AU2008318778B2 - Targeting microRNAs for the treatment of liver cancer - Google Patents

Targeting microRNAs for the treatment of liver cancer Download PDF

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Publication number
AU2008318778B2
AU2008318778B2 AU2008318778A AU2008318778A AU2008318778B2 AU 2008318778 B2 AU2008318778 B2 AU 2008318778B2 AU 2008318778 A AU2008318778 A AU 2008318778A AU 2008318778 A AU2008318778 A AU 2008318778A AU 2008318778 B2 AU2008318778 B2 AU 2008318778B2
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moe
certain embodiments
modified oligonucleotide
nucleobase sequence
modified
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AU2008318778A1 (en
Inventor
C. Frank Bennett
Ayelet Chajut
Christine Esau
Eric G. Marcusson
Noga Yerushalmi
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Regulus Therapeutics Inc
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Regulus Therapeutics Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
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AU2008318778A 2007-10-29 2008-10-29 Targeting microRNAs for the treatment of liver cancer Active AU2008318778B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014271307A AU2014271307A1 (en) 2007-10-29 2014-12-04 Targeting microRNAs for the treatment of liver cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98323107P 2007-10-29 2007-10-29
US60/983,231 2007-10-29
PCT/US2008/081645 WO2009058907A2 (en) 2007-10-29 2008-10-29 Targeting micrornas for the treatment of liver cancer

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AU2014271307A Division AU2014271307A1 (en) 2007-10-29 2014-12-04 Targeting microRNAs for the treatment of liver cancer

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AU2008318778A1 AU2008318778A1 (en) 2009-05-07
AU2008318778B2 true AU2008318778B2 (en) 2014-10-02

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US (6) US8211867B2 (OSRAM)
EP (1) EP2217248B1 (OSRAM)
JP (1) JP5535076B2 (OSRAM)
CN (1) CN101980712B (OSRAM)
AU (1) AU2008318778B2 (OSRAM)
CA (1) CA2704043C (OSRAM)
IL (1) IL205307A (OSRAM)
WO (1) WO2009058907A2 (OSRAM)

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