AU2008265045B2 - Phenothiazine compounds for treating Mild Cognitive Impairment - Google Patents

Phenothiazine compounds for treating Mild Cognitive Impairment Download PDF

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Publication number
AU2008265045B2
AU2008265045B2 AU2008265045A AU2008265045A AU2008265045B2 AU 2008265045 B2 AU2008265045 B2 AU 2008265045B2 AU 2008265045 A AU2008265045 A AU 2008265045A AU 2008265045 A AU2008265045 A AU 2008265045A AU 2008265045 B2 AU2008265045 B2 AU 2008265045B2
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AU
Australia
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substituted
alkyl
aliphatic
independently selected
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AU2008265045A
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AU2008265045A1 (en
Inventor
Serena Deiana
Elizabeth Anne Goatman
Dominic Venay Harbaran
Alison Dorothy Murray
Gernot Riedel
Roger Todd Staff
Claude Michel Wischik
Damon Jude Wischik
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Wista Laboratories Ltd
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Wista Laboratories Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2008265045A 2007-06-19 2008-06-17 Phenothiazine compounds for treating Mild Cognitive Impairment Active AU2008265045B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94500607P 2007-06-19 2007-06-19
US60/945,006 2007-06-19
PCT/GB2008/002066 WO2008155533A2 (en) 2007-06-19 2008-06-17 Phenothiazine compounds for treating mild cognitive impairment

Publications (2)

Publication Number Publication Date
AU2008265045A1 AU2008265045A1 (en) 2008-12-24
AU2008265045B2 true AU2008265045B2 (en) 2014-02-27

Family

ID=39943003

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008265045A Active AU2008265045B2 (en) 2007-06-19 2008-06-17 Phenothiazine compounds for treating Mild Cognitive Impairment

Country Status (16)

Country Link
US (1) US9211294B2 (cg-RX-API-DMAC7.html)
EP (1) EP2167095B1 (cg-RX-API-DMAC7.html)
JP (1) JP5725605B2 (cg-RX-API-DMAC7.html)
CN (1) CN101820884B (cg-RX-API-DMAC7.html)
AU (1) AU2008265045B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0813670A2 (cg-RX-API-DMAC7.html)
CA (1) CA2690746C (cg-RX-API-DMAC7.html)
DK (1) DK2167095T3 (cg-RX-API-DMAC7.html)
ES (1) ES2739546T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20191513T1 (cg-RX-API-DMAC7.html)
HU (1) HUE045460T2 (cg-RX-API-DMAC7.html)
MY (1) MY177001A (cg-RX-API-DMAC7.html)
PL (1) PL2167095T3 (cg-RX-API-DMAC7.html)
PT (1) PT2167095T (cg-RX-API-DMAC7.html)
SI (1) SI2167095T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008155533A2 (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109384741B (zh) 2006-03-29 2023-01-06 维斯塔实验室有限公司 3,7-二氨基-10h-吩噻嗪化合物盐及其用途
PL2205245T3 (pl) * 2007-10-03 2015-12-31 Wista Lab Ltd Zastosowanie terapeutyczne diaminofenotiazyn
US8828986B2 (en) 2011-04-20 2014-09-09 Prosetta Antiviral Inc. Antiviral compounds
JP5868955B2 (ja) 2010-04-30 2016-02-24 プロセッタ アンチバイラル インコーポレイテッド 抗ウイルス化合物
AU2011358840B2 (en) * 2011-02-11 2017-05-04 TauRx Therapeutics Management Ltd Phenothiazine diaminium salts and their use
PL3470390T3 (pl) * 2013-01-30 2023-11-06 Ecolab Usa Inc. Zmiatacze siarkowodoru
US10304006B2 (en) * 2013-02-15 2019-05-28 The Charles Stark Draper Laboratory, Inc. Method for integrating and fusing heterogeneous data types to perform predictive analysis
WO2016133995A1 (en) * 2015-02-17 2016-08-25 Arizona Board Of Regents On Behalf Of Arizona State University Phenothiazine analogues as mitochondrial therapeutic agents
EP4223297A3 (en) * 2016-07-25 2023-11-15 WisTa Laboratories Ltd. Administration and dosage of diaminophenothiazines
GB201614834D0 (en) * 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
FI3826639T3 (fi) * 2018-07-26 2024-10-30 Wista Lab Ltd Diaminofenotiatsiinien optimoitu annostus populaatioille
MY209608A (en) * 2019-04-10 2025-07-24 Genting Taurx Diagnostic Centre Sdn Bhd Adaptive neurological testing method
GB201909454D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Enhancers
GB201909493D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Therapeutic interactions
GB201909506D0 (en) 2019-07-02 2019-08-14 Wista Lab Ltd Synaptopathies
CA3257856A1 (en) 2022-05-31 2023-12-07 Wista Laboratories Ltd. TREATMENT OF NEURODEGENERATIVE DISORDERS USING COMPOUNDS CONTAINING METHYLTHIONINIUM (MT)
AU2024231880A1 (en) 2023-03-03 2025-09-11 Taurx Therapeutics Management Ltd. Diaminophenothiazine for the treatment of microvascular brain disease disease

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996030766A1 (en) * 1995-03-27 1996-10-03 F. Hoffmann-La Roche Ag Inhibition of tau-tau-association
WO2002055720A2 (en) * 2001-01-15 2002-07-18 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
WO2006032879A2 (en) * 2004-09-23 2006-03-30 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc)
WO2007110629A1 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd Inhibitors of protein aggregation
WO2007110630A1 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd. Thioninium compounds and their use
WO2007110627A2 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazine salts and their use
WO2008007074A2 (en) * 2006-07-11 2008-01-17 Wista Laboratories Ltd. Methods of synthesis and/or purification of diaminophenothiazinium compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0017060D0 (en) * 2000-07-11 2000-08-30 Hunter Fleming Ltd Production, stabilisation and use of reduced forms of pharmaceutical compounds
WO2004087160A1 (en) * 2003-04-03 2004-10-14 Prana Biotechnology Ltd Treatment of neurological conditions
CN101084204B (zh) * 2004-09-23 2012-12-05 卫思道制药有限公司 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法
WO2006091728A2 (en) * 2005-02-24 2006-08-31 The Trustees Of The University Of Pennsylvania Microtubule stabilizing compounds and methods of their use

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996030766A1 (en) * 1995-03-27 1996-10-03 F. Hoffmann-La Roche Ag Inhibition of tau-tau-association
WO2002055720A2 (en) * 2001-01-15 2002-07-18 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
WO2006032879A2 (en) * 2004-09-23 2006-03-30 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc)
WO2007110629A1 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd Inhibitors of protein aggregation
WO2007110630A1 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd. Thioninium compounds and their use
WO2007110627A2 (en) * 2006-03-29 2007-10-04 Wista Laboratories Ltd. 3,7-diamino-10h-phenothiazine salts and their use
WO2008007074A2 (en) * 2006-07-11 2008-01-17 Wista Laboratories Ltd. Methods of synthesis and/or purification of diaminophenothiazinium compounds

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Callaway, Narriman Lee et al. "Methylene blue improves brain oxidative metabolism and memory retention in rats" Pharmacology, Biochemistry and Behavior (2004) Vol.77 No.1 pages 175 to 181 *
Callaway, Narriman Lee et al. "Methylene blue restores spatial memory retention impaired by an inhibitor of cytochrome oxidase in rats" Neuroscience Letters (2002) Vol.332 No.2 pages 83 to 86 *
Dickey, Chad A. et al. "Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression" Molecular Degeneration (2006) Vol.1 pages 1 to 9 *
Riha, Penny D et al. "Memory facilitation by methylene blue: Dose-dependent effect on behavior and brain oxygen consumption" European Journal of Pharmacology (2005) Vol.511 No.2-3 pages 151 to 158 *
Wrubel, Kathryn M. et al. "The brain metabolic enhancer methylene blue improves discrimination learning in rats" Pharmacology, Biochemistry and Behavior (2007) Vol.86 No.4 pages 712 to 717 *

Also Published As

Publication number Publication date
CN101820884A (zh) 2010-09-01
SI2167095T1 (sl) 2019-09-30
WO2008155533A3 (en) 2009-02-19
MY177001A (en) 2020-09-01
JP5725605B2 (ja) 2015-05-27
PT2167095T (pt) 2019-08-06
EP2167095B1 (en) 2019-05-29
HUE045460T2 (hu) 2019-12-30
DK2167095T3 (da) 2019-07-29
BRPI0813670A2 (pt) 2014-12-30
PL2167095T3 (pl) 2019-11-29
US20100184752A1 (en) 2010-07-22
CN101820884B (zh) 2013-08-28
WO2008155533A2 (en) 2008-12-24
EP2167095A2 (en) 2010-03-31
CA2690746A1 (en) 2008-12-24
AU2008265045A1 (en) 2008-12-24
JP2010530403A (ja) 2010-09-09
CA2690746C (en) 2018-01-02
ES2739546T3 (es) 2020-01-31
HRP20191513T1 (hr) 2019-11-29
US9211294B2 (en) 2015-12-15

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