AU2008273891B2 - Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K - Google Patents

Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K Download PDF

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Publication number
AU2008273891B2
AU2008273891B2 AU2008273891A AU2008273891A AU2008273891B2 AU 2008273891 B2 AU2008273891 B2 AU 2008273891B2 AU 2008273891 A AU2008273891 A AU 2008273891A AU 2008273891 A AU2008273891 A AU 2008273891A AU 2008273891 B2 AU2008273891 B2 AU 2008273891B2
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alkyl
amino
alkoxy
bis
formula
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AU2008273891A
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AU2008273891A1 (en
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Kurt Gordon Pike
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2008273891A 2007-07-09 2008-07-08 Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K Ceased AU2008273891B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94853907P 2007-07-09 2007-07-09
US60/948,539 2007-07-09
PCT/GB2008/050548 WO2009007750A1 (en) 2007-07-09 2008-07-08 Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k

Publications (2)

Publication Number Publication Date
AU2008273891A1 AU2008273891A1 (en) 2009-01-15
AU2008273891B2 true AU2008273891B2 (en) 2012-01-12

Family

ID=39791229

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008273891A Ceased AU2008273891B2 (en) 2007-07-09 2008-07-08 Morpholino pyrimidine derivatives used in diseases linked to mTOR kinase and/or PI3K

Country Status (21)

Country Link
US (1) US8138183B2 (OSRAM)
EP (1) EP2176238B1 (OSRAM)
JP (1) JP5508260B2 (OSRAM)
KR (1) KR20100042280A (OSRAM)
CN (1) CN101809002B (OSRAM)
AR (1) AR070079A1 (OSRAM)
AT (1) ATE554075T1 (OSRAM)
AU (1) AU2008273891B2 (OSRAM)
BR (1) BRPI0814688A2 (OSRAM)
CA (1) CA2692720A1 (OSRAM)
CL (1) CL2008003940A1 (OSRAM)
CO (1) CO6251364A2 (OSRAM)
CR (1) CR11200A (OSRAM)
DO (1) DOP2010000012A (OSRAM)
EA (1) EA018708B1 (OSRAM)
EC (1) ECSP109935A (OSRAM)
ES (1) ES2385692T3 (OSRAM)
NI (1) NI201000002A (OSRAM)
PE (1) PE20100138A1 (OSRAM)
WO (1) WO2009007750A1 (OSRAM)
ZA (1) ZA200909224B (OSRAM)

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Also Published As

Publication number Publication date
CA2692720A1 (en) 2009-01-15
CL2008003940A1 (es) 2010-09-24
EA018708B1 (ru) 2013-10-30
WO2009007750A1 (en) 2009-01-15
CR11200A (es) 2010-06-17
EA201000091A1 (ru) 2010-06-30
CN101809002A (zh) 2010-08-18
EP2176238A1 (en) 2010-04-21
HK1142906A1 (en) 2010-12-17
CO6251364A2 (es) 2011-02-21
ES2385692T3 (es) 2012-07-30
NI201000002A (es) 2010-10-12
US8138183B2 (en) 2012-03-20
ATE554075T1 (de) 2012-05-15
PE20100138A1 (es) 2010-03-20
BRPI0814688A2 (pt) 2017-06-06
AU2008273891A1 (en) 2009-01-15
EP2176238B1 (en) 2012-04-18
DOP2010000012A (es) 2010-01-31
CN101809002B (zh) 2013-03-27
JP5508260B2 (ja) 2014-05-28
ZA200909224B (en) 2011-05-25
US20100249131A1 (en) 2010-09-30
KR20100042280A (ko) 2010-04-23
JP2010533160A (ja) 2010-10-21
ECSP109935A (es) 2010-03-31
AR070079A1 (es) 2010-03-10

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