AU2011317088B2 - Anti-folate receptor alpha antibody glycoforms - Google Patents
Anti-folate receptor alpha antibody glycoforms Download PDFInfo
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- AU2011317088B2 AU2011317088B2 AU2011317088A AU2011317088A AU2011317088B2 AU 2011317088 B2 AU2011317088 B2 AU 2011317088B2 AU 2011317088 A AU2011317088 A AU 2011317088A AU 2011317088 A AU2011317088 A AU 2011317088A AU 2011317088 B2 AU2011317088 B2 AU 2011317088B2
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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| US20060239910A1 (en) * | 2005-04-22 | 2006-10-26 | Morphotek Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| ES2766836T3 (es) * | 2012-05-15 | 2020-06-15 | Eisai Inc | Métodos para el tratamiento de cáncer gástrico |
| HRP20200482T1 (hr) * | 2012-08-31 | 2020-06-26 | Immunogen, Inc. | Dijagnostičke analize i setovi za detekciju folat receptora 1 |
| CA2893378A1 (en) * | 2012-12-07 | 2014-06-12 | Kyowa Hakko Kirin Co., Ltd. | Anti-folr1 antibody |
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| CA2921975C (en) | 2013-08-30 | 2024-02-13 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
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| MA40972B1 (fr) | 2014-11-20 | 2020-11-30 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t ciblant folr1 et cd3 |
| JP6944369B2 (ja) | 2014-11-20 | 2021-10-06 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｔ細胞活性化二重特異性抗原結合分子ｃｄ３ ａｂｄ葉酸受容体１（ｆｏｌｒ１）及びｐｄ−１軸結合アンタゴニストの併用療法 |
| PT3221357T (pt) | 2014-11-20 | 2020-07-28 | Hoffmann La Roche | Cadeias leves comuns e métodos de utilização |
| EP3227454B1 (en) | 2014-12-01 | 2020-01-29 | Amgen Inc. | Process for manipulating the level of glycan content of a glycoprotein |
| IL257531B2 (en) | 2015-09-17 | 2023-04-01 | Immunogen Inc | Medicinal compositions containing anti-folr1 immunoconjugates |
| EA202092125A1 (ru) | 2018-03-13 | 2020-12-15 | Фейнз Терапьютикс, Инк. | Антитела против рецептора фолата 1 и их применения |
| KR102275930B1 (ko) * | 2018-03-14 | 2021-07-12 | (주)알테오젠 | Folr1에 특이적으로 결합하는 항체 및 그의 용도 |
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| CN103242451B (zh) * | 2005-12-16 | 2017-11-21 | Ibc医药公司 | 基于免疫球蛋白的多价生物活性装配体 |
| WO2011116387A1 (en) * | 2010-03-19 | 2011-09-22 | Tetragenetics, Inc. | Production of aglycosylated monoclonal antibodies in ciliates |
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- 2011-10-19 MX MX2013004202A patent/MX2013004202A/es unknown
- 2011-10-19 CA CA2815080A patent/CA2815080A1/en not_active Abandoned
- 2011-10-19 JP JP2013535058A patent/JP2014505012A/ja active Pending
- 2011-10-19 KR KR1020137012669A patent/KR20140032944A/ko not_active Withdrawn
- 2011-10-19 RU RU2013122843/10A patent/RU2013122843A/ru not_active Application Discontinuation
- 2011-10-19 US US13/277,161 patent/US20120164137A1/en not_active Abandoned
- 2011-10-19 CN CN2011800503838A patent/CN103347537A/zh active Pending
- 2011-10-19 EP EP11835098.2A patent/EP2629798A4/en not_active Withdrawn
- 2011-10-19 BR BR112013009275A patent/BR112013009275A2/pt not_active Application Discontinuation
- 2011-10-19 WO PCT/US2011/056966 patent/WO2012054654A2/en not_active Ceased
- 2011-10-19 AU AU2011317088A patent/AU2011317088B2/en not_active Ceased
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| US20090274697A1 (en) * | 2004-02-12 | 2009-11-05 | Luigi Grasso | Monoclonal Antibodies That Specifically Block Biological Activity Of A Tumor Antigen |
| US20090324594A1 (en) * | 2005-04-22 | 2009-12-31 | Nicolaides Nicholas C | Antibodies With Immune Effector Activity And That Internalize In Folate Receptor Alpha-Positive Cells |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2014505012A (ja) | 2014-02-27 |
| MX2013004202A (es) | 2013-10-17 |
| EP2629798A4 (en) | 2014-05-28 |
| CN103347537A (zh) | 2013-10-09 |
| AU2011317088A1 (en) | 2013-05-02 |
| RU2013122843A (ru) | 2014-11-27 |
| WO2012054654A2 (en) | 2012-04-26 |
| CA2815080A1 (en) | 2012-04-26 |
| BR112013009275A2 (pt) | 2017-06-20 |
| IL225579A0 (en) | 2013-06-27 |
| EP2629798A2 (en) | 2013-08-28 |
| US20120164137A1 (en) | 2012-06-28 |
| WO2012054654A3 (en) | 2012-08-02 |
| AU2016202082A1 (en) | 2016-04-28 |
| KR20140032944A (ko) | 2014-03-17 |
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Owner name: EISAI, INC. Free format text: FORMER OWNER(S): MORPHOTEK, INC. |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |