04 1989-12-29 Du Pont PROCESS FOR THE PREPARATION OF INTERLEUQUIN-2 FIXED AND INTERLEUKIN-2 CONTAINING AN EXTENSION IN THE TERMINAL-CARBOXYL WITH ACTIVITY OF INTERLEUQUIN-2 NATURAL
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5126132A (en) 1989-08-21 1992-06-30 The United States Of America As Represented By The Department Of Health And Human Services Tumor infiltrating lymphocytes as a treatment modality for human cancer
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
JPH0455577A (en) 1990-06-22 1992-02-24 Mitsubishi Electric Corp Vibration controlling device of construction
AU5729294A (en) 1992-11-25 1994-06-22 Tanox Biosystems, Inc. Conjugates and constructs including anti-cd28 and anti-cd3 binding molecules
EP0726941B1 (en) 1993-08-06 2002-04-03 Epimmune Inc. Methods for (ex vivo) therapy using peptide-loaded antigen presenting cells for the activation of ctl
IL107483A0 (en) 1993-11-03 1994-02-27 Yeda Res & Dev Bone marrow transplantation
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
JP3926842B2 (en) 1995-03-08 2007-06-06 ザ・スクリプス・リサーチ・インステイチユート ANTIGEN PRESENTATION SYSTEM AND T-CELL ACTIVATION METHOD
DE19545257A1 (en) 1995-11-24 1997-06-19 Schering Ag Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
JPH09255577A (en) * 1996-03-27 1997-09-30 Dainippon Ink & Chem Inc Agent for inducing interleukin-12
WO1997046256A1 (en) 1996-05-23 1997-12-11 The Scripps Research Institute Mhc class ii antigen-presenting systems and methods for activating cd4+ t cells
AU5596898A (en) 1996-12-03 1998-06-29 Osteobiologics, Inc. Biodegradable polymeric film
CA2278847A1 (en) 1997-01-31 1998-08-06 Hemosol Inc. Method for the production of selected lymphocytes
JP4132089B2 (en) 1997-05-30 2008-08-13 オステオバイオロジックス,インコーポレイテッド Fiber reinforced porous biodegradable implantation device
JP2001522806A (en) 1997-11-10 2001-11-20 アーチ・デヴェロップメント・コーポレイション Methods for treating tumors and tumor cells using ex vivo activated T cells
AU4518400A (en) 1999-07-12 2001-01-18 Isotis B.V. Sutures
US20030119185A1 (en) 2000-02-24 2003-06-26 Xcyte Therapies, Inc. Activation and expansion of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
KR20030032922A (en) 2000-02-24 2003-04-26 싸이트 테라피스 인코포레이티드 Simultaneous stimulation and concentration of cells
WO2001062092A1 (en) 2000-02-25 2001-08-30 Thomas Jefferson University Formulations and methods for using the same to elicit an immune response
WO2002017935A2 (en) 2000-08-31 2002-03-07 Emory University A method of transplantation using chemotherapy-treated allogeneic cells that enhance immune responses without graft versus host disease
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
AU2002342299A1 (en) 2001-10-31 2003-05-12 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Generation of use of tc1 and tc2 cells
US7105580B2 (en) 2001-12-06 2006-09-12 University Of Washington Porous structures useful for growing living tissue, and methods of manufacture
US20030175272A1 (en) 2002-03-07 2003-09-18 Medcell Biologics, Inc. Re-activated T-cells for adoptive immunotherapy
DE10230223A1 (en) 2002-07-04 2004-01-22 Tegenero Ag Microparticles with CD28-specific monoclonal antibodies
CN1399054A (en) * 2002-09-03 2003-02-26 宋有财 Rotary car parking plant
US7435592B2 (en) * 2003-05-13 2008-10-14 Immunovative Therapies, Ltd. Compositions for allogeneic cell therapy
US20110142887A1 (en) 2009-12-15 2011-06-16 Immunovative Therapies Ltd. Methods and compositions for liquidation of tumors
US7402431B2 (en) 2004-03-01 2008-07-22 Immunovative Therapies, Ltd. T-cell therapy formulation
US7371228B2 (en) 2003-09-19 2008-05-13 Medtronic Vascular, Inc. Delivery of therapeutics to treat aneurysms
WO2005081982A2 (en) 2004-02-26 2005-09-09 Immunovative Therapies, Ltd. Methods for preparing t-cells for cell therapy
US7592431B2 (en) 2004-02-26 2009-09-22 Immunovative Therapies, Ltd. Biodegradable T-cell Activation device
US7446099B2 (en) 2004-02-27 2008-11-04 Nitto Denko Corporation Compositions and methods for biodegradable polymer-peptide mediated transfection
HUE035726T2 (en) * 2004-03-01 2018-05-28 Immunovative Therapies Ltd Cell therapy formulation method and composition
WO2005089127A2 (en) 2004-03-05 2005-09-29 The Trustees Of Columbia University In The City Of New York Polymer-ceramic-hydrogel composite scaffold for osteochondral repair
US8865224B2 (en) 2004-10-14 2014-10-21 Immunovative Therapies Ltd. Allogeneic cellular immunotherapy for opportunistic infection
PT2003978E (en) * 2006-04-13 2014-07-25 Immunovative Therapies Ltd Allogeneic cell therapy for treatment of opportunistic infection
US20080112963A1 (en) * 2006-11-13 2008-05-15 Immunovative Therapies, Ltd. Ablative immunotherapy
US7972594B2 (en) * 2006-11-13 2011-07-05 Immunovative Therapies Ltd. Ablative immunotherapy
EP2025746A1 (en) * 2007-08-16 2009-02-18 Cell Med Research GMBH Dendritic cells
US20120128656A1 (en) 2008-05-02 2012-05-24 Immunovative Therapies, Ltd. Vaccine compositions and methods
SG10201901391RA (en) * 2011-05-03 2019-03-28 Immunovative Therapies Ltd Induction of il-12 using immunotherapy

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