AU2008311154B2 - 5-HT7 receptor antagonists - Google Patents

5-HT7 receptor antagonists Download PDF

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Publication number
AU2008311154B2
AU2008311154B2 AU2008311154A AU2008311154A AU2008311154B2 AU 2008311154 B2 AU2008311154 B2 AU 2008311154B2 AU 2008311154 A AU2008311154 A AU 2008311154A AU 2008311154 A AU2008311154 A AU 2008311154A AU 2008311154 B2 AU2008311154 B2 AU 2008311154B2
Authority
AU
Australia
Prior art keywords
pharmaceutically acceptable
acceptable salt
tetrahydro
compound according
pyrazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008311154A
Other languages
English (en)
Other versions
AU2008311154A1 (en
Inventor
Valentina O. Badescu
Sandra Ann Filla
Peter Thaddeus Gallagher
Maria Ann Whatton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2008311154A1 publication Critical patent/AU2008311154A1/en
Application granted granted Critical
Publication of AU2008311154B2 publication Critical patent/AU2008311154B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2008311154A 2007-10-12 2008-09-30 5-HT7 receptor antagonists Ceased AU2008311154B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97946407P 2007-10-12 2007-10-12
US60/979,464 2007-10-12
PCT/US2008/078294 WO2009048765A1 (en) 2007-10-12 2008-09-30 5-ht7 receptor antagonists

Publications (2)

Publication Number Publication Date
AU2008311154A1 AU2008311154A1 (en) 2009-04-16
AU2008311154B2 true AU2008311154B2 (en) 2013-09-26

Family

ID=40134870

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008311154A Ceased AU2008311154B2 (en) 2007-10-12 2008-09-30 5-HT7 receptor antagonists

Country Status (19)

Country Link
US (1) US7910588B2 (enExample)
EP (1) EP2201002B1 (enExample)
JP (1) JP5291716B2 (enExample)
KR (1) KR101161070B1 (enExample)
CN (1) CN101821257B (enExample)
AT (1) ATE548365T1 (enExample)
AU (1) AU2008311154B2 (enExample)
BR (1) BRPI0818450A2 (enExample)
CA (1) CA2699674C (enExample)
CY (1) CY1112709T1 (enExample)
DK (1) DK2201002T3 (enExample)
EA (1) EA016787B1 (enExample)
ES (1) ES2380756T3 (enExample)
HR (1) HRP20120257T1 (enExample)
MX (1) MX2010003986A (enExample)
PL (1) PL2201002T3 (enExample)
PT (1) PT2201002E (enExample)
SI (1) SI2201002T1 (enExample)
WO (1) WO2009048765A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI396857B (zh) * 2009-12-30 2013-05-21 Etron Technology Inc 晶片測試電路
WO2013053725A1 (en) 2011-10-11 2013-04-18 Ucb Pharma, S.A. 2-oxo-piperidinyl derivatives
WO2014164756A1 (en) 2013-03-11 2014-10-09 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
TW201601632A (zh) * 2013-11-20 2016-01-16 杜邦股份有限公司 １－芳基－３－烷基吡唑殺蟲劑
EP3200589B1 (en) 2014-09-10 2026-03-11 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
EP3541790B1 (en) 2016-11-15 2025-09-03 Temple University - Of The Commonwealth System of Higher Education 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression
JP7365238B2 (ja) 2017-03-21 2023-10-19 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション ５－ヒドロキシトリプタミン受容体７調節物質および治療剤としてのその使用
BR112020023072A2 (pt) 2018-05-11 2021-02-02 Temple University-Of The Commonwealth System Of Higher Education novos lactâmicos funcionalizados como moduladores do receptor 7 de 5-hidroxitriptamina e seu método de uso

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067703A2 (en) * 2003-01-31 2004-08-12 Pfizer Products Inc. 5ht7 antagonists and inverse agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US20030008880A1 (en) 2001-05-02 2003-01-09 Pfizer Inc. 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity
US7211783B2 (en) 2004-01-09 2007-05-01 Tamperproof Container Licensing Corp. Tamper-proof container
CA2568524A1 (en) 2004-05-28 2005-12-15 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
TW200914020A (en) * 2007-08-28 2009-04-01 Lilly Co Eli Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067703A2 (en) * 2003-01-31 2004-08-12 Pfizer Products Inc. 5ht7 antagonists and inverse agonists

Also Published As

Publication number Publication date
US7910588B2 (en) 2011-03-22
PL2201002T3 (pl) 2012-07-31
EP2201002B1 (en) 2012-03-07
AU2008311154A1 (en) 2009-04-16
ES2380756T3 (es) 2012-05-18
SI2201002T1 (sl) 2012-04-30
PT2201002E (pt) 2012-04-27
WO2009048765A1 (en) 2009-04-16
EA201070462A1 (ru) 2010-10-29
JP5291716B2 (ja) 2013-09-18
US20100197700A1 (en) 2010-08-05
DK2201002T3 (da) 2012-04-10
ATE548365T1 (de) 2012-03-15
BRPI0818450A2 (pt) 2015-05-12
CA2699674A1 (en) 2009-04-16
CY1112709T1 (el) 2016-02-10
EP2201002A1 (en) 2010-06-30
CN101821257A (zh) 2010-09-01
CA2699674C (en) 2013-07-16
KR101161070B1 (ko) 2012-07-13
CN101821257B (zh) 2013-05-22
MX2010003986A (es) 2010-04-27
KR20100054853A (ko) 2010-05-25
EA016787B1 (ru) 2012-07-30
HRP20120257T1 (hr) 2012-04-30
JP2011500575A (ja) 2011-01-06

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired