AU2011200308B2 - Human antibody molecules for IL-13 - Google Patents

Human antibody molecules for IL-13 Download PDF

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Publication number
AU2011200308B2
AU2011200308B2 AU2011200308A AU2011200308A AU2011200308B2 AU 2011200308 B2 AU2011200308 B2 AU 2011200308B2 AU 2011200308 A AU2011200308 A AU 2011200308A AU 2011200308 A AU2011200308 A AU 2011200308A AU 2011200308 B2 AU2011200308 B2 AU 2011200308B2
Authority
AU
Australia
Prior art keywords
domain
seq
antibody
human
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2011200308A
Other languages
English (en)
Other versions
AU2011200308A1 (en
Inventor
Lutz Jermutuz
Ralph Raymond Minter
Phillip David Monk
Celia Patricia Shorrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune Ltd
Original Assignee
MedImmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0407315.1A external-priority patent/GB0407315D0/en
Application filed by MedImmune Ltd filed Critical MedImmune Ltd
Priority to AU2011200308A priority Critical patent/AU2011200308B2/en
Publication of AU2011200308A1 publication Critical patent/AU2011200308A1/en
Application granted granted Critical
Publication of AU2011200308B2 publication Critical patent/AU2011200308B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2011200308A 2003-07-15 2011-01-25 Human antibody molecules for IL-13 Expired AU2011200308B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011200308A AU2011200308B2 (en) 2003-07-15 2011-01-25 Human antibody molecules for IL-13

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US48751203P 2003-07-15 2003-07-15
US60/487,512 2003-07-15
US55821604P 2004-03-31 2004-03-31
US60/558,216 2004-03-31
GB0407315.1 2004-03-31
GBGB0407315.1A GB0407315D0 (en) 2003-07-15 2004-03-31 Human antibody molecules
US57379104P 2004-05-24 2004-05-24
US60/573,791 2004-05-24
PCT/GB2004/003059 WO2005007699A2 (en) 2003-07-15 2004-07-15 Human antibody molecules for il-13
AU2004256976A AU2004256976B2 (en) 2003-07-15 2004-07-15 Human antibody molecules for IL-13
AU2011200308A AU2011200308B2 (en) 2003-07-15 2011-01-25 Human antibody molecules for IL-13

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU2004256976A Division AU2004256976B2 (en) 2003-07-15 2004-07-15 Human antibody molecules for IL-13

Publications (2)

Publication Number Publication Date
AU2011200308A1 AU2011200308A1 (en) 2011-02-17
AU2011200308B2 true AU2011200308B2 (en) 2011-07-28

Family

ID=44535047

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011200308A Expired AU2011200308B2 (en) 2003-07-15 2011-01-25 Human antibody molecules for IL-13

Country Status (8)

Country Link
JP (3) JP5519567B2 (enExample)
KR (1) KR101073590B1 (enExample)
AU (1) AU2011200308B2 (enExample)
CY (1) CY1111467T1 (enExample)
HK (1) HK1216427A1 (enExample)
MX (1) MXPA06000258A (enExample)
NO (2) NO338853B1 (enExample)
RU (1) RU2009148270A (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016027797A2 (pt) * 2014-06-18 2017-10-31 Medimmune Llc métodos e meios de cultura de células compreendendo n-acetilcisteína

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0656947A1 (en) * 1992-08-21 1995-06-14 Schering Corporation Human interleukin-13
JP2005512522A (ja) * 2001-10-26 2005-05-12 セントカー・インコーポレーテツド Ｉｌ−１３ムテインタンパク質、抗体、組成物、方法および使用
US20030235555A1 (en) * 2002-04-05 2003-12-25 David Shealey Asthma-related anti-IL-13 immunoglobulin derived proteins, compositions, methods and uses
JP4723810B2 (ja) * 2001-12-03 2011-07-13 アレクシオン ファーマシューティカルズ， インコーポレイテッド ハイブリッド抗体
JP2006501249A (ja) * 2002-08-30 2006-01-12 グラクソ　グループ　リミテッド ワクチン
GB0407315D0 (en) * 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
TWI307630B (en) * 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins

Also Published As

Publication number Publication date
MXPA06000258A (es) 2006-07-03
HK1155185A1 (en) 2012-05-11
NO342727B1 (no) 2018-07-30
JP5922686B2 (ja) 2016-05-24
NO20060730L (no) 2006-04-10
AU2011200308A1 (en) 2011-02-17
JP2016047843A (ja) 2016-04-07
KR101073590B1 (ko) 2011-10-14
JP2011147454A (ja) 2011-08-04
NO20160707A1 (no) 2016-04-27
JP5519567B2 (ja) 2014-06-11
HK1216427A1 (zh) 2016-11-11
JP2014101372A (ja) 2014-06-05
KR20060054312A (ko) 2006-05-22
NO338853B1 (no) 2016-10-24
HK1097853A1 (en) 2007-07-06
CY1111467T1 (el) 2015-08-05
RU2009148270A (ru) 2011-06-27

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired