AU2012225548B2 - Methods and compositions for treating depression using cyclobenzaprine - Google Patents

Methods and compositions for treating depression using cyclobenzaprine Download PDF

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Publication number
AU2012225548B2
AU2012225548B2 AU2012225548A AU2012225548A AU2012225548B2 AU 2012225548 B2 AU2012225548 B2 AU 2012225548B2 AU 2012225548 A AU2012225548 A AU 2012225548A AU 2012225548 A AU2012225548 A AU 2012225548A AU 2012225548 B2 AU2012225548 B2 AU 2012225548B2
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Prior art keywords
cyclobenzaprine
day
dose
depression
administered
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AU2012225548A1 (en
Inventor
Seth Lederman
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Tonix Pharma Ltd Ireland
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Tonix Pharma Holdings Ltd
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Priority to AU2016222412A priority Critical patent/AU2016222412B2/en
Priority to AU2018204633A priority patent/AU2018204633C1/en
Assigned to TONIX PHARMA HOLDINGS LIMITED reassignment TONIX PHARMA HOLDINGS LIMITED Request for Assignment Assignors: Tonix Pharmaceuticals, Inc.
Priority to AU2020203874A priority patent/AU2020203874B2/en
Assigned to TONIX PHARMA LIMITED reassignment TONIX PHARMA LIMITED Request for Assignment Assignors: TONIX PHARMA HOLDINGS LIMITED
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2012225548A 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine Active AU2012225548B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2016222412A AU2016222412B2 (en) 2011-03-07 2016-08-31 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2018204633A AU2018204633C1 (en) 2011-03-07 2018-06-26 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2020203874A AU2020203874B2 (en) 2011-03-07 2020-06-11 Methods and compositions for treating depression using cyclobenzaprine

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449838P 2011-03-07 2011-03-07
US61/449,838 2011-03-07
PCT/US2012/027926 WO2012122193A1 (en) 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine

Related Child Applications (1)

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AU2016222412A Division AU2016222412B2 (en) 2011-03-07 2016-08-31 Methods and Compositions for Treating Depression Using Cyclobenzaprine

Publications (2)

Publication Number Publication Date
AU2012225548A1 AU2012225548A1 (en) 2013-09-19
AU2012225548B2 true AU2012225548B2 (en) 2016-06-02

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ID=46796107

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2012225548A Active AU2012225548B2 (en) 2011-03-07 2012-03-06 Methods and compositions for treating depression using cyclobenzaprine
AU2016222412A Active AU2016222412B2 (en) 2011-03-07 2016-08-31 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2018204633A Active AU2018204633C1 (en) 2011-03-07 2018-06-26 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2020203874A Active AU2020203874B2 (en) 2011-03-07 2020-06-11 Methods and compositions for treating depression using cyclobenzaprine

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2016222412A Active AU2016222412B2 (en) 2011-03-07 2016-08-31 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2018204633A Active AU2018204633C1 (en) 2011-03-07 2018-06-26 Methods and Compositions for Treating Depression Using Cyclobenzaprine
AU2020203874A Active AU2020203874B2 (en) 2011-03-07 2020-06-11 Methods and compositions for treating depression using cyclobenzaprine

Country Status (18)

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US (1) US11998516B2 (enExample)
EP (2) EP2683245B2 (enExample)
JP (2) JP2014507475A (enExample)
AU (4) AU2012225548B2 (enExample)
CA (1) CA2829200C (enExample)
CY (1) CY1122998T1 (enExample)
DK (1) DK2683245T4 (enExample)
ES (1) ES2773834T5 (enExample)
FI (1) FI2683245T4 (enExample)
HR (1) HRP20200142T4 (enExample)
HU (1) HUE048596T2 (enExample)
LT (1) LT2683245T (enExample)
PL (1) PL2683245T5 (enExample)
PT (1) PT2683245T (enExample)
RS (1) RS60240B2 (enExample)
SI (1) SI2683245T2 (enExample)
SM (1) SMT202000083T1 (enExample)
WO (1) WO2012122193A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2501234T (lt) * 2009-11-20 2017-12-11 Tonix Pharma Holdings Limited Būdai ir kompozicijos, skirti simptomų, susijusių su potrauminiu streso sutrikimu, gydymui naudojant ciklobenzapriną
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
PL3650081T3 (pl) 2013-03-15 2024-06-24 Tonix Pharma Holdings Limited Eutektyczne preparaty chlorowodorku cyklobenzapryny i mannitolu
WO2015150948A1 (en) * 2014-03-29 2015-10-08 Wockhardt Limited Modified release solid oral pharmaceutical compositions of cyclobenzaprine or a salt thereof
MY186047A (en) 2014-09-18 2021-06-17 Tonix Pharma Holdings Ltd Eutectic formulations of cyclobenzaprine hydrochloride
CN106890129A (zh) * 2015-12-18 2017-06-27 健乔信元医药生技股份有限公司 环苄普林之延释剂型
CN118267382A (zh) * 2017-12-11 2024-07-02 通尼克斯制药控股有限公司 用于痴呆和神经变性病况中的激越、精神病和认知衰退的环苯扎林治疗

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US20050096327A1 (en) * 2003-11-03 2005-05-05 Caprathe Bradley W. Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders

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Also Published As

Publication number Publication date
PL2683245T3 (pl) 2020-10-05
DK2683245T3 (da) 2020-02-24
EP3682885A1 (en) 2020-07-22
SI2683245T2 (sl) 2023-04-28
FI2683245T4 (fi) 2023-01-13
CA2829200C (en) 2022-05-03
HUE048596T2 (hu) 2020-08-28
AU2016222412A1 (en) 2016-09-22
AU2018204633A1 (en) 2018-07-12
EP2683245B2 (en) 2022-12-07
CY1122998T1 (el) 2021-10-29
AU2018204633B2 (en) 2020-03-12
NZ614725A (en) 2016-07-29
NZ714294A (en) 2017-06-30
EP2683245A4 (en) 2014-08-27
AU2018204633C1 (en) 2020-09-10
JP2016053095A (ja) 2016-04-14
PL2683245T5 (pl) 2023-03-20
AU2016222412B2 (en) 2018-03-29
JP2014507475A (ja) 2014-03-27
HRP20200142T1 (hr) 2020-06-26
ES2773834T5 (es) 2023-03-16
WO2012122193A1 (en) 2012-09-13
EP2683245A1 (en) 2014-01-15
AU2020203874A1 (en) 2020-07-02
RS60240B1 (sr) 2020-06-30
ES2773834T3 (es) 2020-07-15
RS60240B2 (sr) 2023-05-31
AU2020203874B2 (en) 2021-09-09
EP2683245B1 (en) 2019-12-25
US20120232159A1 (en) 2012-09-13
PT2683245T (pt) 2020-02-21
DK2683245T4 (da) 2023-01-09
US11998516B2 (en) 2024-06-04
AU2012225548A1 (en) 2013-09-19
LT2683245T (lt) 2020-03-25
CA2829200A1 (en) 2012-09-13
HRP20200142T4 (hr) 2023-02-17
SI2683245T1 (sl) 2020-07-31
SMT202000083T1 (it) 2020-05-08

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