AU2009332651A1 - Fused imidazole derivatives as TRPV3 antagonist - Google Patents

Fused imidazole derivatives as TRPV3 antagonist Download PDF

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Publication number
AU2009332651A1
AU2009332651A1 AU2009332651A AU2009332651A AU2009332651A1 AU 2009332651 A1 AU2009332651 A1 AU 2009332651A1 AU 2009332651 A AU2009332651 A AU 2009332651A AU 2009332651 A AU2009332651 A AU 2009332651A AU 2009332651 A1 AU2009332651 A1 AU 2009332651A1
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Australia
Prior art keywords
vinyl
methoxyphenyl
benzimidazol
nicotinonitrile
cyclopentyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2009332651A
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English (en)
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AU2009332651A2 (en
Inventor
Vidya Ganapati Kattige
Neelima Khairatkar-Joshi
Javed Yusuf Khatik
V. S. Prasadarao Lingam
Ajit Shankar Mindhe
Shantaram Kashinath Phatangare
Abraham Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ichnos Sciences SA
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Glenmark Pharmaceuticals SA
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Filing date
Publication date
Application filed by Glenmark Pharmaceuticals SA filed Critical Glenmark Pharmaceuticals SA
Publication of AU2009332651A1 publication Critical patent/AU2009332651A1/en
Publication of AU2009332651A2 publication Critical patent/AU2009332651A2/en
Abandoned legal-status Critical Current

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
AU2009332651A 2008-12-26 2009-12-23 Fused imidazole derivatives as TRPV3 antagonist Abandoned AU2009332651A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
IN2705/MUM/2008 2008-12-26
IN2705MU2008 2008-12-26
US14686509P 2009-01-23 2009-01-23
US61/146,865 2009-01-23
IN1732/MUM/2009 2009-07-29
IN1732MU2009 2009-07-29
US23743409P 2009-08-27 2009-08-27
US61/237,434 2009-08-27
PCT/IB2009/008018 WO2010073128A2 (en) 2008-12-26 2009-12-23 Fused imidazole derivatives as trpv3 antagonist

Publications (2)

Publication Number Publication Date
AU2009332651A1 true AU2009332651A1 (en) 2011-12-01
AU2009332651A2 AU2009332651A2 (en) 2012-05-03

Family

ID=42288192

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009332651A Abandoned AU2009332651A1 (en) 2008-12-26 2009-12-23 Fused imidazole derivatives as TRPV3 antagonist

Country Status (10)

Country Link
US (1) US8344010B2 (https=)
EP (1) EP2370425A4 (https=)
JP (1) JP2012514577A (https=)
AU (1) AU2009332651A1 (https=)
CA (1) CA2744911A1 (https=)
EA (1) EA201190086A1 (https=)
GE (1) GEP20146096B (https=)
MX (1) MX2011006821A (https=)
NZ (1) NZ595775A (https=)
WO (1) WO2010073128A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012651B2 (en) * 2011-03-24 2015-04-21 Abbvie Inc. TRPV3 modulators
CN107074846B (zh) 2014-08-12 2020-05-19 先正达参股股份有限公司 具有含硫取代基的杀有害生物活性杂环衍生物
WO2017001314A1 (en) 2015-07-01 2017-01-05 Syngenta Participations Ag Pesticidally active polycyclic derivatives with sulfur containing substituents
BR112018010347A2 (pt) 2015-11-23 2018-12-04 Syngenta Participations Ag derivados heterocíclicos ativos em termos pesticidas com substituintes contendo enxofre e ciclopropila
CN105503737B (zh) * 2016-01-25 2018-06-19 大连理工大学 一种无催化剂制备苯并咪唑类或苯并噻唑类化合物的方法
WO2017134066A1 (en) 2016-02-05 2017-08-10 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
CN109414430B (zh) * 2016-06-17 2022-11-01 药物递送解决方案私人有限责任公司 用于治疗尿毒性瘙痒症的制剂
AR118243A1 (es) 2019-03-07 2021-09-22 Pi Industries Ltd Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas
US12612369B1 (en) 2025-12-15 2026-04-28 King Faisal University Eco-friendly synthesis of a novel nicotinonitrile derivative (MNPN) with antibacterial and anti-inflammatory activities for preventing pressure ulcers in individuals with disabilities

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
JPS625966A (ja) * 1985-07-03 1987-01-12 Nippon Shinyaku Co Ltd ベンズイミダゾ−ル誘導体
US20040009537A1 (en) 2002-01-11 2004-01-15 Jack Roos Methods of modulating and of identifying agents that modulate intracellular calcium
JP4448170B2 (ja) 2004-08-18 2010-04-07 ベッチャー・ローベルト エノサル歯科インプラント
AU2005316739A1 (en) 2004-12-13 2006-06-22 Galileo Pharmaceuticals, Inc. Spiro derivatives as lipoxygenase inhibitors
JP2009511465A (ja) 2005-10-07 2009-03-19 グレンマーク・ファーマシューティカルズ・エスエー 置換ベンゾ縮合誘導体およびバニロイド受容体リガンドとしてのその使用
US7893260B2 (en) 2005-11-04 2011-02-22 Hydra Biosciences, Inc. Substituted quinazolin-4-one compounds for antagonizing TRPV3 function
WO2007059608A1 (en) * 2005-11-23 2007-05-31 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US7998980B2 (en) 2006-09-15 2011-08-16 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
WO2008140750A1 (en) 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
WO2009084034A2 (en) 2007-12-18 2009-07-09 Glenmark Pharmaceuticals, S. A. Chromane derivatives as trpv3 modulators
CA2724008A1 (en) * 2008-01-11 2009-09-11 Glenmark Pharmaceuticals, S.A. Fused pyrimidine derivatives as trpv3 modulators
US8119647B2 (en) 2008-04-23 2012-02-21 Glenmark Pharmaceuticals S.A. Fused pyrimidineone compounds as TRPV3 modulators
US8318928B2 (en) * 2008-12-15 2012-11-27 Glenmark Pharmaceuticals, S.A. Fused imidazole carboxamides as TRPV3 modulators

Also Published As

Publication number Publication date
WO2010073128A3 (en) 2012-06-07
NZ595775A (en) 2013-07-26
GEP20146096B (en) 2014-05-27
WO2010073128A2 (en) 2010-07-01
JP2012514577A (ja) 2012-06-28
EP2370425A2 (en) 2011-10-05
CA2744911A1 (en) 2010-07-01
EP2370425A4 (en) 2013-02-27
AU2009332651A2 (en) 2012-05-03
US8344010B2 (en) 2013-01-01
MX2011006821A (es) 2012-01-03
US20110257193A1 (en) 2011-10-20
EA201190086A1 (ru) 2012-06-29

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