AU2009232352B2 - Beta-turn peptidomimetic cyclic compounds for treating dry eye - Google Patents

Beta-turn peptidomimetic cyclic compounds for treating dry eye Download PDF

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Publication number
AU2009232352B2
AU2009232352B2 AU2009232352A AU2009232352A AU2009232352B2 AU 2009232352 B2 AU2009232352 B2 AU 2009232352B2 AU 2009232352 A AU2009232352 A AU 2009232352A AU 2009232352 A AU2009232352 A AU 2009232352A AU 2009232352 B2 AU2009232352 B2 AU 2009232352B2
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Australia
Prior art keywords
compound
day
scopolamine
dry eye
group
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AU2009232352A
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English (en)
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AU2009232352A1 (en
Inventor
Garth Cumberlidge
Teresa Lama
Karen Meerovitch
H Uri Saragovi
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Mimetogen Pharmaceuticals Inc
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Mimetogen Pharmaceuticals Inc
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Publication of AU2009232352A1 publication Critical patent/AU2009232352A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2009232352A 2008-04-04 2009-04-03 Beta-turn peptidomimetic cyclic compounds for treating dry eye Active AU2009232352B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12303608P 2008-04-04 2008-04-04
US61/123,036 2008-04-04
US20887309P 2009-02-27 2009-02-27
US61/208,873 2009-02-27
PCT/US2009/002121 WO2009123761A1 (en) 2008-04-04 2009-04-03 Beta-turn peptidomimetic cyclic compounds for treating dry eye

Publications (2)

Publication Number Publication Date
AU2009232352A1 AU2009232352A1 (en) 2009-10-08
AU2009232352B2 true AU2009232352B2 (en) 2013-09-05

Family

ID=40897413

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009232352A Active AU2009232352B2 (en) 2008-04-04 2009-04-03 Beta-turn peptidomimetic cyclic compounds for treating dry eye

Country Status (9)

Country Link
US (4) US8293713B2 (cg-RX-API-DMAC10.html)
EP (1) EP2271337B1 (cg-RX-API-DMAC10.html)
JP (2) JP5480242B2 (cg-RX-API-DMAC10.html)
KR (1) KR101565185B1 (cg-RX-API-DMAC10.html)
CN (1) CN102046166B (cg-RX-API-DMAC10.html)
AU (1) AU2009232352B2 (cg-RX-API-DMAC10.html)
CA (1) CA2720141C (cg-RX-API-DMAC10.html)
ES (1) ES2521515T3 (cg-RX-API-DMAC10.html)
WO (1) WO2009123761A1 (cg-RX-API-DMAC10.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009232352B2 (en) 2008-04-04 2013-09-05 Mimetogen Pharmaceuticals Inc. Beta-turn peptidomimetic cyclic compounds for treating dry eye
EP2864347B1 (en) * 2012-06-22 2020-10-28 Mimetogen Pharmaceuticals, Inc. Synthesis of beta-turn peptidomimetic cyclic compounds
KR20150004652A (ko) 2013-07-03 2015-01-13 삼성디스플레이 주식회사 표시 패널, 이를 포함하는 표시 장치 및 이를 이용하는 영상 표시 방법
JP6267003B2 (ja) * 2014-02-27 2018-01-24 参天製薬株式会社 ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤
EP3244851B1 (en) 2015-01-12 2024-10-16 Bausch + Lomb Ireland Limited Micro-droplet delivery device
KR20170135862A (ko) 2015-04-10 2017-12-08 켄달리온 테라퓨틱스 인코포레이티드 교체 가능한 앰플을 갖는 압전 디스펜서
KR102056257B1 (ko) * 2015-07-09 2019-12-16 미메토젠 파르마슈티칼스 인크. 베타-턴 펩티도미메틱 사이클릭 염의 용액상 합성 및 결정화
KR101718733B1 (ko) 2015-08-21 2017-03-22 국제약품 주식회사 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제
WO2017152027A1 (en) 2016-03-04 2017-09-08 Rynerson James M Method of treating an eye disorder by inhibiting or disrupting bacterial biofilm formation
CN109906120A (zh) 2017-01-20 2019-06-18 科达莱昂治疗公司 压电流体分配器
WO2019113483A1 (en) 2017-12-08 2019-06-13 Kedalion Therapeutics, Inc. Fluid delivery alignment system
CN110092799B (zh) * 2018-01-29 2021-11-12 广州丹康医药生物有限公司 一种环状化合物、其制备方法和应用
US12350194B1 (en) 2018-04-12 2025-07-08 Bausch + Lomb Ireland Limited Topical ocular delivery of fluids with controlled mass dosing and wireless communication
WO2019200121A1 (en) 2018-04-12 2019-10-17 Kedalion Therapeutics, Inc. Topical ocular delivery methods and devices for use in the same
EP3817696B8 (en) 2018-07-03 2024-12-11 Bausch + Lomb Ireland Limited Topical ocular delivery devices
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US12097145B2 (en) 2019-03-06 2024-09-24 Bausch + Lomb Ireland Limited Vented multi-dose ocular fluid delivery system
US12496218B1 (en) 2019-11-12 2025-12-16 Bausch + Lomb Ireland Limited Fractionated topical ocular drug delivery methods and devices for use in the same
CA3180199A1 (en) 2020-04-17 2021-10-21 Yehuda Ivri Hydrodynamically actuated preservative free dispensing system
US12290472B2 (en) 2020-04-17 2025-05-06 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
EP4120973B1 (en) 2020-04-17 2026-06-10 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
US20240368225A1 (en) * 2021-06-02 2024-11-07 The Texas A&M University System Selective small molecule agonists and partial agonists of trk receptors
WO2023069549A1 (en) * 2021-10-20 2023-04-27 Stealth Biotherapeutics Inc. Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions
WO2023069255A1 (en) * 2021-10-20 2023-04-27 Stealth Biotherapeutics Inc. Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001052843A1 (en) * 2000-01-18 2001-07-26 Mcgill University β-TURN PEPTIDOMIMETIC CYCLIC COMPOUNDS
EP1734052A1 (en) * 2005-06-13 2006-12-20 Primm S.R.L. Heterodimeric peptide compounds displaying ngf activity and their use to treat neurodegenerative disorders

Family Cites Families (9)

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GB8917217D0 (en) * 1989-07-27 1989-09-13 Smith & Nephew Ophthalmic compositions
US5545617A (en) 1993-11-12 1996-08-13 The Schepens Eye Research Institute, Inc. Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion
EP1041996A4 (en) * 1997-12-22 2003-05-14 Human Genome Sciences Inc KERATINOCYTE GROWTH FACTOR-2 FORMULATIONS
JP2001064198A (ja) 1999-08-24 2001-03-13 Teika Seiyaku Kk 角膜疾患治療剤
EP1921087A1 (en) 2006-11-10 2008-05-14 Primm S.R.L. Process for the preparation of cyclic peptides
US8648169B2 (en) * 2006-12-05 2014-02-11 The Royal Institution For The Advancement Of Learning/Mcgill University Methods of use of Trk receptor modulators
AU2009232352B2 (en) * 2008-04-04 2013-09-05 Mimetogen Pharmaceuticals Inc. Beta-turn peptidomimetic cyclic compounds for treating dry eye
AU2010217889B2 (en) * 2009-02-27 2014-12-18 Mimetogen Pharmaceuticals Inc. Peptidomimetic cyclic compounds for treating retinitis pigmentosa
EP2864347B1 (en) * 2012-06-22 2020-10-28 Mimetogen Pharmaceuticals, Inc. Synthesis of beta-turn peptidomimetic cyclic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001052843A1 (en) * 2000-01-18 2001-07-26 Mcgill University β-TURN PEPTIDOMIMETIC CYCLIC COMPOUNDS
EP1734052A1 (en) * 2005-06-13 2006-12-20 Primm S.R.L. Heterodimeric peptide compounds displaying ngf activity and their use to treat neurodegenerative disorders

Also Published As

Publication number Publication date
US8748391B2 (en) 2014-06-10
AU2009232352A1 (en) 2009-10-08
HK1152898A1 (en) 2012-03-16
US9156882B2 (en) 2015-10-13
EP2271337B1 (en) 2014-09-03
CN102046166B (zh) 2012-10-17
US20140274910A1 (en) 2014-09-18
US20110105410A1 (en) 2011-05-05
CA2720141A1 (en) 2009-10-08
CA2720141C (en) 2014-01-28
JP2011516477A (ja) 2011-05-26
US20120322747A1 (en) 2012-12-20
US8293713B2 (en) 2012-10-23
US20160082072A1 (en) 2016-03-24
CN102046166A (zh) 2011-05-04
US9707267B2 (en) 2017-07-18
EP2271337A1 (en) 2011-01-12
JP5480242B2 (ja) 2014-04-23
KR101565185B1 (ko) 2015-11-02
JP5870348B2 (ja) 2016-02-24
WO2009123761A1 (en) 2009-10-08
KR20110010712A (ko) 2011-02-07
ES2521515T3 (es) 2014-11-12
JP2014080447A (ja) 2014-05-08

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