AU2009260899B2 - Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders - Google Patents
Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders Download PDFInfo
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- AU2009260899B2 AU2009260899B2 AU2009260899A AU2009260899A AU2009260899B2 AU 2009260899 B2 AU2009260899 B2 AU 2009260899B2 AU 2009260899 A AU2009260899 A AU 2009260899A AU 2009260899 A AU2009260899 A AU 2009260899A AU 2009260899 B2 AU2009260899 B2 AU 2009260899B2
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- Prior art keywords
- phenethoxy
- compound
- ethyl
- propanamide
- mixture
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7342008P | 2008-06-18 | 2008-06-18 | |
| US61/073,420 | 2008-06-18 | ||
| PCT/SE2009/050749 WO2009154557A1 (en) | 2008-06-18 | 2009-06-17 | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
Publications (2)
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| AU2009260899A1 AU2009260899A1 (en) | 2009-12-23 |
| AU2009260899B2 true AU2009260899B2 (en) | 2012-02-23 |
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| AU2009260899A Ceased AU2009260899B2 (en) | 2008-06-18 | 2009-06-17 | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
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| EP (1) | EP2303873A4 (OSRAM) |
| JP (1) | JP2011524896A (OSRAM) |
| KR (1) | KR20110017456A (OSRAM) |
| CN (1) | CN102124003A (OSRAM) |
| AR (1) | AR072189A1 (OSRAM) |
| AU (1) | AU2009260899B2 (OSRAM) |
| BR (1) | BRPI0915428A2 (OSRAM) |
| CA (1) | CA2726746A1 (OSRAM) |
| CL (1) | CL2010001459A1 (OSRAM) |
| CO (1) | CO6321269A2 (OSRAM) |
| CR (1) | CR11856A (OSRAM) |
| DO (1) | DOP2010000389A (OSRAM) |
| EA (1) | EA201001747A1 (OSRAM) |
| EC (1) | ECSP10010694A (OSRAM) |
| IL (1) | IL209731A0 (OSRAM) |
| MX (1) | MX2010013477A (OSRAM) |
| TW (1) | TW201002696A (OSRAM) |
| UY (1) | UY31905A (OSRAM) |
| WO (1) | WO2009154557A1 (OSRAM) |
| ZA (1) | ZA201008886B (OSRAM) |
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| UY31905A (es) | 2008-06-18 | 2010-01-29 | Astrazeneca Ab | Derivados de benzoxazinona, procesos de preparación, composiciones farmacéuticas conteniéndolos y aplicaciones. |
| WO2011048409A1 (en) | 2009-10-20 | 2011-04-28 | Astrazeneca Ab | Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| WO2011073662A1 (en) | 2009-12-17 | 2011-06-23 | Astrazeneca Ab | Combination of a benzoxazinone and a further agent for treating respiratory diseases |
| CN102993116A (zh) * | 2012-12-04 | 2013-03-27 | 常州大学 | 一种苯并噁嗪类激动剂的制备方法 |
| ES2707726T3 (es) * | 2014-06-30 | 2019-04-04 | Astrazeneca Ab | Amidas de benzoxazinona como moduladores del receptor de mineralocorticoides |
| CN104496920A (zh) * | 2014-12-04 | 2015-04-08 | 北京理工大学 | 一种n-烯丙基-二取代四唑及其制备方法和检测方法 |
| CN107188865B (zh) * | 2016-03-14 | 2019-08-27 | 益方生物科技（上海）有限公司 | 苯并噁嗪化合物及其制备方法和用途 |
| PL424609A1 (pl) * | 2018-02-16 | 2019-08-26 | Uniwersytet Przyrodniczy we Wrocławiu | Zastosowanie 6-(tert-butylo)-3-dodecylo-3,4-dihydro-2H-benzo[e][1,3]oxazyny |
| CN110028521B (zh) * | 2019-05-27 | 2020-07-14 | 湖南科技大学 | 11-芳基-1,4-苯并恶嗪酮并咪唑啉类化合物及其制备方法和用途 |
| EP4194453A1 (en) | 2021-12-08 | 2023-06-14 | Basf Se | Pyrazine compounds for the control of invertebrate pests |
| WO2023104564A1 (en) | 2021-12-08 | 2023-06-15 | Basf Se | Pyrazine compounds for the control of invertebrate pests |
| CN117143019B (zh) * | 2023-07-28 | 2025-11-25 | 常州大学 | 用作β2-肾上腺素受体别构拮抗剂的吡唑酰胺类衍生物 |
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| AU581887B2 (en) | 1984-04-17 | 1989-03-09 | Glaxo Group Limited | Ethanolamine compounds |
| US4554287A (en) | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones |
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| JP4176148B2 (ja) | 1996-05-20 | 2008-11-05 | 帝人ファーマ株式会社 | ジアリールアルキル環状ジアミン誘導体およびその治療薬としての使用 |
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| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
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| US6506901B2 (en) | 2000-07-17 | 2003-01-14 | Wyeth | Substituted 2-(S)-hydroxy-3-(piperidin-4-yl-methylamino)-propyl ethers and substituted 2-aryl-2-(R)-hydroxy-1-(piperidin-4-yl-methyl)-ethylamine β-3 adrenergic receptor agonists |
| WO2002076933A1 (en) | 2001-03-22 | 2002-10-03 | Glaxo Group Limited | Formailide derivatives as beta2-adrenoreceptor agonists |
| BRPI0212455B8 (pt) | 2001-09-14 | 2021-05-25 | Glaxo Group Ltd | composto derivado de fenetanolamina para o tratamento de doenças respiratórias, formulação farmacêutica, combinação, e, uso do mesmo |
| US20030229058A1 (en) | 2001-11-13 | 2003-12-11 | Moran Edmund J. | Aryl aniline beta2 adrenergic receptor agonists |
| GB0217225D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicinal compounds |
| AR040962A1 (es) | 2002-08-09 | 2005-04-27 | Novartis Ag | Compuestos derivados de tiazol 1,3-2-ona, composicion farmaceutica y proceso de preparacion del compuesto |
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| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
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| TW200526547A (en) | 2003-09-22 | 2005-08-16 | Theravance Inc | Amino-substituted ethylamino β2 adrenergic receptor agonists |
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2009
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- 2009-06-17 BR BRPI0915428A patent/BRPI0915428A2/pt not_active IP Right Cessation
- 2009-06-17 JP JP2011514537A patent/JP2011524896A/ja active Pending
- 2009-06-17 AU AU2009260899A patent/AU2009260899B2/en not_active Ceased
- 2009-06-17 KR KR1020117001144A patent/KR20110017456A/ko not_active Withdrawn
- 2009-06-17 MX MX2010013477A patent/MX2010013477A/es active IP Right Grant
- 2009-06-17 WO PCT/SE2009/050749 patent/WO2009154557A1/en not_active Ceased
- 2009-06-17 EA EA201001747A patent/EA201001747A1/ru unknown
- 2009-06-17 EP EP09766947A patent/EP2303873A4/en not_active Withdrawn
- 2009-06-17 TW TW098120291A patent/TW201002696A/zh unknown
- 2009-06-17 CA CA2726746A patent/CA2726746A1/en not_active Abandoned
- 2009-06-17 CN CN2009801320729A patent/CN102124003A/zh active Pending
- 2009-06-18 US US12/486,854 patent/US8017602B2/en not_active Expired - Fee Related
- 2009-06-18 AR ARP090102225A patent/AR072189A1/es unknown
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- 2010-12-02 IL IL209731A patent/IL209731A0/en unknown
- 2010-12-09 ZA ZA2010/08886A patent/ZA201008886B/en unknown
- 2010-12-17 CL CL2010001459A patent/CL2010001459A1/es unknown
- 2010-12-17 DO DO2010000389A patent/DOP2010000389A/es unknown
- 2010-12-17 EC EC2010010694A patent/ECSP10010694A/es unknown
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Also Published As
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|---|---|
| US20100105642A1 (en) | 2010-04-29 |
| CA2726746A1 (en) | 2009-12-23 |
| KR20110017456A (ko) | 2011-02-21 |
| EP2303873A1 (en) | 2011-04-06 |
| ECSP10010694A (es) | 2011-01-31 |
| CL2010001459A1 (es) | 2011-09-23 |
| CR11856A (es) | 2011-02-25 |
| EP2303873A4 (en) | 2012-01-04 |
| JP2011524896A (ja) | 2011-09-08 |
| US8017602B2 (en) | 2011-09-13 |
| TW201002696A (en) | 2010-01-16 |
| MX2010013477A (es) | 2010-12-21 |
| ZA201008886B (en) | 2011-08-31 |
| CO6321269A2 (es) | 2011-09-20 |
| AU2009260899A1 (en) | 2009-12-23 |
| CN102124003A (zh) | 2011-07-13 |
| IL209731A0 (en) | 2011-02-28 |
| UY31905A (es) | 2010-01-29 |
| AR072189A1 (es) | 2010-08-11 |
| DOP2010000389A (es) | 2011-01-15 |
| WO2009154557A1 (en) | 2009-12-23 |
| BRPI0915428A2 (pt) | 2015-11-03 |
| EA201001747A1 (ru) | 2011-08-30 |
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