AU2010305399B2 - Method for the synthesis of ergothioneine and the like - Google Patents

Method for the synthesis of ergothioneine and the like Download PDF

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Publication number
AU2010305399B2
AU2010305399B2 AU2010305399A AU2010305399A AU2010305399B2 AU 2010305399 B2 AU2010305399 B2 AU 2010305399B2 AU 2010305399 A AU2010305399 A AU 2010305399A AU 2010305399 A AU2010305399 A AU 2010305399A AU 2010305399 B2 AU2010305399 B2 AU 2010305399B2
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AU
Australia
Prior art keywords
compound
formula
mixture
acid
betaine type
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Ceased
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AU2010305399A
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English (en)
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AU2010305399A1 (en
Inventor
Irene Erdelmeier
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Tetrahedron SAS
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Tetrahedron SAS
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Publication of AU2010305399A1 publication Critical patent/AU2010305399A1/en
Application granted granted Critical
Publication of AU2010305399B2 publication Critical patent/AU2010305399B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2010305399A 2009-10-06 2010-10-06 Method for the synthesis of ergothioneine and the like Ceased AU2010305399B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0956962 2009-10-06
FR0956962A FR2950889B1 (fr) 2009-10-06 2009-10-06 Procede de synthese de l'ergothioneine et analogues
PCT/EP2010/064950 WO2011042480A1 (fr) 2009-10-06 2010-10-06 Procede de synthese de l'ergothioneine et analogues

Publications (2)

Publication Number Publication Date
AU2010305399A1 AU2010305399A1 (en) 2012-05-17
AU2010305399B2 true AU2010305399B2 (en) 2014-06-12

Family

ID=41650166

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010305399A Ceased AU2010305399B2 (en) 2009-10-06 2010-10-06 Method for the synthesis of ergothioneine and the like

Country Status (13)

Country Link
US (1) US8399500B2 (enExample)
EP (1) EP2486020B1 (enExample)
JP (2) JP5813647B2 (enExample)
KR (1) KR101832396B1 (enExample)
CN (1) CN102686568B (enExample)
AU (1) AU2010305399B2 (enExample)
BR (1) BR112012007869B1 (enExample)
CA (1) CA2776836C (enExample)
ES (1) ES2646331T3 (enExample)
FR (1) FR2950889B1 (enExample)
IN (1) IN2012DN03818A (enExample)
RU (1) RU2550202C2 (enExample)
WO (1) WO2011042480A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2950890B1 (fr) 2009-10-06 2011-12-30 Tetrahedron Procede de synthese de la 2-thiohistidine et analogues
WO2014100752A1 (en) * 2012-12-21 2014-06-26 Liu Pinghua Ergothioneine production through metabolic engineering
US10544437B2 (en) 2014-04-29 2020-01-28 Conagen Inc. Microbial ergothioneine biosynthesis
FR3021655B1 (fr) 2014-05-30 2016-07-08 Tetrahedron Nouveaux composes de type 5-acylsulfanyl-histidine en tant que precurseurs des 5-sulfanylhistidines correspondantes et de leurs disulfures
GB201416678D0 (en) 2014-09-22 2014-11-05 Univ Cape Town Process For Synthesizing Ergothioneine And Its Intermediates
CN107848984B (zh) 2015-03-13 2021-08-24 米洛诺瓦创新有限责任公司 用于制备麦角硫因化合物的Nα,Nα,Nα-三烷基组氨酸衍生物
BR112022000183A2 (pt) 2019-07-10 2022-02-22 Kureha Corp Regulador de crescimento de plantal e método para promover o crescimento de planta
JP6864131B1 (ja) * 2020-03-04 2021-04-28 長瀬産業株式会社 Ｌ−エルゴチオネイン含有組成物
KR20220081067A (ko) 2020-12-08 2022-06-15 코오롱인더스트리 주식회사 에르고티오네인 생산능이 향상된 재조합 효모 및 이를 이용한 에르고티오네인의 생산 방법
CN117729918A (zh) * 2021-07-28 2024-03-19 南京纽邦生物科技有限公司 L-麦角硫因及其用途
AU2022430726A1 (en) 2022-01-06 2024-07-25 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Use of ergothioneine for enhancing glutathione level
US11491141B1 (en) 2022-01-06 2022-11-08 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Methods of treating glutathione deficiencies and deficiencies in glutathione synthetase activity
WO2023201707A1 (en) * 2022-04-22 2023-10-26 Nanjing Nutrabuilding Bio-Tech Co., Ltd. Process for chemical synthesis of ergothioneine and methods of use
JP7752245B2 (ja) 2022-07-06 2025-10-09 株式会社クレハ 植物生長調整剤、植物の生長促進方法または植物生長調整用製品
AR130564A1 (es) 2022-09-27 2024-12-18 Kureha Corp Agente para mejorar la tolerancia al estrés ambiental en una planta y método para mejorar la tolerancia al estrés ambiental en una planta
CN116102502A (zh) * 2022-11-28 2023-05-12 南京艾希帝生物科技有限公司 一种麦角硫因的合成方法
AR134099A1 (es) 2023-10-16 2025-12-03 Kureha Corp Método para tratar una planta, formulación, propágulo de una planta, método para cultivar una planta, y plántula de trasplante
AR134409A1 (es) 2023-11-21 2026-01-14 Kureha Corp Mejorador de tolerancia al estrés abiótico de una planta, método para mejorar la tolerancia al estrés abiótico, formulación para mejorar la tolerancia al estrés abiótico, producto para mejorar la tolerancia al estrés abiótico, y planta
AR134410A1 (es) 2023-11-21 2026-01-14 Kureha Corp Agente para mejorar la recuperabilidad de daño y formulación para mejorar la recuperabilidad de daño de la planta, método para mejorar la recuperabilidad de daño de la planta, cuerpo de la planta y agente para mejorar la tolerancia al estrés físico de la planta
WO2025143153A1 (ja) 2023-12-27 2025-07-03 株式会社クレハ 植物の生育期間短縮化剤および生育期間短縮用の製剤、花成誘導遺伝子の発現誘導剤、植物の生育期間を短縮化させる方法、植物体、植物の生育速度の均一化剤、ならびに植物の生育速度を均一化させる方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707087B1 (fr) * 1993-06-28 1995-10-13 Bioxytech Nouveau procédé de préparation de l'ergothionéine.
GB9811427D0 (en) * 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds
KR20070063016A (ko) * 2004-09-24 2007-06-18 알러간, 인코포레이티드 알파2 아드레날린성 아고니스트로서 작용하는 4-(축합시클릭메틸)-이미다졸-2-티온
US7115748B2 (en) * 2004-12-07 2006-10-03 Allergan, Inc. Method of making imidazole-2-thiones
US7767826B2 (en) * 2007-10-05 2010-08-03 Pharmatech International, Inc. Process for the synthesis of L-(+)-ergothioneine
JP2009161498A (ja) * 2008-01-10 2009-07-23 Univ Nagoya エルゴチオネインの製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ishikawa Y. et al, Joural of Biological Chemistry, 1974, 249(14), 4420-4427 *
Shosuke I., J. Org. Chem., 1985, 50, 3636-3638 *

Also Published As

Publication number Publication date
FR2950889B1 (fr) 2011-11-18
JP2016006099A (ja) 2016-01-14
BR112012007869B1 (pt) 2021-10-13
EP2486020A1 (fr) 2012-08-15
IN2012DN03818A (enExample) 2015-08-28
CN102686568B (zh) 2015-03-18
AU2010305399A1 (en) 2012-05-17
CN102686568A (zh) 2012-09-19
FR2950889A1 (fr) 2011-04-08
KR20120091187A (ko) 2012-08-17
JP5813647B2 (ja) 2015-11-17
WO2011042480A1 (fr) 2011-04-14
RU2550202C2 (ru) 2015-05-10
US20120136159A1 (en) 2012-05-31
ES2646331T3 (es) 2017-12-13
CA2776836C (fr) 2019-01-15
KR101832396B1 (ko) 2018-02-26
JP2013506706A (ja) 2013-02-28
EP2486020B1 (fr) 2017-08-16
CA2776836A1 (fr) 2011-04-14
RU2012117978A (ru) 2013-11-20
US8399500B2 (en) 2013-03-19
BR112012007869A2 (pt) 2015-09-22

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired