AU2011379972B2 - Cysteamine in the treatment of fibrotic disease - Google Patents

Cysteamine in the treatment of fibrotic disease Download PDF

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Publication number
AU2011379972B2
AU2011379972B2 AU2011379972A AU2011379972A AU2011379972B2 AU 2011379972 B2 AU2011379972 B2 AU 2011379972B2 AU 2011379972 A AU2011379972 A AU 2011379972A AU 2011379972 A AU2011379972 A AU 2011379972A AU 2011379972 B2 AU2011379972 B2 AU 2011379972B2
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AU
Australia
Prior art keywords
antagonist
cysteamine
receptor
fibrosis
interstitial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU2011379972A
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English (en)
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AU2011379972A1 (en
Inventor
Allison A. Eddy
Daryl M. Okamura
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Seattle Childrens Hospital
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Seattle Childrens Hospital
Seattle Childrens Research Institute
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Publication date
Application filed by Seattle Childrens Hospital, Seattle Childrens Research Institute filed Critical Seattle Childrens Hospital
Publication of AU2011379972A1 publication Critical patent/AU2011379972A1/en
Application granted granted Critical
Publication of AU2011379972B2 publication Critical patent/AU2011379972B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2011379972A 2011-10-26 2011-10-26 Cysteamine in the treatment of fibrotic disease Expired - Fee Related AU2011379972B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/057935 WO2013062544A1 (en) 2011-10-26 2011-10-26 Cysteamine in the treatment of fibrotic disease

Publications (2)

Publication Number Publication Date
AU2011379972A1 AU2011379972A1 (en) 2014-05-15
AU2011379972B2 true AU2011379972B2 (en) 2016-05-12

Family

ID=48168215

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011379972A Expired - Fee Related AU2011379972B2 (en) 2011-10-26 2011-10-26 Cysteamine in the treatment of fibrotic disease

Country Status (7)

Country Link
US (2) US9468612B2 (https=)
AU (1) AU2011379972B2 (https=)
BR (1) BR112014009789A2 (https=)
CA (1) CA2853484C (https=)
IN (1) IN2014DN03049A (https=)
MX (1) MX2014004994A (https=)
WO (1) WO2013062544A1 (https=)

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* Cited by examiner, † Cited by third party
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EP3316877B1 (en) * 2015-07-02 2019-10-30 Horizon Orphan LLC Ado-resistant cysteamine analogs and uses thereof
CA3017797A1 (en) 2016-03-17 2017-09-21 Thiogenesis Therapeutics, Inc. Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders
US10155948B2 (en) * 2016-05-12 2018-12-18 Kangwon National University University-Industry Cooperation Foundation and Pharmaceutical composition for preventing or treating diabetic complications and screening method for preventive or therapeutic agent for diabetic complications
GB201609940D0 (en) * 2016-06-07 2016-07-20 Novabiotics Ltd Microparticles
US10905660B2 (en) 2016-06-07 2021-02-02 Novabiotics Limited Microparticles
WO2018148254A1 (en) * 2017-02-07 2018-08-16 Children's Hospital Medical Center Treatment of asthma with cysteamine
CA3076392A1 (en) 2017-09-20 2019-03-28 Thiogenesis Therapeutics, Inc. Methods for the treatment of cysteamine sensitive disorders
US10828372B2 (en) 2017-11-10 2020-11-10 Wisconsin Alumni Research Foundation Compositions and methods for the inhibition of fibrosis
WO2020079186A1 (en) 2018-10-17 2020-04-23 Novabiotics Limited Dosage regime
WO2020210218A1 (en) * 2019-04-12 2020-10-15 The Regents Of The University Of California Methods for treating inherited eye defects
WO2022081716A1 (en) * 2020-10-13 2022-04-21 Accubit LLC - Biotechnology Methods of treating iga nephropathy with thiol-containing molecules

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Also Published As

Publication number Publication date
AU2011379972A1 (en) 2014-05-15
CA2853484C (en) 2018-08-21
US20140275279A1 (en) 2014-09-18
CA2853484A1 (en) 2013-05-02
US20170165207A1 (en) 2017-06-15
US9925154B2 (en) 2018-03-27
MX2014004994A (es) 2014-08-27
IN2014DN03049A (https=) 2015-05-15
WO2013062544A1 (en) 2013-05-02
US9468612B2 (en) 2016-10-18
BR112014009789A2 (pt) 2017-04-25

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