CA2689934A1 - Therapeutic pyrazolonaphthyridine derivatives - Google Patents
Therapeutic pyrazolonaphthyridine derivatives Download PDFInfo
- Publication number
- CA2689934A1 CA2689934A1 CA2689934A CA2689934A CA2689934A1 CA 2689934 A1 CA2689934 A1 CA 2689934A1 CA 2689934 A CA2689934 A CA 2689934A CA 2689934 A CA2689934 A CA 2689934A CA 2689934 A1 CA2689934 A1 CA 2689934A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- compound
- animal
- optionally substituted
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 *=C(C1)NCCN1c(nc1C2=NN3c4ccccc4)ccc1NC=C2C3=O Chemical compound *=C(C1)NCCN1c(nc1C2=NN3c4ccccc4)ccc1NC=C2C3=O 0.000 description 2
- FFVUAQYOIMKSGF-UHFFFAOYSA-N CC(C1)OC(C)CN1c(nc1C2=NN3c4ccccc4)ccc1NC=C2C3=O Chemical compound CC(C1)OC(C)CN1c(nc1C2=NN3c4ccccc4)ccc1NC=C2C3=O FFVUAQYOIMKSGF-UHFFFAOYSA-N 0.000 description 1
- IRWDLQDHHSWWMJ-UHFFFAOYSA-N CN(CC1)CCN1C1N=C(C(C(C2=O)=CN3)=NN2c2ncccc2)C3=CC1 Chemical compound CN(CC1)CCN1C1N=C(C(C(C2=O)=CN3)=NN2c2ncccc2)C3=CC1 IRWDLQDHHSWWMJ-UHFFFAOYSA-N 0.000 description 1
- OCLHBAOJPIDREO-UHFFFAOYSA-N O=C1N(c2ccccc2)N=C2c(nc(cc3)N4CCCC4)c3NC=C12 Chemical compound O=C1N(c2ccccc2)N=C2c(nc(cc3)N4CCCC4)c3NC=C12 OCLHBAOJPIDREO-UHFFFAOYSA-N 0.000 description 1
- FFXIAKPIQXSHEB-UHFFFAOYSA-N O=C1N(c2ncccc2)N=C2c3nc(N4CCOCC4)ccc3NC=C12 Chemical compound O=C1N(c2ncccc2)N=C2c3nc(N4CCOCC4)ccc3NC=C12 FFXIAKPIQXSHEB-UHFFFAOYSA-N 0.000 description 1
- NYNLFMVQMWMIGX-UHFFFAOYSA-N O=C1[N-](c2ccccc2)[NH+]=C2c3nc(N(CC4)CCN4c4ccccc4)ccc3NC=C12 Chemical compound O=C1[N-](c2ccccc2)[NH+]=C2c3nc(N(CC4)CCN4c4ccccc4)ccc3NC=C12 NYNLFMVQMWMIGX-UHFFFAOYSA-N 0.000 description 1
- YLIZTFTUFLAHDV-UHFFFAOYSA-N OCC(CCC1)CN1c(nc1C2=NN3c4ccccc4)ccc1NC=C2C3=O Chemical compound OCC(CCC1)CN1c(nc1C2=NN3c4ccccc4)ccc1NC=C2C3=O YLIZTFTUFLAHDV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94300007P | 2007-06-08 | 2007-06-08 | |
| US60/943,000 | 2007-06-08 | ||
| PCT/US2008/066211 WO2008154447A1 (en) | 2007-06-08 | 2008-06-06 | Therapeutic pyrazolonaphthyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2689934A1 true CA2689934A1 (en) | 2008-12-18 |
Family
ID=40130166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2689934A Abandoned CA2689934A1 (en) | 2007-06-08 | 2008-06-06 | Therapeutic pyrazolonaphthyridine derivatives |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7858614B2 (enExample) |
| EP (1) | EP2166853B1 (enExample) |
| JP (1) | JP2010529145A (enExample) |
| KR (1) | KR20100036306A (enExample) |
| CN (1) | CN101754681A (enExample) |
| AU (1) | AU2008261803A1 (enExample) |
| BR (1) | BRPI0812369A2 (enExample) |
| CA (1) | CA2689934A1 (enExample) |
| ES (1) | ES2483728T3 (enExample) |
| IL (1) | IL202287A0 (enExample) |
| MX (1) | MX2009013197A (enExample) |
| WO (1) | WO2008154447A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7863266B2 (en) * | 2007-06-08 | 2011-01-04 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline urea derivatives |
| US9012470B2 (en) | 2010-10-14 | 2015-04-21 | Dart Neuroscience (Cayman) Ltd. | Therapeutic 5,6,5-tricyclic analogs |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| US10531200B2 (en) * | 2015-10-23 | 2020-01-07 | Harman International Industries, Incorporated | Dual asymmetric compression driver |
| CN106810550A (zh) * | 2017-01-10 | 2017-06-09 | 湖南华腾制药有限公司 | 一种萘啶衍生物的制备方法 |
| US11485733B2 (en) | 2017-06-30 | 2022-11-01 | Bayer Animal Health Gmbh | Azaquinoline derivatives |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3204126A1 (de) * | 1982-02-06 | 1983-08-11 | Bayer Ag, 5090 Leverkusen | Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4479955A (en) * | 1983-01-10 | 1984-10-30 | Ciba-Geigy Corporation | Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators |
| US4814450A (en) | 1984-07-09 | 1989-03-21 | Ciba-Geigy Corporation | Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives |
| JPS61112075A (ja) * | 1984-11-05 | 1986-05-30 | Shionogi & Co Ltd | チエニルピラゾロキノリン誘導体 |
| EP0214092A1 (en) | 1985-08-08 | 1987-03-11 | Ciba-Geigy Ag | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
| US4817450A (en) * | 1987-11-30 | 1989-04-04 | Spedco, Inc. | Pressure/temperature test plug assembly |
| FR2695126B1 (fr) * | 1992-08-27 | 1994-11-10 | Sanofi Elf | Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant. |
| US5334595A (en) * | 1992-10-23 | 1994-08-02 | Sterling Winthrop Inc. | Pyrazoloquinolones as anticancer agents |
| RU2145606C1 (ru) * | 1994-05-24 | 2000-02-20 | Ф.Хоффманн-Ля Рош Аг | Трициклические дикарбонильные производные и лекарственный препарат на их основе |
| GB9716344D0 (en) * | 1997-08-01 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic compounds |
| GB9716347D0 (en) * | 1997-08-01 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic compounds |
| GB9716345D0 (en) * | 1997-08-01 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic compounds |
| TWI271406B (en) * | 1999-12-13 | 2007-01-21 | Eisai Co Ltd | Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same |
| GB0108475D0 (en) * | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
| JP3896309B2 (ja) * | 2001-07-09 | 2007-03-22 | ファイザー株式会社 | プロテインキナーゼｃ阻害物質としてのピラゾロキノリノン誘導体 |
| ATE425164T1 (de) * | 2002-12-16 | 2009-03-15 | Active Biotech Ab | Tetrazyklische immunmodulierende verbindungen |
| AR045689A1 (es) * | 2003-05-29 | 2005-11-09 | Millennium Pharm Inc | Compuestos derivados de 2,5-dihidro-pirazolo[4,3-c]quinolin-4-ona como inhibidores de chk-1 y composiciones farmaceuticas que los contienen |
| US7544697B2 (en) * | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| CN1893943A (zh) * | 2003-10-03 | 2007-01-10 | 3M创新有限公司 | 吡唑并吡啶和其类似物 |
| AU2006287378A1 (en) * | 2005-09-07 | 2007-03-15 | Braincells, Inc. | Modulation of neurogenesis by HDac inhibition |
| ES2386168T3 (es) * | 2007-06-08 | 2012-08-10 | Helicon Therapeutics, Inc. | Derivados de pirazoloquinolina terapéuticos |
-
2008
- 2008-06-06 ES ES08770412.8T patent/ES2483728T3/es active Active
- 2008-06-06 US US12/135,045 patent/US7858614B2/en not_active Expired - Fee Related
- 2008-06-06 JP JP2010511393A patent/JP2010529145A/ja active Pending
- 2008-06-06 CA CA2689934A patent/CA2689934A1/en not_active Abandoned
- 2008-06-06 MX MX2009013197A patent/MX2009013197A/es active IP Right Grant
- 2008-06-06 BR BRPI0812369A patent/BRPI0812369A2/pt not_active IP Right Cessation
- 2008-06-06 KR KR1020107000331A patent/KR20100036306A/ko not_active Withdrawn
- 2008-06-06 AU AU2008261803A patent/AU2008261803A1/en not_active Abandoned
- 2008-06-06 CN CN200880025152A patent/CN101754681A/zh active Pending
- 2008-06-06 EP EP08770412.8A patent/EP2166853B1/en not_active Not-in-force
- 2008-06-06 WO PCT/US2008/066211 patent/WO2008154447A1/en not_active Ceased
-
2009
- 2009-11-23 IL IL202287A patent/IL202287A0/en unknown
-
2010
- 2010-11-18 US US12/949,619 patent/US8497262B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1142774A1 (en) | 2010-12-17 |
| EP2166853B1 (en) | 2014-05-28 |
| EP2166853A4 (en) | 2011-04-06 |
| CN101754681A (zh) | 2010-06-23 |
| MX2009013197A (es) | 2010-04-27 |
| KR20100036306A (ko) | 2010-04-07 |
| US20110065692A1 (en) | 2011-03-17 |
| AU2008261803A1 (en) | 2008-12-18 |
| WO2008154447A1 (en) | 2008-12-18 |
| EP2166853A1 (en) | 2010-03-31 |
| BRPI0812369A2 (pt) | 2016-08-09 |
| JP2010529145A (ja) | 2010-08-26 |
| US8497262B2 (en) | 2013-07-30 |
| ES2483728T3 (es) | 2014-08-07 |
| IL202287A0 (en) | 2010-06-16 |
| US20090005365A1 (en) | 2009-01-01 |
| US7858614B2 (en) | 2010-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8343957B2 (en) | Therapeutic pyrazoloquinoline urea derivatives | |
| EP2166853B1 (en) | Therapeutic pyrazolonaphthyridine derivatives | |
| US8598159B2 (en) | Therapeutic pyrazoloquinoline derivatives | |
| JP2010529145A5 (enExample) | ||
| HK1142774B (en) | Therapeutic pyrazolonaphthyridine derivatives | |
| US9012470B2 (en) | Therapeutic 5,6,5-tricyclic analogs | |
| HK1142775B (en) | Therapeutic pyrazoloquinoline derivatives | |
| HK1144892A (en) | Therapeutic pyrazolonaphthyridine derivatives | |
| HK1142496B (en) | Therapeutic pyrazoloquinoline urea derivatives | |
| HK1144891A (zh) | 治疗用吡唑并喹啉衍生物 | |
| HK1142776A (en) | Therapeutic pyrazoloquinoline urea derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140606 |