AU2009306795B2 - Azaindole derivative - Google Patents
Azaindole derivative Download PDFInfo
- Publication number
- AU2009306795B2 AU2009306795B2 AU2009306795A AU2009306795A AU2009306795B2 AU 2009306795 B2 AU2009306795 B2 AU 2009306795B2 AU 2009306795 A AU2009306795 A AU 2009306795A AU 2009306795 A AU2009306795 A AU 2009306795A AU 2009306795 B2 AU2009306795 B2 AU 2009306795B2
- Authority
- AU
- Australia
- Prior art keywords
- tumour
- pct
- compounds
- pyrrolo
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 125000005334 azaindolyl group Chemical class N1N=C(C2=CC=CC=C12)* 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 131
- 150000003839 salts Chemical class 0.000 claims description 65
- 206010028980 Neoplasm Diseases 0.000 claims description 56
- 239000000203 mixture Substances 0.000 claims description 55
- 238000011282 treatment Methods 0.000 claims description 43
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- 201000010099 disease Diseases 0.000 claims description 39
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- 238000000034 method Methods 0.000 claims description 30
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- 238000002360 preparation method Methods 0.000 claims description 20
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- 208000022873 Ocular disease Diseases 0.000 claims description 8
- 201000004681 Psoriasis Diseases 0.000 claims description 8
- 230000015572 biosynthetic process Effects 0.000 claims description 8
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- 210000000987 immune system Anatomy 0.000 claims description 7
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- 206010003210 Arteriosclerosis Diseases 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 5
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
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- Transplantation (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008052943.5 | 2008-10-23 | ||
| DE102008052943A DE102008052943A1 (de) | 2008-10-23 | 2008-10-23 | Azaindolderivate |
| PCT/EP2009/006911 WO2010046013A1 (de) | 2008-10-23 | 2009-09-24 | Azaindolderivate |
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| AU2009306795A1 AU2009306795A1 (en) | 2010-04-29 |
| AU2009306795B2 true AU2009306795B2 (en) | 2015-07-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| WO2011075613A1 (en) * | 2009-12-18 | 2011-06-23 | Sanofi | Azaindole derivatives, their preparation and their therapeutic application |
| DE102010050558A1 (de) * | 2010-11-05 | 2012-05-10 | Merck Patent Gmbh | 1H-Pyrrolo[2,3-b]pyridinderivate |
| CA2834049C (en) | 2011-04-25 | 2018-05-22 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| EA031618B1 (ru) * | 2011-06-09 | 2019-01-31 | Ризен Фармасьютикалз Са | Соединения-модуляторы gpr-119 |
| GB201217285D0 (en) * | 2012-09-27 | 2012-11-14 | Univ Central Lancashire | Indole derivatives |
| US9227976B2 (en) | 2012-10-25 | 2016-01-05 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| JP6320506B2 (ja) * | 2013-03-12 | 2018-05-09 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
| KR20160104729A (ko) * | 2014-01-24 | 2016-09-05 | 컨플루언스 라이프 사이언시스, 인코포레이티드 | 암 또는 염증성 질환의 치료를 위한 치환 피롤로피리딘 및 피롤로피라진 |
| TN2016000501A1 (en) | 2014-05-15 | 2018-04-04 | Iteos Therapeutics | Pyrrolidine-2,5-dione derivatives, pharmaceutical compositions and methods for use as ido1 inhibitors. |
| TW201630907A (zh) * | 2014-12-22 | 2016-09-01 | 必治妥美雅史谷比公司 | ＴＧＦβＲ拮抗劑 |
| EP3247353A4 (en) | 2015-01-23 | 2018-07-04 | Confluence Life Sciences, Inc. | Heterocyclic itk inhibitors for treating inflammation and cancer |
| JP6775516B2 (ja) | 2015-03-17 | 2020-10-28 | ファイザー・インク | 新奇な３−インドール置換誘導体、医薬組成物、および使用方法 |
| JP2018527336A (ja) | 2015-08-10 | 2018-09-20 | ファイザー・インク | ３−インドール置換誘導体、医薬組成物、および使用方法 |
| JP2019512474A (ja) * | 2016-03-01 | 2019-05-16 | ノバルティス アーゲー | シアノ置換インドール化合物およびｌｓｄ１阻害剤としてのその使用 |
| JP7030066B2 (ja) * | 2016-05-26 | 2022-03-04 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | Ｅｇｆｒ阻害剤化合物 |
| EP3523290A4 (en) * | 2016-09-30 | 2020-07-29 | Novartis AG | IMPROVED EFFICIENCY IMMUNE EFFICIENT CELL THERAPIES |
| WO2018210658A1 (en) | 2017-05-15 | 2018-11-22 | Basf Se | Heteroaryl compounds as agrochemical fungicides |
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| WO2019057660A1 (en) | 2017-09-25 | 2019-03-28 | Basf Se | INDOLE AND AZAINDOLE COMPOUNDS HAVING 6-CHANNEL SUBSTITUTED ARYL AND HETEROARYL CYCLES AS AGROCHEMICAL FUNGICIDES |
| EP3730489A1 (en) | 2019-04-25 | 2020-10-28 | Basf Se | Heteroaryl compounds as agrochemical fungicides |
| KR102513463B1 (ko) * | 2020-11-26 | 2023-03-29 | 주식회사 에스앤케이테라퓨틱스 | 엔도솜 톨-유사 수용체를 제어하는 신규 소분자 화합물 및 이를 이용한 자가면역질환 치료제 |
| CN116332940B (zh) * | 2023-02-14 | 2024-09-13 | 广西民族大学 | 一种7-脱氮嘌呤衍生物及其制备方法和应用 |
| WO2024245193A1 (zh) * | 2023-05-26 | 2024-12-05 | 上海艾力斯医药科技股份有限公司 | 杂芳环类化合物、其药物组合物及其应用 |
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Also Published As
| Publication number | Publication date |
|---|---|
| DE102008052943A1 (de) | 2010-04-29 |
| CA2741428A1 (en) | 2010-04-29 |
| US20110207732A1 (en) | 2011-08-25 |
| EP2342202A1 (de) | 2011-07-13 |
| JP5662325B2 (ja) | 2015-01-28 |
| IL212285A0 (en) | 2011-06-30 |
| ES2559427T3 (es) | 2016-02-12 |
| AU2009306795A1 (en) | 2010-04-29 |
| EP2342202B1 (de) | 2015-11-11 |
| WO2010046013A1 (de) | 2010-04-29 |
| JP2012506389A (ja) | 2012-03-15 |
| CA2741428C (en) | 2017-05-09 |
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