AU2008261803A1 - Therapeutic pyrazolonaphthyridine derivatives - Google Patents

Therapeutic pyrazolonaphthyridine derivatives Download PDF

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Publication number
AU2008261803A1
AU2008261803A1 AU2008261803A AU2008261803A AU2008261803A1 AU 2008261803 A1 AU2008261803 A1 AU 2008261803A1 AU 2008261803 A AU2008261803 A AU 2008261803A AU 2008261803 A AU2008261803 A AU 2008261803A AU 2008261803 A1 AU2008261803 A1 AU 2008261803A1
Authority
AU
Australia
Prior art keywords
alkyl
compound
animal
optionally substituted
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2008261803A
Other languages
English (en)
Inventor
Varsha Gupta
Alan P. Kaplan
Jan W. F. Wasley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helicon Therapeutics Inc
Original Assignee
Helicon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helicon Therapeutics Inc filed Critical Helicon Therapeutics Inc
Publication of AU2008261803A1 publication Critical patent/AU2008261803A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2008261803A 2007-06-08 2008-06-06 Therapeutic pyrazolonaphthyridine derivatives Abandoned AU2008261803A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94300007P 2007-06-08 2007-06-08
US60/943,000 2007-06-08
PCT/US2008/066211 WO2008154447A1 (en) 2007-06-08 2008-06-06 Therapeutic pyrazolonaphthyridine derivatives

Publications (1)

Publication Number Publication Date
AU2008261803A1 true AU2008261803A1 (en) 2008-12-18

Family

ID=40130166

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008261803A Abandoned AU2008261803A1 (en) 2007-06-08 2008-06-06 Therapeutic pyrazolonaphthyridine derivatives

Country Status (12)

Country Link
US (2) US7858614B2 (enExample)
EP (1) EP2166853B1 (enExample)
JP (1) JP2010529145A (enExample)
KR (1) KR20100036306A (enExample)
CN (1) CN101754681A (enExample)
AU (1) AU2008261803A1 (enExample)
BR (1) BRPI0812369A2 (enExample)
CA (1) CA2689934A1 (enExample)
ES (1) ES2483728T3 (enExample)
IL (1) IL202287A0 (enExample)
MX (1) MX2009013197A (enExample)
WO (1) WO2008154447A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008154442A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline urea derivatives
EP2627655B1 (en) * 2010-10-14 2015-09-16 Dart Neuroscience (Cayman) Ltd FUSED 3-OXO-PYRAZOLO[4,3-c]PYRIDINE COMPOUNDS AS GABAA MODULATORS
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
US10531200B2 (en) * 2015-10-23 2020-01-07 Harman International Industries, Incorporated Dual asymmetric compression driver
CN106810550A (zh) * 2017-01-10 2017-06-09 湖南华腾制药有限公司 一种萘啶衍生物的制备方法
US11485733B2 (en) 2017-06-30 2022-11-01 Bayer Animal Health Gmbh Azaquinoline derivatives

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204126A1 (de) * 1982-02-06 1983-08-11 Bayer Ag, 5090 Leverkusen Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4479955A (en) * 1983-01-10 1984-10-30 Ciba-Geigy Corporation Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators
US4814450A (en) 1984-07-09 1989-03-21 Ciba-Geigy Corporation Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives
JPS61112075A (ja) * 1984-11-05 1986-05-30 Shionogi & Co Ltd チエニルピラゾロキノリン誘導体
EP0214092A1 (en) 1985-08-08 1987-03-11 Ciba-Geigy Ag Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone
US4817450A (en) * 1987-11-30 1989-04-04 Spedco, Inc. Pressure/temperature test plug assembly
FR2695126B1 (fr) * 1992-08-27 1994-11-10 Sanofi Elf Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.
US5334595A (en) * 1992-10-23 1994-08-02 Sterling Winthrop Inc. Pyrazoloquinolones as anticancer agents
EP0760819B1 (en) * 1994-05-24 2000-07-19 F. Hoffmann-La Roche Ag Tricyclic dicarbonyl derivatives
GB9716345D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
GB9716347D0 (en) 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
GB9716344D0 (en) * 1997-08-01 1997-10-08 Merck Sharp & Dohme Therapeutic compounds
TWI271406B (en) * 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
JP3896309B2 (ja) * 2001-07-09 2007-03-22 ファイザー株式会社 プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体
WO2004055014A1 (en) * 2002-12-16 2004-07-01 Active Biotech Ab Tetracyclic immunomodulatory compounds
AR045689A1 (es) * 2003-05-29 2005-11-09 Millennium Pharm Inc Compuestos derivados de 2,5-dihidro-pirazolo[4,3-c]quinolin-4-ona como inhibidores de chk-1 y composiciones farmaceuticas que los contienen
CN1893943A (zh) * 2003-10-03 2007-01-10 3M创新有限公司 吡唑并吡啶和其类似物
US7544697B2 (en) * 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
CA2621560A1 (en) * 2005-09-07 2007-03-15 Braincells, Inc. Modulation of neurogenesis by hdac inhibition
JP2010529143A (ja) * 2007-06-08 2010-08-26 ヘリコン・セラピューティクス・インコーポレーテッド 治療用ピラゾロキノリン誘導体

Also Published As

Publication number Publication date
EP2166853A1 (en) 2010-03-31
US8497262B2 (en) 2013-07-30
CN101754681A (zh) 2010-06-23
US20110065692A1 (en) 2011-03-17
EP2166853B1 (en) 2014-05-28
US7858614B2 (en) 2010-12-28
CA2689934A1 (en) 2008-12-18
EP2166853A4 (en) 2011-04-06
KR20100036306A (ko) 2010-04-07
IL202287A0 (en) 2010-06-16
US20090005365A1 (en) 2009-01-01
JP2010529145A (ja) 2010-08-26
ES2483728T3 (es) 2014-08-07
WO2008154447A1 (en) 2008-12-18
HK1142774A1 (en) 2010-12-17
BRPI0812369A2 (pt) 2016-08-09
MX2009013197A (es) 2010-04-27

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application