NZ595775A - Fused imidazole derivatives as trpv3 antagonist - Google Patents
Fused imidazole derivatives as trpv3 antagonistInfo
- Publication number
- NZ595775A NZ595775A NZ595775A NZ59577509A NZ595775A NZ 595775 A NZ595775 A NZ 595775A NZ 595775 A NZ595775 A NZ 595775A NZ 59577509 A NZ59577509 A NZ 59577509A NZ 595775 A NZ595775 A NZ 595775A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pain
- disease
- vinyl
- nicotinonitrile
- imidazo
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 208000002193 Pain Diseases 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 208000004296 neuralgia Diseases 0.000 abstract 2
- IQTVYDHNLZSCPM-ACCUITESSA-N 6-[2-[(e)-2-(2-butoxy-3-methoxyphenyl)ethenyl]imidazo[4,5-b]pyridin-3-yl]pyridine-3-carbonitrile Chemical compound CCCCOC1=C(OC)C=CC=C1\C=C\C1=NC2=CC=CN=C2N1C1=CC=C(C#N)C=N1 IQTVYDHNLZSCPM-ACCUITESSA-N 0.000 abstract 1
- CSASCNRGJLQZED-ZRDIBKRKSA-N 6-[2-[(e)-2-(2-cyclopentyloxy-3-methoxyphenyl)ethenyl]imidazo[4,5-c]pyridin-1-yl]pyridine-3-carbonitrile Chemical compound C1CCCC1OC=1C(OC)=CC=CC=1\C=C\C1=NC2=CN=CC=C2N1C1=CC=C(C#N)C=N1 CSASCNRGJLQZED-ZRDIBKRKSA-N 0.000 abstract 1
- LBLALBKZCIQGMR-WYMLVPIESA-N 6-[2-[(e)-2-(3-methoxy-2-pentoxyphenyl)ethenyl]imidazo[4,5-b]pyridin-3-yl]pyridine-3-carbonitrile Chemical compound CCCCCOC1=C(OC)C=CC=C1\C=C\C1=NC2=CC=CN=C2N1C1=CC=C(C#N)C=N1 LBLALBKZCIQGMR-WYMLVPIESA-N 0.000 abstract 1
- GBWLVWNMNBZKPW-ACCUITESSA-N 6-[2-[(e)-2-[2-cyclopentyloxy-3-(difluoromethoxy)phenyl]ethenyl]imidazo[4,5-b]pyridin-3-yl]pyridine-3-carbonitrile Chemical compound C1CCCC1OC=1C(OC(F)F)=CC=CC=1\C=C\C1=NC2=CC=CN=C2N1C1=CC=C(C#N)C=N1 GBWLVWNMNBZKPW-ACCUITESSA-N 0.000 abstract 1
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006820 Arthralgia Diseases 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 206010058019 Cancer Pain Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000015943 Coeliac disease Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 208000012661 Dyskinesia Diseases 0.000 abstract 1
- 208000004232 Enteritis Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010020559 Hyperacusis Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000027530 Meniere disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 208000028389 Nerve injury Diseases 0.000 abstract 1
- 208000001294 Nociceptive Pain Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 208000004550 Postoperative Pain Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 208000009205 Tinnitus Diseases 0.000 abstract 1
- 206010060875 Uraemic pruritus Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 208000003728 Vulvodynia Diseases 0.000 abstract 1
- 206010069055 Vulvovaginal pain Diseases 0.000 abstract 1
- 208000009621 actinic keratosis Diseases 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000003925 brain function Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 208000009326 ileitis Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 230000008764 nerve damage Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
- 208000037916 non-allergic rhinitis Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001823 pruritic effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 231100000886 tinnitus Toxicity 0.000 abstract 1
- 230000001052 transient effect Effects 0.000 abstract 1
- 206010044652 trigeminal neuralgia Diseases 0.000 abstract 1
- 210000003932 urinary bladder Anatomy 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2705MU2008 | 2008-12-26 | ||
| US14686509P | 2009-01-23 | 2009-01-23 | |
| IN1732MU2009 | 2009-07-29 | ||
| US23743409P | 2009-08-27 | 2009-08-27 | |
| PCT/IB2009/008018 WO2010073128A2 (en) | 2008-12-26 | 2009-12-23 | Fused imidazole derivatives as trpv3 antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ595775A true NZ595775A (en) | 2013-07-26 |
Family
ID=42288192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ595775A NZ595775A (en) | 2008-12-26 | 2009-12-23 | Fused imidazole derivatives as trpv3 antagonist |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8344010B2 (https=) |
| EP (1) | EP2370425A4 (https=) |
| JP (1) | JP2012514577A (https=) |
| AU (1) | AU2009332651A1 (https=) |
| CA (1) | CA2744911A1 (https=) |
| EA (1) | EA201190086A1 (https=) |
| GE (1) | GEP20146096B (https=) |
| MX (1) | MX2011006821A (https=) |
| NZ (1) | NZ595775A (https=) |
| WO (1) | WO2010073128A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012651B2 (en) * | 2011-03-24 | 2015-04-21 | Abbvie Inc. | TRPV3 modulators |
| CN107074846B (zh) | 2014-08-12 | 2020-05-19 | 先正达参股股份有限公司 | 具有含硫取代基的杀有害生物活性杂环衍生物 |
| WO2017001314A1 (en) | 2015-07-01 | 2017-01-05 | Syngenta Participations Ag | Pesticidally active polycyclic derivatives with sulfur containing substituents |
| BR112018010347A2 (pt) | 2015-11-23 | 2018-12-04 | Syngenta Participations Ag | derivados heterocíclicos ativos em termos pesticidas com substituintes contendo enxofre e ciclopropila |
| CN105503737B (zh) * | 2016-01-25 | 2018-06-19 | 大连理工大学 | 一种无催化剂制备苯并咪唑类或苯并噻唑类化合物的方法 |
| WO2017134066A1 (en) | 2016-02-05 | 2017-08-10 | Syngenta Participations Ag | Pesticidally active heterocyclic derivatives with sulphur containing substituents |
| CN109414430B (zh) * | 2016-06-17 | 2022-11-01 | 药物递送解决方案私人有限责任公司 | 用于治疗尿毒性瘙痒症的制剂 |
| AR118243A1 (es) | 2019-03-07 | 2021-09-22 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| US12612369B1 (en) | 2025-12-15 | 2026-04-28 | King Faisal University | Eco-friendly synthesis of a novel nicotinonitrile derivative (MNPN) with antibacterial and anti-inflammatory activities for preventing pressure ulcers in individuals with disabilities |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS625966A (ja) * | 1985-07-03 | 1987-01-12 | Nippon Shinyaku Co Ltd | ベンズイミダゾ−ル誘導体 |
| US20040009537A1 (en) | 2002-01-11 | 2004-01-15 | Jack Roos | Methods of modulating and of identifying agents that modulate intracellular calcium |
| JP4448170B2 (ja) | 2004-08-18 | 2010-04-07 | ベッチャー・ローベルト | エノサル歯科インプラント |
| AU2005316739A1 (en) | 2004-12-13 | 2006-06-22 | Galileo Pharmaceuticals, Inc. | Spiro derivatives as lipoxygenase inhibitors |
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| US7893260B2 (en) | 2005-11-04 | 2011-02-22 | Hydra Biosciences, Inc. | Substituted quinazolin-4-one compounds for antagonizing TRPV3 function |
| WO2007059608A1 (en) * | 2005-11-23 | 2007-05-31 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| US7998980B2 (en) | 2006-09-15 | 2011-08-16 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 function |
| WO2008140750A1 (en) | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| WO2009084034A2 (en) | 2007-12-18 | 2009-07-09 | Glenmark Pharmaceuticals, S. A. | Chromane derivatives as trpv3 modulators |
| CA2724008A1 (en) * | 2008-01-11 | 2009-09-11 | Glenmark Pharmaceuticals, S.A. | Fused pyrimidine derivatives as trpv3 modulators |
| US8119647B2 (en) | 2008-04-23 | 2012-02-21 | Glenmark Pharmaceuticals S.A. | Fused pyrimidineone compounds as TRPV3 modulators |
| US8318928B2 (en) * | 2008-12-15 | 2012-11-27 | Glenmark Pharmaceuticals, S.A. | Fused imidazole carboxamides as TRPV3 modulators |
-
2009
- 2009-12-23 JP JP2011542926A patent/JP2012514577A/ja active Pending
- 2009-12-23 AU AU2009332651A patent/AU2009332651A1/en not_active Abandoned
- 2009-12-23 MX MX2011006821A patent/MX2011006821A/es active IP Right Grant
- 2009-12-23 US US13/141,199 patent/US8344010B2/en not_active Expired - Fee Related
- 2009-12-23 GE GEAP200912274A patent/GEP20146096B/en unknown
- 2009-12-23 WO PCT/IB2009/008018 patent/WO2010073128A2/en not_active Ceased
- 2009-12-23 EP EP09834200A patent/EP2370425A4/en not_active Withdrawn
- 2009-12-23 CA CA2744911A patent/CA2744911A1/en not_active Abandoned
- 2009-12-23 NZ NZ595775A patent/NZ595775A/xx not_active IP Right Cessation
- 2009-12-23 EA EA201190086A patent/EA201190086A1/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010073128A3 (en) | 2012-06-07 |
| GEP20146096B (en) | 2014-05-27 |
| WO2010073128A2 (en) | 2010-07-01 |
| JP2012514577A (ja) | 2012-06-28 |
| EP2370425A2 (en) | 2011-10-05 |
| CA2744911A1 (en) | 2010-07-01 |
| EP2370425A4 (en) | 2013-02-27 |
| AU2009332651A2 (en) | 2012-05-03 |
| US8344010B2 (en) | 2013-01-01 |
| MX2011006821A (es) | 2012-01-03 |
| US20110257193A1 (en) | 2011-10-20 |
| AU2009332651A1 (en) | 2011-12-01 |
| EA201190086A1 (ru) | 2012-06-29 |
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