IN2014DN03049A - - Google Patents

Info

Publication number
IN2014DN03049A
IN2014DN03049A IN3049DEN2014A IN2014DN03049A IN 2014DN03049 A IN2014DN03049 A IN 2014DN03049A IN 3049DEN2014 A IN3049DEN2014 A IN 3049DEN2014A IN 2014DN03049 A IN2014DN03049 A IN 2014DN03049A
Authority
IN
India
Prior art keywords
extracellular matrix
tissue
interstitial
expression
ecm
Prior art date
Application number
Inventor
Allison A Eddy
Daryl M Okamura
Original Assignee
Seattle Childrens Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Childrens Res Inst filed Critical Seattle Childrens Res Inst
Publication of IN2014DN03049A publication Critical patent/IN2014DN03049A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Fibrotic diseases are characterized by the replacement of healthy tissue with scar tissue and extracellular matrix in response to tissue damage. Here we describe the reduction of extracellular matrix (ECM) deposition interstitial fibroblasts interstitial volume expression of Collagen I mRNA and protein expression of profibrotic cytokines and macrophage infiltration by Cysteamine treatment.
IN3049DEN2014 2011-10-26 2011-10-26 IN2014DN03049A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/057935 WO2013062544A1 (en) 2011-10-26 2011-10-26 Cysteamine in the treatment of fibrotic disease

Publications (1)

Publication Number Publication Date
IN2014DN03049A true IN2014DN03049A (en) 2015-05-15

Family

ID=48168215

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3049DEN2014 IN2014DN03049A (en) 2011-10-26 2011-10-26

Country Status (7)

Country Link
US (2) US9468612B2 (en)
AU (1) AU2011379972B2 (en)
BR (1) BR112014009789A2 (en)
CA (1) CA2853484C (en)
IN (1) IN2014DN03049A (en)
MX (1) MX2014004994A (en)
WO (1) WO2013062544A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2770113T3 (en) 2015-07-02 2020-06-30 Horizon Orphan Llc ADO-resistant cysteamine analogues and their uses
CN117599029A (en) 2016-03-17 2024-02-27 硫创治疗公司 Compositions for controlled release of cysteamine and systematic treatment of cysteamine-sensitive disorders
US10155948B2 (en) * 2016-05-12 2018-12-18 Kangwon National University University-Industry Cooperation Foundation and Pharmaceutical composition for preventing or treating diabetic complications and screening method for preventive or therapeutic agent for diabetic complications
US10905660B2 (en) 2016-06-07 2021-02-02 Novabiotics Limited Microparticles
GB201609940D0 (en) * 2016-06-07 2016-07-20 Novabiotics Ltd Microparticles
US20200093764A1 (en) * 2017-02-07 2020-03-26 Children's Hospital Medical Center Treatment of asthma with cysteamine
WO2019060634A1 (en) 2017-09-20 2019-03-28 Thiogenesis Therapeutics, Inc. Methods for the treatment of cysteamine sensitive disorders
US10828372B2 (en) 2017-11-10 2020-11-10 Wisconsin Alumni Research Foundation Compositions and methods for the inhibition of fibrosis
WO2022081716A1 (en) * 2020-10-13 2022-04-21 Accubit LLC - Biotechnology Methods of treating iga nephropathy with thiol-containing molecules

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Also Published As

Publication number Publication date
CA2853484C (en) 2018-08-21
AU2011379972A1 (en) 2014-05-15
AU2011379972B2 (en) 2016-05-12
BR112014009789A2 (en) 2017-04-25
US9925154B2 (en) 2018-03-27
CA2853484A1 (en) 2013-05-02
MX2014004994A (en) 2014-08-27
US20170165207A1 (en) 2017-06-15
US9468612B2 (en) 2016-10-18
WO2013062544A1 (en) 2013-05-02
US20140275279A1 (en) 2014-09-18

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