AU2008293715B2 - Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists - Google Patents

Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists Download PDF

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Publication number
AU2008293715B2
AU2008293715B2 AU2008293715A AU2008293715A AU2008293715B2 AU 2008293715 B2 AU2008293715 B2 AU 2008293715B2 AU 2008293715 A AU2008293715 A AU 2008293715A AU 2008293715 A AU2008293715 A AU 2008293715A AU 2008293715 B2 AU2008293715 B2 AU 2008293715B2
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AU
Australia
Prior art keywords
methyl
pharmaceutically acceptable
ethyl
acceptable salt
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008293715A
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English (en)
Other versions
AU2008293715A1 (en
Inventor
Michael Philip Cohen
Sandra Ann Filla
Sarah Lynne Hellman
Sean Patrick Hollinshead
Michael Wade Tidwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
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Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2008293715A1 publication Critical patent/AU2008293715A1/en
Application granted granted Critical
Publication of AU2008293715B2 publication Critical patent/AU2008293715B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2008293715A 2007-08-28 2008-08-19 Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists Ceased AU2008293715B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US96834407P 2007-08-28 2007-08-28
US60/968,344 2007-08-28
US4875208P 2008-04-29 2008-04-29
US61/048,752 2008-04-29
PCT/US2008/073543 WO2009029439A1 (en) 2007-08-28 2008-08-19 Substituted piperazinyl pyrazines and pyridines as 5-ht7 receptor antagonists

Publications (2)

Publication Number Publication Date
AU2008293715A1 AU2008293715A1 (en) 2009-03-05
AU2008293715B2 true AU2008293715B2 (en) 2013-09-19

Family

ID=39873874

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008293715A Ceased AU2008293715B2 (en) 2007-08-28 2008-08-19 Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists

Country Status (21)

Country Link
US (1) US8048884B2 (OSRAM)
EP (1) EP2188268B1 (OSRAM)
JP (1) JP5290293B2 (OSRAM)
KR (1) KR101148616B1 (OSRAM)
CN (1) CN101790522B (OSRAM)
AR (1) AR068111A1 (OSRAM)
AT (1) ATE520673T1 (OSRAM)
AU (1) AU2008293715B2 (OSRAM)
BR (1) BRPI0816468A2 (OSRAM)
CA (1) CA2694911C (OSRAM)
CY (1) CY1111848T1 (OSRAM)
DK (1) DK2188268T3 (OSRAM)
EA (1) EA017809B1 (OSRAM)
HR (1) HRP20110624T1 (OSRAM)
MX (1) MX2010002352A (OSRAM)
PE (1) PE20090629A1 (OSRAM)
PL (1) PL2188268T3 (OSRAM)
PT (1) PT2188268E (OSRAM)
SI (1) SI2188268T1 (OSRAM)
TW (1) TW200914020A (OSRAM)
WO (1) WO2009029439A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI118473B (fi) 2006-02-17 2007-11-30 Outotec Oyj Menetelmä kuparin talteenottamiseksi kuparisulfidimalmista
JP5291716B2 (ja) * 2007-10-12 2013-09-18 イーライ リリー アンド カンパニー ５−ｈｔ７受容体拮抗薬
WO2011128304A2 (de) 2010-04-16 2011-10-20 Bayer Cropscience Ag Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel
WO2013053725A1 (en) 2011-10-11 2013-04-18 Ucb Pharma, S.A. 2-oxo-piperidinyl derivatives
FR2995605B1 (fr) 2012-09-18 2014-09-19 Sanofi Sa Derives de macrolides, leur preparation et leur application therapeutique.
CN105829287B (zh) 2013-12-20 2019-08-27 埃斯蒂文制药股份有限公司 具有抗疼痛的多重模式活性的哌嗪衍生物
US11505529B2 (en) 2017-03-03 2022-11-22 National Taiwan University 8-phenyl-isoquinolines and pharmaceutical composition thereof used in the treatment of irritable bowel syndrome
KR102014335B1 (ko) * 2017-12-01 2019-08-26 한국과학기술연구원 5-ht7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1254905B1 (en) * 2001-05-02 2003-12-17 Pfizer Products Inc. 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity
WO2004067703A2 (en) * 2003-01-31 2004-08-12 Pfizer Products Inc. 5ht7 antagonists and inverse agonists
WO2004069794A2 (en) * 2003-01-31 2004-08-19 Predix Pharmaceuticals Holdings, Inc. New arylpiperazinyl compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002536434A (ja) * 1999-02-10 2002-10-29 イーライ・リリー・アンド・カンパニー ５−ｈｔ１ｆアゴニスト

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1254905B1 (en) * 2001-05-02 2003-12-17 Pfizer Products Inc. 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity
WO2004067703A2 (en) * 2003-01-31 2004-08-12 Pfizer Products Inc. 5ht7 antagonists and inverse agonists
WO2004069794A2 (en) * 2003-01-31 2004-08-19 Predix Pharmaceuticals Holdings, Inc. New arylpiperazinyl compounds

Also Published As

Publication number Publication date
MX2010002352A (es) 2010-08-04
HRP20110624T1 (hr) 2011-09-30
CN101790522A (zh) 2010-07-28
CA2694911C (en) 2013-05-07
EA201070321A1 (ru) 2010-08-30
US8048884B2 (en) 2011-11-01
AR068111A1 (es) 2009-11-04
BRPI0816468A2 (pt) 2015-03-24
ATE520673T1 (de) 2011-09-15
CY1111848T1 (el) 2015-10-07
EP2188268A1 (en) 2010-05-26
CA2694911A1 (en) 2009-03-05
JP2010537994A (ja) 2010-12-09
KR101148616B1 (ko) 2012-05-21
PT2188268E (pt) 2011-10-03
KR20100038117A (ko) 2010-04-12
TW200914020A (en) 2009-04-01
JP5290293B2 (ja) 2013-09-18
DK2188268T3 (da) 2011-10-03
EA017809B1 (ru) 2013-03-29
EP2188268B1 (en) 2011-08-17
AU2008293715A1 (en) 2009-03-05
PE20090629A1 (es) 2009-05-16
SI2188268T1 (sl) 2011-11-30
CN101790522B (zh) 2012-06-27
WO2009029439A1 (en) 2009-03-05
US20100075976A1 (en) 2010-03-25
PL2188268T3 (pl) 2011-12-30

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired