AU2009307841B2 - Fibroblast growth factor receptor-3 (FGFR-3) inhibitors and methods of treatment - Google Patents
Fibroblast growth factor receptor-3 (FGFR-3) inhibitors and methods of treatment Download PDFInfo
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- AU2009307841B2 AU2009307841B2 AU2009307841A AU2009307841A AU2009307841B2 AU 2009307841 B2 AU2009307841 B2 AU 2009307841B2 AU 2009307841 A AU2009307841 A AU 2009307841A AU 2009307841 A AU2009307841 A AU 2009307841A AU 2009307841 B2 AU2009307841 B2 AU 2009307841B2
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- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19685508P | 2008-10-20 | 2008-10-20 | |
| US61/196,855 | 2008-10-20 | ||
| PCT/US2009/060840 WO2010048026A2 (en) | 2008-10-20 | 2009-10-15 | Fibroblast growth factor receptor-3 (fgfr-3) inhibitors and methods of treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009307841A1 AU2009307841A1 (en) | 2010-04-29 |
| AU2009307841B2 true AU2009307841B2 (en) | 2013-09-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009307841A Ceased AU2009307841B2 (en) | 2008-10-20 | 2009-10-15 | Fibroblast growth factor receptor-3 (FGFR-3) inhibitors and methods of treatment |
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| EP (1) | EP2342232A2 (enExample) |
| JP (1) | JP5577345B2 (enExample) |
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| CN (2) | CN102186884B (enExample) |
| AR (1) | AR073770A1 (enExample) |
| AU (1) | AU2009307841B2 (enExample) |
| BR (1) | BRPI0919832A8 (enExample) |
| CA (1) | CA2741127C (enExample) |
| EA (1) | EA021584B1 (enExample) |
| IL (1) | IL211807A0 (enExample) |
| MX (1) | MX2011004317A (enExample) |
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| TW (1) | TWI381848B (enExample) |
| UA (1) | UA101681C2 (enExample) |
| WO (1) | WO2010048026A2 (enExample) |
| ZA (1) | ZA201101938B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR073770A1 (es) | 2008-10-20 | 2010-12-01 | Imclone Llc | Anticuerpo aislado que se enlaza especificamente con, e induce la degradacion del receptor-3 del factor de crecimiento del fibroblasto humano (fgfr-3), fragmento de enlace fgfr-3 humano del mismo, composicion farmaceutica y producto que lo comprenden |
| DK3702371T5 (da) | 2009-03-25 | 2024-08-26 | Genentech Inc | Anti-FGFR3-antistoffer og fremgangsmåder ved anvendelse af disse |
| WO2013088191A1 (en) | 2011-12-12 | 2013-06-20 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antagonist of the fibroblast growth factor receptor 3 (fgfr3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of fgfr3 |
| WO2014111744A1 (en) | 2013-01-16 | 2014-07-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A soluble fibroblast growth factor receptor 3 (fgr3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders |
| MX2015011428A (es) | 2013-03-06 | 2016-02-03 | Genentech Inc | Metodos para tratar y prevenir la resistencia a los farmacos para el cancer. |
| TWI541022B (zh) | 2013-12-18 | 2016-07-11 | 應克隆公司 | 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法 |
| EP3122776B1 (en) | 2014-03-25 | 2021-04-28 | Regeneron Pharmaceuticals, Inc. | Fgf21 receptor agonists and uses thereof |
| EP3151857A4 (en) * | 2014-06-03 | 2018-04-18 | Merck Sharp & Dohme Corp. | Anti-blys antibodies |
| CN107073121A (zh) | 2014-06-13 | 2017-08-18 | 基因泰克公司 | 治疗及预防癌症药物抗性的方法 |
| MX384149B (es) * | 2014-09-05 | 2025-03-14 | Hyperfine Inc | Aumento ferromagnético para formación de imagenes por resonancia magnética. |
| KR102470456B1 (ko) | 2014-09-26 | 2022-11-23 | 얀센 파마슈티카 엔.브이. | Fgfr 억제제를 사용한 치료에 반응할 암 환자를 확인하는 데 있어서 fgfr 돌연변이 유전자 패널의 사용 |
| SG11201706727XA (en) * | 2015-02-19 | 2017-09-28 | Bioclin Therapeutics Inc | Methods, compositions, and kits for treatment of cancer |
| US20180237424A1 (en) | 2015-03-03 | 2018-08-23 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Fgfr3 antagonists |
| TW201711702A (zh) | 2015-06-04 | 2017-04-01 | 應克隆公司 | 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法 |
| WO2017100642A1 (en) | 2015-12-11 | 2017-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for reducing or preventing growth of tumors resistant to egfr and/or erbb3 blockade |
| MX2018016257A (es) | 2016-07-07 | 2019-11-21 | Therachon Sas | Polipéptidos del receptor 3 del factor de crecimiento de fibroblastos solubles (sfgfr3) y usos de los mismos. |
| US20180244785A1 (en) * | 2017-01-09 | 2018-08-30 | Merrimack Pharmaceuticals, Inc. | Anti-fgfr antibodies and methods of use |
| AR123306A1 (es) | 2020-08-21 | 2022-11-16 | Genzyme Corp | Anticuerpos fgfr3 y métodos de uso |
| CN114015770B (zh) * | 2021-12-30 | 2022-04-26 | 佛山市第三人民医院(佛山市精神卫生中心) | 精神分裂全外周血rna标志物fgfr3及其应用 |
| US20240173426A1 (en) * | 2022-11-14 | 2024-05-30 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes |
| IL322053A (en) | 2023-01-13 | 2025-09-01 | Regeneron Pharma | FGFR3 binding molecules and methods of using them |
| WO2025240335A1 (en) | 2024-05-13 | 2025-11-20 | Regeneron Pharmaceuticals, Inc. | Fgfr3 binding molecules and methods of use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102973A2 (en) * | 2001-06-20 | 2002-12-27 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| AU612370B2 (en) | 1987-05-21 | 1991-07-11 | Micromet Ag | Targeted multifunctional proteins |
| CA2550245A1 (en) | 2003-12-19 | 2005-07-21 | Five Prime Therapeutics, Inc. | Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention |
| MX2008014978A (es) * | 2006-06-06 | 2008-12-09 | Crucell Holland Bv | Moleculas de union humanas que tienen actividad exterminadora contra enterococos y staphylococcus aureus y usos de las mismas. |
| US8192927B2 (en) * | 2006-09-07 | 2012-06-05 | Crucell Holland B.V. | Human bind molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| ES2453592T3 (es) * | 2007-08-02 | 2014-04-08 | Novimmune Sa | Anticuerpos anti-RANTES y métodos de uso de los mismos |
| KR102057826B1 (ko) * | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| US8187601B2 (en) | 2008-07-01 | 2012-05-29 | Aveo Pharmaceuticals, Inc. | Fibroblast growth factor receptor 3 (FGFR3) binding proteins |
| AR073770A1 (es) * | 2008-10-20 | 2010-12-01 | Imclone Llc | Anticuerpo aislado que se enlaza especificamente con, e induce la degradacion del receptor-3 del factor de crecimiento del fibroblasto humano (fgfr-3), fragmento de enlace fgfr-3 humano del mismo, composicion farmaceutica y producto que lo comprenden |
-
2009
- 2009-10-05 AR ARP090103832A patent/AR073770A1/es unknown
- 2009-10-05 TW TW098133737A patent/TWI381848B/zh not_active IP Right Cessation
- 2009-10-15 CA CA2741127A patent/CA2741127C/en not_active Expired - Fee Related
- 2009-10-15 MX MX2011004317A patent/MX2011004317A/es active IP Right Grant
- 2009-10-15 WO PCT/US2009/060840 patent/WO2010048026A2/en not_active Ceased
- 2009-10-15 US US12/579,825 patent/US8043618B2/en not_active Expired - Fee Related
- 2009-10-15 AU AU2009307841A patent/AU2009307841B2/en not_active Ceased
- 2009-10-15 KR KR1020117008935A patent/KR101370798B1/ko not_active Expired - Fee Related
- 2009-10-15 EP EP09737319A patent/EP2342232A2/en not_active Ceased
- 2009-10-15 NZ NZ592369A patent/NZ592369A/xx not_active IP Right Cessation
- 2009-10-15 JP JP2011532250A patent/JP5577345B2/ja not_active Expired - Fee Related
- 2009-10-15 CN CN200980141656.2A patent/CN102186884B/zh not_active Expired - Fee Related
- 2009-10-15 CN CN201310384769.3A patent/CN103524620A/zh active Pending
- 2009-10-15 UA UAA201104814A patent/UA101681C2/ru unknown
- 2009-10-15 BR BRPI0919832A patent/BRPI0919832A8/pt not_active IP Right Cessation
- 2009-10-15 EA EA201170590A patent/EA021584B1/ru not_active IP Right Cessation
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2011
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2012
- 2012-04-20 US US13/452,043 patent/US8404240B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102973A2 (en) * | 2001-06-20 | 2002-12-27 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
Non-Patent Citations (2)
| Title |
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| Martinex-Torrecuadrada J., et al: Clin Cancer Res, 2005, vol 11, no 17, pp 6280-6290 * |
| Wang W., et al: Eur J Cancer, 2008, vol 6, no 12, pp 63 * |
Also Published As
| Publication number | Publication date |
|---|---|
| UA101681C2 (ru) | 2013-04-25 |
| KR20110056554A (ko) | 2011-05-30 |
| US20100098696A1 (en) | 2010-04-22 |
| EA021584B1 (ru) | 2015-07-30 |
| CA2741127C (en) | 2015-06-02 |
| BRPI0919832A8 (pt) | 2019-01-08 |
| CN103524620A (zh) | 2014-01-22 |
| CN102186884B (zh) | 2014-08-13 |
| US20120009200A1 (en) | 2012-01-12 |
| TWI381848B (zh) | 2013-01-11 |
| IL211807A0 (en) | 2011-06-30 |
| WO2010048026A3 (en) | 2010-07-15 |
| ZA201101938B (en) | 2012-08-29 |
| AR073770A1 (es) | 2010-12-01 |
| MX2011004317A (es) | 2011-06-24 |
| JP2012505912A (ja) | 2012-03-08 |
| EP2342232A2 (en) | 2011-07-13 |
| WO2010048026A2 (en) | 2010-04-29 |
| KR101370798B1 (ko) | 2014-03-14 |
| US8182815B2 (en) | 2012-05-22 |
| BRPI0919832A2 (pt) | 2015-12-15 |
| AU2009307841A1 (en) | 2010-04-29 |
| TW201026325A (en) | 2010-07-16 |
| CN102186884A (zh) | 2011-09-14 |
| US8043618B2 (en) | 2011-10-25 |
| US20120219563A1 (en) | 2012-08-30 |
| EA201170590A1 (ru) | 2011-10-31 |
| CA2741127A1 (en) | 2010-04-29 |
| US8404240B2 (en) | 2013-03-26 |
| NZ592369A (en) | 2013-02-22 |
| JP5577345B2 (ja) | 2014-08-20 |
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