AU2009256237B2 - 6-substituted estradiol derivatives and methods of use - Google Patents
6-substituted estradiol derivatives and methods of use Download PDFInfo
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- AU2009256237B2 AU2009256237B2 AU2009256237A AU2009256237A AU2009256237B2 AU 2009256237 B2 AU2009256237 B2 AU 2009256237B2 AU 2009256237 A AU2009256237 A AU 2009256237A AU 2009256237 A AU2009256237 A AU 2009256237A AU 2009256237 B2 AU2009256237 B2 AU 2009256237B2
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- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
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- 230000000365 steroidogenetic effect Effects 0.000 description 1
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- 238000007920 subcutaneous administration Methods 0.000 description 1
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- 150000003890 succinate salts Chemical class 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
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- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 229910001936 tantalum oxide Inorganic materials 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C12N2501/392—Sexual steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/132,857 US8168621B2 (en) | 2005-09-30 | 2008-06-04 | 6-substituted estradiol derivatives and methods of use |
| US12/132,857 | 2008-06-04 | ||
| PCT/US2009/046120 WO2009149176A1 (en) | 2008-06-04 | 2009-06-03 | 6-substituted estradiol derivatives and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009256237A1 AU2009256237A1 (en) | 2009-12-10 |
| AU2009256237B2 true AU2009256237B2 (en) | 2015-11-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009256237A Ceased AU2009256237B2 (en) | 2008-06-04 | 2009-06-03 | 6-substituted estradiol derivatives and methods of use |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8168621B2 (enExample) |
| EP (1) | EP2300016B1 (enExample) |
| JP (1) | JP5727370B2 (enExample) |
| KR (1) | KR101769152B1 (enExample) |
| CN (1) | CN102076343B (enExample) |
| AU (1) | AU2009256237B2 (enExample) |
| BR (1) | BRPI0913632A2 (enExample) |
| CA (1) | CA2726364C (enExample) |
| DK (1) | DK2300016T3 (enExample) |
| ES (1) | ES2641779T3 (enExample) |
| MX (1) | MX2010013288A (enExample) |
| NO (1) | NO2300016T3 (enExample) |
| WO (1) | WO2009149176A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1392313E (pt) * | 2001-05-16 | 2007-07-17 | Novartis Ag | Combinação que compreende n - ( 5- [ 4- ( metil-piperazinomrtil ) - benxoilamido ] - 2 -metilfenil ) - 4 -( 3 - piridil ) - 2 - pirimidina-amina e um agente quimioterapêutico |
| US10174070B2 (en) * | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
| US20090028895A1 (en) * | 2007-07-27 | 2009-01-29 | Smith Walter P | Methods and compositions for reducing facial lines and wrinkles |
| BR112013005843A2 (pt) * | 2010-09-14 | 2019-12-10 | Endece Llc | derivativos de er-beta 6-substituído por desmetil-estradiol |
| MX354409B (es) * | 2011-03-21 | 2018-03-05 | Endece Llc | Derivados de estradiol sustituidos en 6 para uso en remielinización de axones nerviosos. |
| US11624095B2 (en) | 2017-09-27 | 2023-04-11 | Case Western Reserve University | Method of quantifying HIV reservoirs by induced transcription based sequencing |
| US20210024568A1 (en) * | 2019-07-23 | 2021-01-28 | Endece Llc | Methods for modulation of lipoprotein lipase and apolipoprotein c2 expression and/or activity in the treatment of peripheral and central nervous system tissue disease states |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4840943A (en) * | 1986-06-20 | 1989-06-20 | Farmitalia Carlo Ebra S.R.L. | Androst-4-ene-3,17-diones and process for their preparation |
| US6239123B1 (en) * | 1998-08-11 | 2001-05-29 | Entremed, Inc. | Use of estrogenic compounds as anti-fungal agents |
| US20080119447A1 (en) * | 2005-09-30 | 2008-05-22 | James Yarger | 6-alkoxyalkyl estradiol derivatives and methods of use |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL122154C (enExample) | 1963-10-18 | |||
| GB8517360D0 (en) | 1985-07-09 | 1985-08-14 | Erba Farmitalia | Substituted androsta-1,4-diene-3,17-diones |
| GB8801697D0 (en) | 1988-01-26 | 1988-02-24 | Erba Farmitalia | Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione |
| US4904950A (en) | 1988-11-04 | 1990-02-27 | Medical Data Electronics, Inc. | Telemetry digital subcarrier demodulator |
| US5504074A (en) * | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
| JPH07215992A (ja) | 1993-12-07 | 1995-08-15 | Teikoku Hormone Mfg Co Ltd | ６−又は７−置換アンドロスタ−１，４−ジエン誘導体 |
| DE19633349A1 (de) | 1996-08-19 | 1998-02-26 | Sigma Tau Ind Farmaceuti | Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten |
| US6784170B2 (en) * | 2000-02-11 | 2004-08-31 | Sri International | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one |
| IT1317031B1 (it) | 2000-05-17 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi. |
| WO2002022645A2 (en) | 2000-09-14 | 2002-03-21 | Accelerated Pharmaceuticals, Inc. | Method of making 7alpha-methyl-11beta-methoxy estradiol and related compounds with estrogenic activity |
| AU2004275693A1 (en) | 2003-05-28 | 2005-04-07 | Entremed, Inc. | Antiangiogenic agents |
| US8088758B2 (en) * | 2003-11-12 | 2012-01-03 | Abbott Products Gmbh | 17β-hydroxysteroid dehydrogenase type I inhibitors |
| WO2005070951A1 (en) | 2004-01-16 | 2005-08-04 | Cedarburg Pharmaceuticals, Inc. | Exemestane and its intermediates and methods of making the same |
| US7419972B2 (en) * | 2004-07-02 | 2008-09-02 | Schering Ag | 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 |
| BRPI0616639A2 (pt) | 2005-09-30 | 2011-06-28 | Endece Llc | compostos de exemestano de (s)-6-metiloxaalquila e métodos de uso relacionados |
| TWI392682B (zh) | 2006-04-13 | 2013-04-11 | Sigma Tau Ind Farmaceuti | 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物 |
-
2008
- 2008-06-04 US US12/132,857 patent/US8168621B2/en not_active Expired - Fee Related
-
2009
- 2009-06-03 EP EP09759335.4A patent/EP2300016B1/en not_active Not-in-force
- 2009-06-03 CA CA2726364A patent/CA2726364C/en not_active Expired - Fee Related
- 2009-06-03 MX MX2010013288A patent/MX2010013288A/es active IP Right Grant
- 2009-06-03 KR KR1020107029911A patent/KR101769152B1/ko not_active Expired - Fee Related
- 2009-06-03 AU AU2009256237A patent/AU2009256237B2/en not_active Ceased
- 2009-06-03 DK DK09759335.4T patent/DK2300016T3/en active
- 2009-06-03 BR BRPI0913632A patent/BRPI0913632A2/pt not_active Application Discontinuation
- 2009-06-03 ES ES09759335.4T patent/ES2641779T3/es active Active
- 2009-06-03 NO NO09759335A patent/NO2300016T3/no unknown
- 2009-06-03 CN CN200980124997.9A patent/CN102076343B/zh not_active Expired - Fee Related
- 2009-06-03 WO PCT/US2009/046120 patent/WO2009149176A1/en not_active Ceased
- 2009-06-03 JP JP2011512613A patent/JP5727370B2/ja active Active
-
2012
- 2012-04-30 US US13/459,665 patent/US8629130B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4840943A (en) * | 1986-06-20 | 1989-06-20 | Farmitalia Carlo Ebra S.R.L. | Androst-4-ene-3,17-diones and process for their preparation |
| US6239123B1 (en) * | 1998-08-11 | 2001-05-29 | Entremed, Inc. | Use of estrogenic compounds as anti-fungal agents |
| US20080119447A1 (en) * | 2005-09-30 | 2008-05-22 | James Yarger | 6-alkoxyalkyl estradiol derivatives and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009256237A1 (en) | 2009-12-10 |
| MX2010013288A (es) | 2010-12-21 |
| JP5727370B2 (ja) | 2015-06-03 |
| BRPI0913632A2 (pt) | 2017-01-24 |
| CA2726364C (en) | 2016-10-11 |
| WO2009149176A1 (en) | 2009-12-10 |
| US8629130B2 (en) | 2014-01-14 |
| DK2300016T3 (en) | 2017-09-18 |
| JP2011522825A (ja) | 2011-08-04 |
| CN102076343B (zh) | 2015-04-01 |
| EP2300016A1 (en) | 2011-03-30 |
| US20080312202A1 (en) | 2008-12-18 |
| US20120270817A1 (en) | 2012-10-25 |
| EP2300016B1 (en) | 2017-08-09 |
| CA2726364A1 (en) | 2009-12-10 |
| EP2300016A4 (en) | 2012-01-18 |
| ES2641779T3 (es) | 2017-11-13 |
| NO2300016T3 (enExample) | 2018-01-06 |
| US8168621B2 (en) | 2012-05-01 |
| CN102076343A (zh) | 2011-05-25 |
| KR101769152B1 (ko) | 2017-08-17 |
| KR20110019767A (ko) | 2011-02-28 |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period | ||
| NB | Applications allowed - extensions of time section 223(2) |
Free format text: THE TIME IN WHICH TO REQUEST EXAMINATION HAS BEEN EXTENDED TO 25 APR 2013 . |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |