AU2009206204B2 - Delayed release pharmaceutical composition of duloxetine - Google Patents
Delayed release pharmaceutical composition of duloxetine Download PDFInfo
- Publication number
- AU2009206204B2 AU2009206204B2 AU2009206204A AU2009206204A AU2009206204B2 AU 2009206204 B2 AU2009206204 B2 AU 2009206204B2 AU 2009206204 A AU2009206204 A AU 2009206204A AU 2009206204 A AU2009206204 A AU 2009206204A AU 2009206204 B2 AU2009206204 B2 AU 2009206204B2
- Authority
- AU
- Australia
- Prior art keywords
- duloxetine
- enteric
- particle size
- coat
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 229960002866 duloxetine Drugs 0.000 title claims abstract description 98
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- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
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- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- ZEUITGRIYCTCEM-UHFFFAOYSA-N duloxetine Chemical compound C=1C=CC2=CC=CC=C2C=1OC(CCNC)C1=CC=CS1 ZEUITGRIYCTCEM-UHFFFAOYSA-N 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
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- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- FETSQPAGYOVAQU-UHFFFAOYSA-N glyceryl palmitostearate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O FETSQPAGYOVAQU-UHFFFAOYSA-N 0.000 description 1
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 235000012245 magnesium oxide Nutrition 0.000 description 1
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- FYYHWMGAXLPEAU-OUBTZVSYSA-N magnesium-25 atom Chemical compound [25Mg] FYYHWMGAXLPEAU-OUBTZVSYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 238000003921 particle size analysis Methods 0.000 description 1
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 229960000540 polacrilin potassium Drugs 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
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- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- WVWZXTJUCNEUAE-UHFFFAOYSA-M potassium;1,2-bis(ethenyl)benzene;2-methylprop-2-enoate Chemical compound [K+].CC(=C)C([O-])=O.C=CC1=CC=CC=C1C=C WVWZXTJUCNEUAE-UHFFFAOYSA-M 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
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- 210000000813 small intestine Anatomy 0.000 description 1
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- 235000010234 sodium benzoate Nutrition 0.000 description 1
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- 239000008109 sodium starch glycolate Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2009206204A AU2009206204B2 (en) | 2008-01-25 | 2009-01-09 | Delayed release pharmaceutical composition of duloxetine |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008900332A AU2008900332A0 (en) | 2008-01-25 | Delayed Release Composition and Compound | |
| AU2008900332 | 2008-01-25 | ||
| AU2009206204A AU2009206204B2 (en) | 2008-01-25 | 2009-01-09 | Delayed release pharmaceutical composition of duloxetine |
| PCT/AU2009/000028 WO2009092129A1 (en) | 2008-01-25 | 2009-01-09 | Delayed release pharmaceutical composition of duloxetine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009206204A1 AU2009206204A1 (en) | 2009-07-30 |
| AU2009206204B2 true AU2009206204B2 (en) | 2015-03-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009206204A Ceased AU2009206204B2 (en) | 2008-01-25 | 2009-01-09 | Delayed release pharmaceutical composition of duloxetine |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110070299A1 (https=) |
| EP (1) | EP2240173A4 (https=) |
| JP (1) | JP2011510024A (https=) |
| CN (1) | CN101939004A (https=) |
| AU (1) | AU2009206204B2 (https=) |
| CA (1) | CA2712282A1 (https=) |
| WO (1) | WO2009092129A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8663661B2 (en) | 2009-12-23 | 2014-03-04 | Ratiopharm Gmbh | Solid pharmaceutical dosage form of ticagrelor |
| CN102908331A (zh) * | 2011-08-01 | 2013-02-06 | 浙江九洲药物科技有限公司 | 一种盐酸度洛西汀肠溶胶囊及其制备方法 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN102579403B (zh) * | 2011-12-26 | 2013-08-21 | 天津市嵩锐医药科技有限公司 | 盐酸度洛西汀药物组合物 |
| US8313774B1 (en) * | 2012-06-26 | 2012-11-20 | Magnifica Inc. | Oral solid composition |
| CN103127023B (zh) * | 2013-03-01 | 2014-08-27 | 河北天成药业股份有限公司 | 一种盐酸度洛西汀肠溶片及其制备方法 |
| GR1008228B (el) * | 2013-04-23 | 2014-06-16 | "Φαρματεν Α.Β.Ε.Ε.", | Φαρμακευτικο σκευασμα περιεχον ενα διπλο αναστολεα επαναπροσληψης και μεθοδος για την παρασκευη αυτου |
| CN103393615B (zh) * | 2013-07-24 | 2015-07-15 | 海南华益泰康药业有限公司 | 一种度洛西汀肠溶小丸及其制备方法 |
| CN104414993A (zh) * | 2013-08-20 | 2015-03-18 | 天津药物研究院 | 一种盐酸度洛西汀肠溶微丸胶囊及其制备方法 |
| JP6815109B2 (ja) * | 2016-06-23 | 2021-01-20 | キョーリンリメディオ株式会社 | デュロキセチンまたは薬学的に許容されるその塩を有効成分とする医薬組成物 |
| JP6972674B2 (ja) * | 2017-06-06 | 2021-11-24 | ニプロ株式会社 | 経口医薬製剤 |
| JP7046323B2 (ja) * | 2017-09-13 | 2022-04-04 | アリメント工業株式会社 | 多層被覆製剤 |
| JP2020029447A (ja) * | 2018-06-25 | 2020-02-27 | 大原薬品工業株式会社 | 腸溶性高分子及び抗付着剤を含有する顆粒 |
| WO2021126098A1 (en) * | 2019-12-18 | 2021-06-24 | Santa Farma İlaç Sanayi̇ A.Ş. | Gastro-resistant pellet comprising duloxetine |
| CN116617189B (zh) * | 2023-07-26 | 2023-09-26 | 四川尚锐生物医药有限公司 | 一种盐酸度洛西汀缓释胶囊及其制备方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508276A (en) * | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
| WO2002024160A2 (en) * | 2000-09-21 | 2002-03-28 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
| WO2003094900A1 (en) * | 2002-05-13 | 2003-11-20 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
| US20040058896A1 (en) * | 2000-12-07 | 2004-03-25 | Rango Dietrich | Pharmaceutical preparation comprising an active dispersed on a matrix |
| WO2008077939A2 (en) * | 2006-12-27 | 2008-07-03 | Lek Pharmaceuticals D.D. | Duloxetine composition |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4956388A (en) * | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| US5009895A (en) * | 1990-02-02 | 1991-04-23 | Merck & Co., Inc. | Sustained release with high and low viscosity HPMC |
| US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
| ZA977967B (en) * | 1996-09-23 | 1999-03-04 | Lilly Co Eli | Combination therapy for treatment of psychoses |
| CA2362185C (en) * | 1999-04-09 | 2009-06-02 | Eli Lilly And Company | Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof |
| US6420473B1 (en) * | 2000-02-10 | 2002-07-16 | Bpsi Holdings, Inc. | Acrylic enteric coating compositions |
| AU2003287499A1 (en) * | 2002-11-19 | 2004-06-15 | Eli Lilly And Company | Treatment of gastrointestinal disorders with duloxetine |
| US7625932B2 (en) * | 2003-10-08 | 2009-12-01 | Eli Lilly And Company | Pyrrole and pyrazole derivatives as potentiators of glutamate receptors |
| US20050250838A1 (en) * | 2004-05-04 | 2005-11-10 | Challapalli Prasad V | Formulation for sustained delivery |
| KR20070087678A (ko) * | 2004-12-20 | 2007-08-28 | 컬리지움 파마슈티칼, 인코포레이티드 | 수면 장애용 약제 조성물 |
| US20100285123A1 (en) * | 2005-06-20 | 2010-11-11 | Rudresha Korlakunte Virupakshalah Prasad | Controlled Release Dosage Formulation of Duloxetine |
| WO2007077580A2 (en) | 2006-01-06 | 2007-07-12 | Msn Laboratories Limited | Improved process for pure duloxetine hydrochloride |
| EP1820800A1 (en) * | 2006-02-17 | 2007-08-22 | KRKA, tovarna zdravil, d.d., Novo mesto | Crystalline forms of duloxetine hydrochloride and processes for their preparation |
| KR20090005237A (ko) * | 2006-05-22 | 2009-01-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 둘록세틴 염산염 지연 방출형 제제 |
-
2009
- 2009-01-09 EP EP20090704911 patent/EP2240173A4/en not_active Ceased
- 2009-01-09 WO PCT/AU2009/000028 patent/WO2009092129A1/en not_active Ceased
- 2009-01-09 AU AU2009206204A patent/AU2009206204B2/en not_active Ceased
- 2009-01-09 CN CN2009801017187A patent/CN101939004A/zh active Pending
- 2009-01-09 JP JP2010543345A patent/JP2011510024A/ja active Pending
- 2009-01-09 CA CA2712282A patent/CA2712282A1/en not_active Abandoned
- 2009-01-09 US US12/863,882 patent/US20110070299A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508276A (en) * | 1994-07-18 | 1996-04-16 | Eli Lilly And Company | Duloxetine enteric pellets |
| WO2002024160A2 (en) * | 2000-09-21 | 2002-03-28 | Phase 2 Discovery, Inc. | Long acting antidepressant microparticles |
| US20040058896A1 (en) * | 2000-12-07 | 2004-03-25 | Rango Dietrich | Pharmaceutical preparation comprising an active dispersed on a matrix |
| WO2003094900A1 (en) * | 2002-05-13 | 2003-11-20 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
| WO2008077939A2 (en) * | 2006-12-27 | 2008-07-03 | Lek Pharmaceuticals D.D. | Duloxetine composition |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009092129A8 (en) | 2009-10-22 |
| CN101939004A (zh) | 2011-01-05 |
| AU2009206204A1 (en) | 2009-07-30 |
| EP2240173A4 (en) | 2013-07-17 |
| WO2009092129A1 (en) | 2009-07-30 |
| US20110070299A1 (en) | 2011-03-24 |
| JP2011510024A (ja) | 2011-03-31 |
| CA2712282A1 (en) | 2009-07-30 |
| EP2240173A1 (en) | 2010-10-20 |
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Legal Events
| Date | Code | Title | Description |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |