AU2009352490B2 - 1, 2-dihydro-2-oxoquinoline compounds as 5-HT 4 receptor ligands - Google Patents
1, 2-dihydro-2-oxoquinoline compounds as 5-HT 4 receptor ligands Download PDFInfo
- Publication number
- AU2009352490B2 AU2009352490B2 AU2009352490A AU2009352490A AU2009352490B2 AU 2009352490 B2 AU2009352490 B2 AU 2009352490B2 AU 2009352490 A AU2009352490 A AU 2009352490A AU 2009352490 A AU2009352490 A AU 2009352490A AU 2009352490 B2 AU2009352490 B2 AU 2009352490B2
- Authority
- AU
- Australia
- Prior art keywords
- hydroxy
- oxo
- compound
- carboxamide
- dihydroquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2224CH2009 | 2009-09-14 | ||
IN2224/CHE/2009 | 2009-09-14 | ||
PCT/IN2009/000745 WO2011030349A1 (en) | 2009-09-14 | 2009-12-29 | L -dihydro-2-oxoquinoline compounds a 5-ht4 receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2009352490A1 AU2009352490A1 (en) | 2012-04-19 |
AU2009352490B2 true AU2009352490B2 (en) | 2013-06-20 |
Family
ID=42126528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2009352490A Ceased AU2009352490B2 (en) | 2009-09-14 | 2009-12-29 | 1, 2-dihydro-2-oxoquinoline compounds as 5-HT 4 receptor ligands |
Country Status (17)
Country | Link |
---|---|
US (1) | US8598204B2 (ko) |
EP (1) | EP2507225B1 (ko) |
JP (1) | JP5540099B2 (ko) |
KR (1) | KR101386354B1 (ko) |
CN (1) | CN102639526B (ko) |
AU (1) | AU2009352490B2 (ko) |
CA (1) | CA2771885C (ko) |
DK (1) | DK2507225T3 (ko) |
EA (1) | EA020227B1 (ko) |
ES (1) | ES2578628T3 (ko) |
HK (1) | HK1173140A1 (ko) |
IL (1) | IL218525A (ko) |
MX (1) | MX2012002608A (ko) |
NZ (1) | NZ598505A (ko) |
SG (1) | SG178557A1 (ko) |
WO (1) | WO2011030349A1 (ko) |
ZA (1) | ZA201201429B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102405221B (zh) * | 2009-04-24 | 2015-01-21 | 日产化学工业株式会社 | 由二环氨基甲酸酯化合物制备2-氮杂金刚烷化合物的方法 |
RU2549551C2 (ru) * | 2009-06-19 | 2015-04-27 | Эббви Инк. | Производные диазагомоадамантана и способы их применения |
RU2672468C1 (ru) * | 2011-12-22 | 2018-11-15 | Конекшис Лайф Сайенсиз Пвт. Лтд. | Производные аза-адамантанов и их применение |
RU2557249C1 (ru) * | 2014-03-03 | 2015-07-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный технический университет" | Способ получения 1-гидрокси-4-адамантанона |
CN104447490B (zh) * | 2014-11-19 | 2017-06-06 | 连云港恒运医药有限公司 | 一种质子泵抑制剂的晶型、制备中间体及其合成方法和医药用途 |
IL297543A (en) | 2017-11-30 | 2022-12-01 | Arrakis Therapeutics Inc | Nucleic acid-binding photoprobes and their uses |
WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
CN115677567A (zh) * | 2022-11-15 | 2023-02-03 | 大唐环境产业集团股份有限公司 | 一种4-氨基-1-哌啶丙醇的合成方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060100236A1 (en) * | 2004-11-05 | 2006-05-11 | Theravance, Inc. | 5-HT4 receptor agonist compounds |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0664794A1 (en) | 1992-10-16 | 1995-08-02 | Smithkline Beecham Plc | N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists |
JPH07324087A (ja) * | 1994-04-04 | 1995-12-12 | Taisho Pharmaceut Co Ltd | 複素環化合物 |
US7405235B2 (en) * | 2001-05-04 | 2008-07-29 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
RU2404179C2 (ru) | 2004-12-22 | 2010-11-20 | Тереванс, Инк. | Индазол-карбоксамидные соединения |
ATE513827T1 (de) | 2005-02-22 | 2011-07-15 | Pfizer | Oxyindol-derivate als 5ht4-rezeptor-agonisten |
JP4970290B2 (ja) | 2005-02-25 | 2012-07-04 | ファイザー株式会社 | ベンズイソキサゾール誘導体 |
WO2006094063A1 (en) * | 2005-03-02 | 2006-09-08 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
ATE449092T1 (de) | 2005-07-22 | 2009-12-15 | Pfizer | Indazolcarbonsäureamidderivate als agonisten des 5ht4-rezeptors |
US8557994B2 (en) * | 2009-07-27 | 2013-10-15 | Daljit Singh Dhanoa | Deuterium-enriched pyridinonecarboxamides and derivatives |
-
2009
- 2009-12-29 JP JP2012528502A patent/JP5540099B2/ja not_active Expired - Fee Related
- 2009-12-29 ES ES09818647.1T patent/ES2578628T3/es active Active
- 2009-12-29 EA EA201270421A patent/EA020227B1/ru not_active IP Right Cessation
- 2009-12-29 MX MX2012002608A patent/MX2012002608A/es active IP Right Grant
- 2009-12-29 CN CN200980161395.0A patent/CN102639526B/zh not_active Expired - Fee Related
- 2009-12-29 KR KR1020127007464A patent/KR101386354B1/ko active IP Right Grant
- 2009-12-29 WO PCT/IN2009/000745 patent/WO2011030349A1/en active Application Filing
- 2009-12-29 NZ NZ598505A patent/NZ598505A/xx not_active IP Right Cessation
- 2009-12-29 DK DK09818647.1T patent/DK2507225T3/en active
- 2009-12-29 EP EP09818647.1A patent/EP2507225B1/en not_active Not-in-force
- 2009-12-29 AU AU2009352490A patent/AU2009352490B2/en not_active Ceased
- 2009-12-29 CA CA2771885A patent/CA2771885C/en not_active Expired - Fee Related
- 2009-12-29 SG SG2012013025A patent/SG178557A1/en unknown
- 2009-12-29 US US13/393,539 patent/US8598204B2/en not_active Expired - Fee Related
-
2012
- 2012-02-27 ZA ZA2012/01429A patent/ZA201201429B/en unknown
- 2012-03-07 IL IL218525A patent/IL218525A/en active IP Right Grant
-
2013
- 2013-01-07 HK HK13100187.8A patent/HK1173140A1/xx not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060100236A1 (en) * | 2004-11-05 | 2006-05-11 | Theravance, Inc. | 5-HT4 receptor agonist compounds |
Also Published As
Publication number | Publication date |
---|---|
ES2578628T3 (es) | 2016-07-28 |
AU2009352490A1 (en) | 2012-04-19 |
KR20120081986A (ko) | 2012-07-20 |
US20120277216A1 (en) | 2012-11-01 |
IL218525A (en) | 2014-12-31 |
JP2013504561A (ja) | 2013-02-07 |
JP5540099B2 (ja) | 2014-07-02 |
SG178557A1 (en) | 2012-03-29 |
MX2012002608A (es) | 2012-04-02 |
HK1173140A1 (en) | 2013-05-10 |
DK2507225T3 (en) | 2016-07-04 |
NZ598505A (en) | 2013-01-25 |
US8598204B2 (en) | 2013-12-03 |
EP2507225A1 (en) | 2012-10-10 |
CN102639526A (zh) | 2012-08-15 |
ZA201201429B (en) | 2012-10-31 |
WO2011030349A1 (en) | 2011-03-17 |
EP2507225B1 (en) | 2016-06-01 |
CA2771885A1 (en) | 2011-03-17 |
EA201270421A1 (ru) | 2012-09-28 |
EA020227B1 (ru) | 2014-09-30 |
CN102639526B (zh) | 2014-06-04 |
CA2771885C (en) | 2014-04-08 |
KR101386354B1 (ko) | 2014-04-16 |
IL218525A0 (en) | 2012-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ 1, 2-DIHYDRO-2-OXOQUINOLINE COMPOUNDS AS 5-HT 4 RECEPTOR LIGANDS |
|
FGA | Letters patent sealed or granted (standard patent) | ||
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |