AU2010270722B2 - Methods for preparing vesicles and formulations produced therefrom - Google Patents
Methods for preparing vesicles and formulations produced therefrom Download PDFInfo
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- AU2010270722B2 AU2010270722B2 AU2010270722A AU2010270722A AU2010270722B2 AU 2010270722 B2 AU2010270722 B2 AU 2010270722B2 AU 2010270722 A AU2010270722 A AU 2010270722A AU 2010270722 A AU2010270722 A AU 2010270722A AU 2010270722 B2 AU2010270722 B2 AU 2010270722B2
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- antigen
- vesicle
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- hepatitis
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2766521C (en) * | 2009-06-25 | 2020-07-21 | Revance Therapeutics, Inc. | Albumin-free botulinum toxin formulations |
| US9849173B2 (en) | 2009-07-06 | 2017-12-26 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
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| JP6119030B2 (ja) | 2010-07-06 | 2017-04-26 | ヴァリエーション バイオテクノロジーズ インコーポレイテッド | インフルエンザを治療するための組成物及び方法 |
| MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
| CA2890084C (en) * | 2011-11-18 | 2021-05-04 | Maura Ellen Campbell | Synthetic derivatives of mpl and uses thereof |
| CA2894442C (en) | 2012-01-12 | 2020-01-21 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| US20150079077A1 (en) | 2012-01-27 | 2015-03-19 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
| JP5650780B2 (ja) * | 2012-04-04 | 2015-01-07 | 日東電工株式会社 | ワクチン組成物 |
| US9017698B2 (en) | 2013-09-25 | 2015-04-28 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9149522B2 (en) | 2013-09-25 | 2015-10-06 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| US9504743B2 (en) | 2013-09-25 | 2016-11-29 | Sequoia Sciences, Inc | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
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| CN105792843B (zh) * | 2013-11-29 | 2020-02-28 | 泰尔茂株式会社 | 佐剂组合物及包含其的疫苗组合物、以及它们的制造方法 |
| WO2016149417A1 (en) * | 2015-03-17 | 2016-09-22 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| AU2016273638B2 (en) * | 2015-06-02 | 2019-06-06 | Terumo Kabushiki Kaisha | Adjuvant composition containing aluminum and vaccine composition containing the same |
| GB201612108D0 (en) * | 2016-07-12 | 2016-08-24 | Univ Strathclyde | Preperation of non-ionic surfactant vesicles and variants |
| GB201814959D0 (en) * | 2018-09-14 | 2018-10-31 | Secr Defence | Methods for the preparation of a pharmaceutical-vesicle formulation and associated products and uses |
| CN116211827B (zh) * | 2023-03-17 | 2024-04-05 | 浙江大学 | 一种特立帕肽固体脂质纳米粒及其制备方法和应用 |
| WO2024226846A2 (en) * | 2023-04-26 | 2024-10-31 | Vivtex Corporation | Formulation of therapeutic agents for improved permeation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5910306A (en) * | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
| WO2010033812A1 (en) * | 2008-09-18 | 2010-03-25 | Variation Biotechnologies, Inc. | Compositions and methods for treating hepatitis a. |
Family Cites Families (136)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024241A (en) | 1974-09-27 | 1977-05-17 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| US3952097A (en) | 1974-09-27 | 1976-04-20 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| US4349538A (en) | 1979-12-07 | 1982-09-14 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| JPS56115727A (en) * | 1980-02-19 | 1981-09-11 | Kuraray Co Ltd | Carrier for immobilizing physiologically active substance |
| US4537769A (en) | 1982-04-06 | 1985-08-27 | American Cyanamid Company | Stabilization of influenza virus vaccine |
| US4894228A (en) | 1982-04-07 | 1990-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against hepatitis A virus |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4983387A (en) | 1986-05-19 | 1991-01-08 | Viral Technologies Inc. | HIV related peptides, immunogenic antigens, and use therefor as subunit vaccine for AIDS virus |
| DE3867635D1 (de) | 1987-03-13 | 1992-02-20 | Micro Vesicular Systems | Lipidversikel aus grenzflaechenaktiven stoffen und sterolen. |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US5160669A (en) | 1988-03-03 | 1992-11-03 | Micro Vesicular Systems, Inc. | Method of making oil filled paucilamellar lipid vesicles |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US4911517A (en) | 1988-09-09 | 1990-03-27 | Square D Company | Means for clamping fiber optical cable |
| US5549910A (en) | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
| US5817318A (en) | 1989-05-03 | 1998-10-06 | Connaught Laboratories Limited | Synthetic peptides for an HIV-1 vaccine |
| CN1022331C (zh) | 1989-08-17 | 1993-10-06 | 浙江省医学科学院 | 甲型肝炎减毒活疫苗毒种及其制造方法 |
| DE3934366A1 (de) | 1989-10-14 | 1991-04-18 | Chemotherapeutisches Forschungsinstitut Georg Speyer Haus | Vakzine zum schutz vor hiv-virusinfektionen, verfahren zu ihrer herstellung und ihre verwendung als diagnostikum und immuntherapeutikum |
| IT1238343B (it) | 1989-10-16 | 1993-07-13 | Cesalpino Andrea Fond | Procedimento per la preparazione di vaccini capaci di generare non solo la risposta immune dei linfociti t helper,ma anche un'efficace risposta di linfociti t citotossici,e vaccini con queste caratteristiche |
| IE904098A1 (en) | 1989-11-13 | 1991-05-22 | Nova Pharm Corp | Lipospheres for controlled delivery of substances |
| FI925835L (fi) | 1990-06-29 | 1992-12-22 | Chiron Corp | Vacciner innehaollande liposomer |
| US5250236A (en) | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
| GB9207731D0 (en) | 1992-04-07 | 1992-05-27 | Proteus Molecular Design | Improvements in or relating to vaccines |
| AU4327193A (en) | 1992-07-08 | 1994-01-31 | Dianorm-Gerate G. Maierhofer | Liposomes, method of preparing them and their use in the preparation of drugs |
| ES2164074T3 (es) | 1992-09-18 | 2002-02-16 | Smithkline Beecham Biolog | Vacunas de virus de la hepatitis a. |
| US5393527A (en) | 1993-01-04 | 1995-02-28 | Becton, Dickinson And Company | Stabilized microspheres and methods of preparation |
| EP0688206B1 (en) | 1993-02-26 | 2000-05-03 | Fountain Pharmaceuticals, Inc. | Vaccine delivery system and shelf-stable precursor solution for remote encapsulation of active ingredients |
| US5885486A (en) * | 1993-03-05 | 1999-03-23 | Pharmaciaand Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| EP0706374B1 (en) | 1993-06-30 | 1997-12-10 | Genentech, Inc. | Method for preparing liposomes |
| US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| GB9320597D0 (en) * | 1993-10-06 | 1993-11-24 | Proteus Molecular Design | Improvements in and realting to vaccines |
| CN1055093C (zh) | 1993-11-17 | 2000-08-02 | 实验室奥姆公司 | 葡糖胺二糖类、其制备方法和用途、以及含有这些二糖的药物组合物 |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| EP0733113B1 (en) | 1994-01-11 | 2007-05-02 | Vlaams Interuniversitair Instituut voor Biotechnologie | Influenza vaccine |
| US5824536A (en) | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| US6235888B1 (en) | 1994-10-05 | 2001-05-22 | The General Hospital Corporation | Hepatitis C virus vaccine |
| US20030104576A1 (en) | 1994-10-07 | 2003-06-05 | Jonathan W. Nyce | Dna construct, composition, formulations & methods for making the construct & for modulating expression |
| GB9515868D0 (en) | 1995-08-02 | 1995-10-04 | Proteus Molecular Design | Therapeutic method |
| GB9522351D0 (en) | 1995-11-01 | 1996-01-03 | Medeva Holdings Bv | Vaccine compositions |
| US5700679A (en) | 1996-06-07 | 1997-12-23 | Novavax, Inc. | Lipid vesicles having a bilayer containing a surfactant with anti-viral and spermicidal activity |
| US5919480A (en) | 1996-06-24 | 1999-07-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposomal influenza vaccine composition and method |
| US6235724B1 (en) | 1996-07-03 | 2001-05-22 | Eisai Co., Ltd. | Injections containing lipid a analogues and process for the preparation thereof |
| ZA975889B (en) | 1996-07-08 | 1998-02-23 | Genentech Inc | HIV envelope polypeptides and vaccine. |
| ES2305157T3 (es) * | 1996-09-13 | 2008-11-01 | Lipoxen Technologies Limited | Liposomas. |
| US6290967B1 (en) | 1996-12-20 | 2001-09-18 | Merck & Co., Inc. | Stabilizers for lyophilized vaccines |
| FR2760367B1 (fr) | 1997-03-06 | 1999-04-30 | Pasteur Merieux Serums Vacc | Composition vaccinale destinee a la prevention ou au traitement des hepatites c |
| TW570803B (en) | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
| US6303347B1 (en) | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US6764840B2 (en) | 1997-05-08 | 2004-07-20 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| DE69828507T2 (de) | 1997-05-20 | 2006-01-05 | Galenica Pharmaceuticals, Inc. | Triterpene-saponin analoga mit adjuvans und immunostimulierender wirkung |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
| ATE365206T1 (de) | 1998-02-13 | 2007-07-15 | Adan Rios | Verfahren zur entwicklung von einem hiv impfstoff |
| US6503753B1 (en) | 1998-02-13 | 2003-01-07 | Adan Rios | Method for the development of an HIV vaccine |
| EP1078105B1 (en) | 1998-05-12 | 2004-11-24 | Genecure LLC | Replication defective hiv vaccine |
| US7067134B1 (en) | 1998-08-12 | 2006-06-27 | University Of Western Ontario | HIV vaccine |
| AT408615B (de) | 1998-09-15 | 2002-01-25 | Immuno Ag | Neue influenzavirus-impfstoffzusammensetzung |
| GB9822714D0 (en) | 1998-10-16 | 1998-12-09 | Smithkline Beecham Sa | Vaccines |
| CN1062770C (zh) | 1998-11-12 | 2001-03-07 | 卫生部长春生物制品研究所 | 甲肝-麻疹二联疫苗及其生产方法 |
| US6287570B1 (en) | 1998-11-23 | 2001-09-11 | Patricia L. Foley | Vaccine against swine influenza virus |
| GB9826069D0 (en) | 1998-11-28 | 1999-01-20 | Univ Leeds | HIV vaccine |
| IL127331A0 (en) | 1998-11-30 | 1999-09-22 | Yeda Res & Dev | Peptide-based vaccine for influenza |
| US6551600B2 (en) | 1999-02-01 | 2003-04-22 | Eisai Co., Ltd. | Immunological adjuvant compounds compositions and methods of use thereof |
| US20040006242A1 (en) | 1999-02-01 | 2004-01-08 | Hawkins Lynn D. | Immunomodulatory compounds and method of use thereof |
| AT407958B (de) | 1999-02-11 | 2001-07-25 | Immuno Ag | Inaktivierte influenza-virus-vakzine zur nasalen oder oralen applikation |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| NO311807B1 (no) | 1999-03-04 | 2002-01-28 | Bionor Immuno As | HIV-peptider, antigener, vaksinepreparater, immunoassay- testsett og en metode for påvisning av antistoffer fremkalt av HIV |
| EP1200622A4 (en) | 1999-07-06 | 2004-12-22 | Merck & Co Inc | HIV VACCINE FROM AN ADENOVIRUS CARRYING THE GAG GENE |
| WO2001005433A2 (en) * | 1999-07-14 | 2001-01-25 | Board Of Regents, The University Of Texas System | Delivery and retention of activity agents to lymph nodes |
| AU771706B2 (en) | 1999-07-15 | 2004-04-01 | University Of British Columbia, The | Methods and apparatus for preparation of lipid vesicles |
| AU779076B2 (en) | 1999-07-28 | 2005-01-06 | Stephen Smith | Conditionally controlled, attenuated HIV vaccine |
| NZ517903A (en) | 1999-09-24 | 2003-10-31 | Smithkline Beecham Biolog S | One dose intranasal influenza virus vaccine with split influenza viral antigens |
| WO2001060402A2 (en) | 2000-02-15 | 2001-08-23 | Intellivax International Inc. | Proteosome influenza vaccine |
| FR2806912B1 (fr) | 2000-04-04 | 2004-07-23 | Fond Mondiale Rech Et Preventi | UTILISATION DE PROTEINES gp120 ET gp160 MODIFIEES DANS LA BOUCLE V3 DU VIH-1 POUR LA PREPARATION DE COMPOSITIONS VACCINALES ET FORMULATIONS LES CONTENANT |
| US20030092145A1 (en) | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
| US7494659B2 (en) | 2000-09-25 | 2009-02-24 | Polymun Scientific Immunbiologische Forschung Gmbh | Live attenuated influenza vaccine |
| ATE374603T1 (de) | 2000-12-27 | 2007-10-15 | Ares Trading Sa | Amphiphile lipid-nanopartikel zur peptid- und/oder proteininkorporation |
| GB0111279D0 (en) * | 2001-05-10 | 2001-06-27 | Nycomed Imaging As | Radiolabelled liposomes |
| TWI228420B (en) | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
| US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US7850990B2 (en) * | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| ES2339762T3 (es) | 2002-01-14 | 2010-05-25 | Novartis Vaccines And Diagnostics, Inc. | Vacuna contra el vih y procedimiento de uso. |
| US7285289B2 (en) | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
| US20050169979A1 (en) | 2002-07-03 | 2005-08-04 | Dov Michaeli | Liposomal vaccine |
| US7604803B2 (en) | 2002-07-05 | 2009-10-20 | Lipoxen Technologies Limited | Method to enhance an immune response of nucleic acid vaccination |
| US20040011840A1 (en) | 2002-07-22 | 2004-01-22 | Lovett Terry E. | Rolling motorcycle bag |
| EP1597400B8 (en) | 2003-02-25 | 2013-10-09 | MedImmune, LLC | Methods of producing influenza vaccine compositions |
| NZ543467A (en) | 2003-04-10 | 2008-07-31 | Novartis Vaccines & Diagnostic | The severe acute respiratory syndrome coronavirus |
| CN1925870A (zh) | 2003-05-15 | 2007-03-07 | 俄克拉荷马州大学评议会 | 表达马－2型流感病毒ha1的dna疫苗 |
| AU2004246904B2 (en) | 2003-06-18 | 2010-02-04 | Biolab Ltd. | Sphingolipids polyalkylamine conjugates for use in transfection |
| US7368537B2 (en) | 2003-07-15 | 2008-05-06 | Id Biomedical Corporation Of Quebec | Subunit vaccine against respiratory syncytial virus infection |
| GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| US20050095283A1 (en) | 2003-09-16 | 2005-05-05 | Aphios Corporation | Compositions and methods for topically treating diseases |
| US20080160089A1 (en) | 2003-10-14 | 2008-07-03 | Medivas, Llc | Vaccine delivery compositions and methods of use |
| US7498309B2 (en) * | 2003-11-29 | 2009-03-03 | Sangstat Medical Corporation | Pharmaceutical compositions for bioactive peptide agents |
| AU2005248361B2 (en) * | 2004-05-18 | 2010-03-11 | Vical Incorporated | Influenza virus vaccine composition and methods of use |
| EP2530147B1 (en) | 2004-05-25 | 2014-09-10 | MedImmune, LLC | Influenza hemagglutinin and neuraminidase variants |
| DE602005025342D1 (de) | 2004-05-28 | 2011-01-27 | Glaxosmithkline Biolog Sa | Impfstoffzusammensetzungen mit virosomen und einem saponin-adjuvans |
| WO2006002642A2 (en) * | 2004-07-07 | 2006-01-12 | Statens Serum Institut | Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids |
| EP1809246B1 (en) * | 2004-10-08 | 2008-07-16 | Alza Corporation | Method of insertion of a lipid-linked moiety into a pre-formed lipid assembly using microwaves |
| KR101316350B1 (ko) | 2004-12-08 | 2013-10-15 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
| EP1676569A1 (en) | 2004-12-30 | 2006-07-05 | Pevion Biotech Ltd. | Lyophilization of virosomes |
| WO2006092046A1 (en) | 2005-03-01 | 2006-09-08 | Variation Biotechnologies Inc. | Hiv vaccine composition |
| JP2006248978A (ja) * | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| US20090028903A1 (en) | 2005-03-23 | 2009-01-29 | Glaxosmithkline Biologicals, S.A. | Novel use |
| US7348011B2 (en) | 2005-06-10 | 2008-03-25 | Sudershan Biotech Ltd. | Hepatitis C virus vaccine |
| WO2006138719A2 (en) | 2005-06-17 | 2006-12-28 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
| WO2007062107A2 (en) | 2005-11-25 | 2007-05-31 | Coley Pharmaceutical Gmbh | Immunostimulatory oligoribonucleotides |
| WO2007120368A2 (en) * | 2006-01-09 | 2007-10-25 | The Regents Of The University Of California | Immunostimulatory combinations for vaccine adjuvants |
| EP1988918A4 (en) | 2006-02-22 | 2010-04-28 | Novavax Inc | ADJUVANZ AND VACCINE COMPOSITIONS |
| US8846078B2 (en) * | 2006-03-21 | 2014-09-30 | The Secretary Of State For Environment, Food & Rural Affairs Acting Through The Animal Health And Veterinary Laboratories Agency | Brucellosis DNA vaccine |
| CN101448523A (zh) | 2006-03-24 | 2009-06-03 | 诺华疫苗和诊断有限两合公司 | 无需冷藏储存流感疫苗 |
| JP5072275B2 (ja) * | 2006-07-03 | 2012-11-14 | テルモ株式会社 | 閉鎖小胞の分離方法、製剤の製造方法および評価方法 |
| AU2007340343A1 (en) | 2006-09-05 | 2008-07-10 | Medivas, Llc | Polymer-stabilized liposomal compositions and methods of use |
| US8273361B2 (en) * | 2006-09-26 | 2012-09-25 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| CN101687900A (zh) | 2007-03-07 | 2010-03-31 | 恩文塔生物制药公司 | 双链锁核酸组合物 |
| WO2008121926A1 (en) | 2007-03-30 | 2008-10-09 | Particle Sciences, Inc. | Particle formulations and uses thereof |
| WO2008153236A1 (en) | 2007-06-15 | 2008-12-18 | Protheon Co., Ltd | An attenuated influenza virus and a live vaccine comprising the same |
| EP2014279A1 (en) | 2007-06-22 | 2009-01-14 | Pevion Biotech AG | Virosomes comprising hemagglutinin derived from an influenza virus produced in a cell line, compositions, methods of manufacturing, use thereof |
| SI2192917T1 (sl) | 2007-08-28 | 2014-05-30 | Baxter International Inc. | Postopek za proizvodnjo virusnih cepiv |
| US20110105995A1 (en) | 2008-01-16 | 2011-05-05 | Zhu Ting F | Uniform-sized, multi-drug carrying, and photosensitive liposomes for advanced drug delivery |
| CN101574394A (zh) | 2008-05-09 | 2009-11-11 | 北京因科瑞斯医药科技有限公司 | 马钱子生物碱囊泡及其制备方法 |
| JP5775451B2 (ja) | 2008-06-19 | 2015-09-09 | バリエーション バイオテクノロジーズ インコーポレイティド | インフルエンザを処置するための組成物および方法 |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| WO2011005772A1 (en) | 2009-07-06 | 2011-01-13 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| US9849173B2 (en) | 2009-07-06 | 2017-12-26 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
| WO2012006368A2 (en) | 2010-07-06 | 2012-01-12 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
| JP6119030B2 (ja) | 2010-07-06 | 2017-04-26 | ヴァリエーション バイオテクノロジーズ インコーポレイテッド | インフルエンザを治療するための組成物及び方法 |
| MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
| US20130323280A1 (en) | 2011-01-13 | 2013-12-05 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| CA2894442C (en) | 2012-01-12 | 2020-01-21 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| US20150079077A1 (en) | 2012-01-27 | 2015-03-19 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5910306A (en) * | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
| WO2010033812A1 (en) * | 2008-09-18 | 2010-03-25 | Variation Biotechnologies, Inc. | Compositions and methods for treating hepatitis a. |
Non-Patent Citations (1)
| Title |
|---|
| Mann, J. F. S. et al., Vaccine, 2004, Vol. 22, pages 2425-2429 * |
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| BR112012000826A2 (pt) | 2016-08-09 |
| US20120156240A1 (en) | 2012-06-21 |
| WO2011005769A9 (en) | 2014-08-21 |
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| CN102482666B (zh) | 2017-02-08 |
| IL247238B (en) | 2021-03-25 |
| EP2451950B9 (en) | 2016-11-23 |
| IL247238A0 (en) | 2016-09-29 |
| CA2767392A1 (en) | 2011-01-13 |
| IL217375A (en) | 2016-08-31 |
| ES2573427T3 (es) | 2016-06-07 |
| IL217375A0 (en) | 2012-02-29 |
| JP5854559B2 (ja) | 2016-02-09 |
| EP2451950B1 (en) | 2016-03-02 |
| US9849173B2 (en) | 2017-12-26 |
| JP2012532200A (ja) | 2012-12-13 |
| EP2451950A4 (en) | 2013-08-14 |
| AU2010270722A1 (en) | 2012-03-01 |
| EP2451950A1 (en) | 2012-05-16 |
| ES2573427T9 (es) | 2017-03-17 |
| CN107029229A (zh) | 2017-08-11 |
| WO2011005769A1 (en) | 2011-01-13 |
| BR112012000826B1 (pt) | 2022-07-26 |
| CN107029229B (zh) | 2022-08-26 |
| CN102482666A (zh) | 2012-05-30 |
| CA2767392C (en) | 2017-03-14 |
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