AU2010275196B2 - Fused aminodihydropyrimidone derivatives - Google Patents

Fused aminodihydropyrimidone derivatives Download PDF

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Publication number
AU2010275196B2
AU2010275196B2 AU2010275196A AU2010275196A AU2010275196B2 AU 2010275196 B2 AU2010275196 B2 AU 2010275196B2 AU 2010275196 A AU2010275196 A AU 2010275196A AU 2010275196 A AU2010275196 A AU 2010275196A AU 2010275196 B2 AU2010275196 B2 AU 2010275196B2
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AU
Australia
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group
optionally
compound
substituents selected
substituent group
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Ceased
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AU2010275196A
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English (en)
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AU2010275196A1 (en
Inventor
Jose Luis Castro Pineiro
Adrian Hall
Andrew Madin
Ngoc-Tri Vo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of AU2010275196A1 publication Critical patent/AU2010275196A1/en
Application granted granted Critical
Publication of AU2010275196B2 publication Critical patent/AU2010275196B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2010275196A 2009-07-22 2010-07-21 Fused aminodihydropyrimidone derivatives Ceased AU2010275196B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0912777.0 2009-07-22
GB0912777A GB0912777D0 (en) 2009-07-22 2009-07-22 Fused aminodihydropyrimidone derivatives
PCT/EP2010/060586 WO2011009897A1 (en) 2009-07-22 2010-07-21 Fused aminodihydropyrimidone derivatives

Publications (2)

Publication Number Publication Date
AU2010275196A1 AU2010275196A1 (en) 2012-02-16
AU2010275196B2 true AU2010275196B2 (en) 2015-08-06

Family

ID=41058390

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010275196A Ceased AU2010275196B2 (en) 2009-07-22 2010-07-21 Fused aminodihydropyrimidone derivatives

Country Status (10)

Country Link
US (1) US9139594B2 (enExample)
EP (1) EP2456771A1 (enExample)
JP (1) JP5699146B2 (enExample)
KR (1) KR20120052343A (enExample)
CN (1) CN102574864B (enExample)
AU (1) AU2010275196B2 (enExample)
CA (1) CA2768881A1 (enExample)
GB (1) GB0912777D0 (enExample)
IN (1) IN2012DN00688A (enExample)
WO (1) WO2011009897A1 (enExample)

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US8198269B2 (en) 2008-09-30 2012-06-12 Eisai R&D Management Co., Ltd. Fused aminodihydrothiazine derivative
WO2010047372A1 (ja) 2008-10-22 2010-04-29 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２－アミノピリミジン－４－オンおよび２－アミノピリジン誘導体
GB0912777D0 (en) 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydropyrimidone derivatives
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EP2694521B1 (en) 2011-04-07 2015-11-25 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
EP2694489B1 (en) 2011-04-07 2017-09-06 Merck Sharp & Dohme Corp. C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
CN103608345A (zh) 2011-04-26 2014-02-26 盐野义制药株式会社 噁嗪衍生物和含有该噁嗪衍生物的bace1抑制剂
JP2014524472A (ja) 2011-08-22 2014-09-22 メルク・シャープ・アンド・ドーム・コーポレーション Ｂａｃｅ阻害剤としての２−スピロ置換イミノチアジンならびにそのモノオキシドおよびジオキシド、組成物、ならびにそれらの使用
SG11201406589PA (en) 2012-04-27 2014-11-27 Eisai R&D Man Co Ltd Method for producing 5-(difluoromethyl)pyrazine-2-carboxilic acid and production intermediate thereof
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JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
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Also Published As

Publication number Publication date
AU2010275196A1 (en) 2012-02-16
EP2456771A1 (en) 2012-05-30
IN2012DN00688A (enExample) 2015-06-19
US9139594B2 (en) 2015-09-22
JP5699146B2 (ja) 2015-04-08
KR20120052343A (ko) 2012-05-23
US20120202828A1 (en) 2012-08-09
WO2011009897A1 (en) 2011-01-27
CN102574864A (zh) 2012-07-11
GB0912777D0 (en) 2009-08-26
JP2012533602A (ja) 2012-12-27
CA2768881A1 (en) 2011-01-27
CN102574864B (zh) 2015-04-29

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired