AU2012225337B2 - Active agent prodrugs with heterocyclic linkers - Google Patents
Active agent prodrugs with heterocyclic linkers Download PDFInfo
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- AU2012225337B2 AU2012225337B2 AU2012225337A AU2012225337A AU2012225337B2 AU 2012225337 B2 AU2012225337 B2 AU 2012225337B2 AU 2012225337 A AU2012225337 A AU 2012225337A AU 2012225337 A AU2012225337 A AU 2012225337A AU 2012225337 B2 AU2012225337 B2 AU 2012225337B2
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- Prior art keywords
- substituted
- alkyl
- active agent
- aryl
- ring
- Prior art date
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- WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 description 1
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Classifications
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Landscapes
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| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| CN103384472B (zh) | 2011-01-11 | 2016-01-20 | 特色疗法股份有限公司 | 包含酶可裂解的羟考酮药物前体的组合物 |
| WO2012122420A2 (en) | 2011-03-09 | 2012-09-13 | Pharmacofore, Inc. | Opioid prodrugs with heterocyclic linkers |
| BR112013022946A2 (pt) | 2011-03-09 | 2017-07-18 | Signature Therapeutics Inc | pró-fármacos de agentes ativos com ligantes heterocíclocos |
| JP5977355B2 (ja) | 2011-09-29 | 2016-08-24 | エコール ノルマル シュペリウール ドゥ リヨン | ペプチダーゼの蛍光発生基質 |
| EP3077008B1 (en) | 2013-12-06 | 2023-10-04 | Jie Han | Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs |
| US11634384B2 (en) | 2014-11-25 | 2023-04-25 | Concentric Analgesics, Inc. | Prodrugs of phenolic TRPV1 agonists |
| US20170056352A1 (en) | 2015-08-25 | 2017-03-02 | Rgenix, Inc. | PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF |
| US10335406B2 (en) | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
| AU2016332071B2 (en) | 2015-10-01 | 2019-04-18 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| US10369292B2 (en) * | 2016-01-15 | 2019-08-06 | W. L. Gore & Associates, Inc. | Syringe plunger assemblies |
| EP3210630A1 (en) | 2016-02-29 | 2017-08-30 | G.L. Pharma GmbH | Abuse-deterrent pharmaceutical compositions |
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| EP3210596A1 (en) * | 2016-02-29 | 2017-08-30 | G.L. Pharma GmbH | Abuse-deterrent pharmaceutical composition |
| EP3426674A4 (en) | 2016-03-09 | 2019-08-14 | Blade Therapeutics, Inc. | CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| JP2019516773A (ja) | 2016-05-25 | 2019-06-20 | コンセントリック アナルジジックス，インク． | 改善された局所麻酔のための局所麻酔薬及び血管収縮薬と組み合わせたフェノールｔｒｐｖ１アゴニストのプロドラッグ |
| EP4067368A1 (en) | 2016-06-01 | 2022-10-05 | Athira Pharma, Inc. | Compounds |
| AU2017292646A1 (en) | 2016-07-05 | 2019-02-07 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| SG10201912574WA (en) | 2016-09-28 | 2020-02-27 | Blade Therapeutics Inc | Calpain modulators and therapeutic uses thereof |
| US11879019B2 (en) | 2016-12-19 | 2024-01-23 | The Regents Of The University Of California | Dual-enzyme responsive peptides |
| WO2018118903A1 (en) * | 2016-12-19 | 2018-06-28 | The Regents Of The University Of California | Noncrushable pill formulatiions |
| WO2018160178A1 (en) | 2017-03-01 | 2018-09-07 | Rgenix, Inc. | Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof |
| CA3056239C (en) | 2017-03-17 | 2023-09-12 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| MX2020008706A (es) * | 2018-02-23 | 2020-09-25 | Rhodes Tech | Nuevos compuestos de opioides y sus usos. |
| TW202019887A (zh) | 2018-07-27 | 2020-06-01 | 美商同心止痛劑股份有限公司 | 酚系trpv1促效劑之聚乙二醇化前藥 |
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- 2012-03-08 US US14/000,594 patent/US9139612B2/en active Active
- 2012-03-08 RU RU2013144368A patent/RU2608305C2/ru active
- 2012-03-08 AU AU2012225337A patent/AU2012225337B2/en active Active
- 2012-03-08 JP JP2013557882A patent/JP6148182B2/ja active Active
- 2012-03-08 EP EP12754373.4A patent/EP2683394B1/en active Active
- 2012-03-08 CA CA2827662A patent/CA2827662C/en active Active
- 2012-03-08 WO PCT/US2012/028367 patent/WO2012122422A2/en not_active Ceased
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|---|---|
| CN103813800B (zh) | 2017-12-19 |
| US20140121152A1 (en) | 2014-05-01 |
| EP2683394A2 (en) | 2014-01-15 |
| IL228215B (en) | 2019-01-31 |
| JP2014518546A (ja) | 2014-07-31 |
| BR112013022946A2 (pt) | 2017-07-18 |
| RU2608305C2 (ru) | 2017-01-17 |
| US9139612B2 (en) | 2015-09-22 |
| JP6148182B2 (ja) | 2017-06-14 |
| CN103813800A (zh) | 2014-05-21 |
| WO2012122422A2 (en) | 2012-09-13 |
| CA2827662C (en) | 2020-07-14 |
| EP2683394A4 (en) | 2015-06-03 |
| US20160002291A1 (en) | 2016-01-07 |
| EP2683394B1 (en) | 2021-01-06 |
| WO2012122422A3 (en) | 2014-04-24 |
| RU2013144368A (ru) | 2015-04-10 |
| CA2827662A1 (en) | 2012-09-13 |
| AU2012225337A1 (en) | 2013-05-09 |
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