KR101161070B1 - 5-ｈｔ7 수용체 길항제 - Google Patents

5-ｈｔ7 수용체 길항제 Download PDF

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Publication number
KR101161070B1
KR101161070B1 KR1020107007725A KR20107007725A KR101161070B1 KR 101161070 B1 KR101161070 B1 KR 101161070B1 KR 1020107007725 A KR1020107007725 A KR 1020107007725A KR 20107007725 A KR20107007725 A KR 20107007725A KR 101161070 B1 KR101161070 B1 KR 101161070B1
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South Korea
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mmol
methyl
compound
added
ethyl
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KR1020107007725A
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English (en)
Korean (ko)
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KR20100054853A (ko
Inventor
발렌티나 오. 바데스쿠
샌드라 앤 필라
피터 쌔디어스 갤러거
마리아 앤 와튼
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020107007725A 2007-10-12 2008-09-30 5-ｈｔ7 수용체 길항제 Expired - Fee Related KR101161070B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97946407P 2007-10-12 2007-10-12
US60/979,464 2007-10-12
PCT/US2008/078294 WO2009048765A1 (en) 2007-10-12 2008-09-30 5-ht7 receptor antagonists

Publications (2)

Publication Number Publication Date
KR20100054853A KR20100054853A (ko) 2010-05-25
KR101161070B1 true KR101161070B1 (ko) 2012-07-13

Family

ID=40134870

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107007725A Expired - Fee Related KR101161070B1 (ko) 2007-10-12 2008-09-30 5-ｈｔ7 수용체 길항제

Country Status (19)

Country Link
US (1) US7910588B2 (enExample)
EP (1) EP2201002B1 (enExample)
JP (1) JP5291716B2 (enExample)
KR (1) KR101161070B1 (enExample)
CN (1) CN101821257B (enExample)
AT (1) ATE548365T1 (enExample)
AU (1) AU2008311154B2 (enExample)
BR (1) BRPI0818450A2 (enExample)
CA (1) CA2699674C (enExample)
CY (1) CY1112709T1 (enExample)
DK (1) DK2201002T3 (enExample)
EA (1) EA016787B1 (enExample)
ES (1) ES2380756T3 (enExample)
HR (1) HRP20120257T1 (enExample)
MX (1) MX2010003986A (enExample)
PL (1) PL2201002T3 (enExample)
PT (1) PT2201002E (enExample)
SI (1) SI2201002T1 (enExample)
WO (1) WO2009048765A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI396857B (zh) * 2009-12-30 2013-05-21 Etron Technology Inc 晶片測試電路
ES2546317T3 (es) 2011-10-11 2015-09-22 Ucb Biopharma Sprl Derivados de 2-oxo-piperidinilo
WO2014164756A1 (en) 2013-03-11 2014-10-09 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
TW201601632A (zh) * 2013-11-20 2016-01-16 杜邦股份有限公司 １－芳基－３－烷基吡唑殺蟲劑
WO2016040554A1 (en) 2014-09-10 2016-03-17 Temple University-Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
ES3050660T3 (en) 2016-11-15 2025-12-22 Univ Temple 3-(2-(4-phenylpiperazin-1-yl)ethyl)-2-oxa-8-azaspiro[4.5]decan-1-one derivatives and related compounds as 5-hydroxytryptamine receptor 7 (5-ht7) modulators for treating e.g. inflammatory bowel disease, circadian rhythm disorder or depression
US11220505B2 (en) 2017-03-21 2022-01-11 Temple University-Of The Commonwealth System Of Higher Education 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents
MA52567A (fr) 2018-05-11 2021-03-17 Praeventix Llc Nouveaux lactames fonctionnalisés en tant que modulateurs du récepteur de 5-hydroxytryptamine 7 et leur procédé d'utilisation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465467B1 (en) * 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US20030008880A1 (en) 2001-05-02 2003-01-09 Pfizer Inc. 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity
EP1592772A2 (en) * 2003-01-31 2005-11-09 Pfizer Products Incorporated 5ht7 antagonists and inverse agonists
US7211783B2 (en) 2004-01-09 2007-05-01 Tamperproof Container Licensing Corp. Tamper-proof container
CN101005842A (zh) 2004-05-28 2007-07-25 弗特克斯药品有限公司 蕈毒碱性受体调节剂
TW200914020A (en) * 2007-08-28 2009-04-01 Lilly Co Eli Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists

Also Published As

Publication number Publication date
CA2699674A1 (en) 2009-04-16
JP5291716B2 (ja) 2013-09-18
BRPI0818450A2 (pt) 2015-05-12
WO2009048765A1 (en) 2009-04-16
ES2380756T3 (es) 2012-05-18
US20100197700A1 (en) 2010-08-05
CA2699674C (en) 2013-07-16
CN101821257A (zh) 2010-09-01
ATE548365T1 (de) 2012-03-15
MX2010003986A (es) 2010-04-27
EP2201002A1 (en) 2010-06-30
HRP20120257T1 (hr) 2012-04-30
DK2201002T3 (da) 2012-04-10
PT2201002E (pt) 2012-04-27
EA016787B1 (ru) 2012-07-30
EP2201002B1 (en) 2012-03-07
AU2008311154A1 (en) 2009-04-16
KR20100054853A (ko) 2010-05-25
CN101821257B (zh) 2013-05-22
JP2011500575A (ja) 2011-01-06
SI2201002T1 (sl) 2012-04-30
PL2201002T3 (pl) 2012-07-31
AU2008311154B2 (en) 2013-09-26
US7910588B2 (en) 2011-03-22
EA201070462A1 (ru) 2010-10-29
CY1112709T1 (el) 2016-02-10

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