AU2008335031B2 - Modulators of cystic fibrosis transmembrane conductance regulator - Google Patents

Modulators of cystic fibrosis transmembrane conductance regulator Download PDF

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Publication number
AU2008335031B2
AU2008335031B2 AU2008335031A AU2008335031A AU2008335031B2 AU 2008335031 B2 AU2008335031 B2 AU 2008335031B2 AU 2008335031 A AU2008335031 A AU 2008335031A AU 2008335031 A AU2008335031 A AU 2008335031A AU 2008335031 B2 AU2008335031 B2 AU 2008335031B2
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wrw
ring
optionally substituted
compound
formula
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AU2008335031A
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AU2008335031A1 (en
Inventor
Hayley Binch
Lev T.D. Fanning
Peter D.J. Grootenhuis
Albert Pierce
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2008335031A 2007-12-13 2008-12-12 Modulators of cystic fibrosis transmembrane conductance regulator Ceased AU2008335031B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1333607P 2007-12-13 2007-12-13
US61/013,336 2007-12-13
PCT/US2008/086562 WO2009076593A1 (en) 2007-12-13 2008-12-12 Modulators of cystic fibrosis transmembrane conductance regulator

Publications (2)

Publication Number Publication Date
AU2008335031A1 AU2008335031A1 (en) 2009-06-18
AU2008335031B2 true AU2008335031B2 (en) 2013-11-28

Family

ID=40404952

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008335031A Ceased AU2008335031B2 (en) 2007-12-13 2008-12-12 Modulators of cystic fibrosis transmembrane conductance regulator

Country Status (9)

Country Link
US (2) US8552006B2 (enExample)
EP (1) EP2231671B1 (enExample)
JP (1) JP5637859B2 (enExample)
CN (1) CN101925603B (enExample)
AU (1) AU2008335031B2 (enExample)
CA (1) CA2709301C (enExample)
ES (1) ES2422741T3 (enExample)
NZ (1) NZ586271A (enExample)
WO (1) WO2009076593A1 (enExample)

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