AU2007339762B2 - Compositions and methods for treating inflammation and auto-immune diseases - Google Patents
Compositions and methods for treating inflammation and auto-immune diseases Download PDFInfo
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- AU2007339762B2 AU2007339762B2 AU2007339762A AU2007339762A AU2007339762B2 AU 2007339762 B2 AU2007339762 B2 AU 2007339762B2 AU 2007339762 A AU2007339762 A AU 2007339762A AU 2007339762 A AU2007339762 A AU 2007339762A AU 2007339762 B2 AU2007339762 B2 AU 2007339762B2
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7989173B2 (en) * | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
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| US20130068691A1 (en) * | 2011-08-05 | 2013-03-21 | Henry John Smith | Targeted apheresis for the treatment of rheumatoid arthritis and immune disorders |
| WO2013025779A1 (en) | 2011-08-15 | 2013-02-21 | Amplimmune, Inc. | Anti-b7-h4 antibodies and their uses |
| CA2894689A1 (en) * | 2012-12-19 | 2014-06-26 | Amplimmune, Inc. | Anti-human b7-h4 antibodies and their uses |
| US20160146806A1 (en) | 2013-05-17 | 2016-05-26 | Amplimmune, Inc. | Receptors for b7-h4 |
| WO2014194293A1 (en) | 2013-05-30 | 2014-12-04 | Amplimmune, Inc. | Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof |
| CA2978942A1 (en) | 2015-03-13 | 2016-09-22 | Cytomx Therapeutics, Inc. | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
| CA3004138A1 (en) | 2015-11-03 | 2017-05-11 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and tim-3 and their uses |
| KR20200016899A (ko) | 2017-06-01 | 2020-02-17 | 싸이톰스 테라퓨틱스, 인크. | 활성화가능 항-pdl1 항체, 및 이의 이용 방법 |
| PE20200797A1 (es) | 2017-08-25 | 2020-08-10 | Five Prime Therapeutics Inc | Anticuerpos que se unen especificamente a b7-h4 humana |
| US12398209B2 (en) | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
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| CA3203721A1 (en) | 2021-01-04 | 2022-07-07 | Timothy B. Lowinger | B7h4-targeted antibody-drug conjugates and methods of use thereof |
Family Cites Families (115)
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| US5155020A (en) * | 1989-03-08 | 1992-10-13 | Health Research Inc. | Recombinant poxvirus host range selection system |
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| US4634666A (en) * | 1984-01-06 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Human-murine hybridoma fusion partner |
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| US5260203A (en) * | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4704692A (en) * | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| EP0279582A3 (en) * | 1987-02-17 | 1989-10-18 | Pharming B.V. | Dna sequences to target proteins to the mammary gland for efficient secretion |
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| US4980289A (en) * | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| US4861627A (en) * | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
| US5278056A (en) * | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| US4891719A (en) * | 1988-10-03 | 1990-01-02 | Datatape Incorporated | Fast closure method for a data signal channel |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5124263A (en) * | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
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| US5175099A (en) * | 1989-05-17 | 1992-12-29 | Research Corporation Technologies, Inc. | Retrovirus-mediated secretion of recombinant products |
| US5240846A (en) | 1989-08-22 | 1993-08-31 | The Regents Of The University Of Michigan | Gene therapy vector for cystic fibrosis |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| ATE356869T1 (de) | 1990-01-12 | 2007-04-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
| US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US5204243A (en) * | 1990-02-14 | 1993-04-20 | Health Research Incorporated | Recombinant poxvirus internal cores |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| CA2089661C (en) * | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5877397A (en) * | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5874299A (en) * | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5814318A (en) * | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5789650A (en) * | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| AU643141B2 (en) * | 1991-03-15 | 1993-11-04 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| DE69230142T2 (de) * | 1991-05-15 | 2000-03-09 | Cambridge Antibody Technology Ltd. | Verfahren zur herstellung von spezifischen bindungspaargliedern |
| US5858657A (en) * | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5120727A (en) * | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Rapamycin dimers |
| KR0163798B1 (ko) | 1991-07-03 | 1999-01-15 | 나가따 마사오 | 열가성 폴리우레탄 탄성체, 그의 제조 방법, 그의 제조 장치 및 그로부터 제조한 탄성 섬유 |
| US5202332A (en) | 1991-08-07 | 1993-04-13 | American Home Products Corporation | Rapamycin analog as immunosuppressant |
| US5162333A (en) * | 1991-09-11 | 1992-11-10 | American Home Products Corporation | Aminodiesters of rapamycin |
| US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5932448A (en) * | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| US5733743A (en) * | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| PT633783E (pt) * | 1992-03-30 | 2000-11-30 | American Home Prod | Formulacao de rapamicina para injeccao intravenosa |
| US5489680A (en) * | 1992-10-13 | 1996-02-06 | American Home Products Corporation | Carbamates of rapamycin |
| US5434260A (en) | 1992-10-13 | 1995-07-18 | American Home Products Corporation | Carbamates of rapamycin |
| ATE199392T1 (de) * | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| DE4301681C1 (de) * | 1993-01-22 | 1994-10-20 | Deutsche Aerospace Airbus | Rohrverzweigung zwischen einer Luftleitung und einer Luftdusche |
| US5387680A (en) | 1993-08-10 | 1995-02-07 | American Home Products Corporation | C-22 ring stabilized rapamycin derivatives |
| EP0735893B1 (en) * | 1993-09-14 | 2008-11-26 | Pharmexa Inc. | Pan dr-binding peptides for enhancement of the immune response |
| AU689153B2 (en) | 1993-11-08 | 1998-03-26 | Cressy, Wayne Malcolm | Head restraining device |
| US5385908A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Hindered esters of rapamycin |
| ES2146741T3 (es) | 1993-12-17 | 2000-08-16 | Novartis Ag | Derivados de rapamicina utiles como inmunosupresores. |
| US5827690A (en) * | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5877218A (en) * | 1994-01-10 | 1999-03-02 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| US5362735A (en) | 1994-02-23 | 1994-11-08 | Smithkline Beecham Corporation | Rapamycin derivatives |
| US5451569A (en) * | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| AU705688B2 (en) | 1995-11-10 | 1999-05-27 | Cytogen Corporation | Peptides which enhance transport across tissues and methods of identifying and using the same |
| US5780462A (en) | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| EP0793995B1 (en) * | 1996-03-05 | 2001-10-04 | Hitachi, Ltd. | Method of treating gases containing organohalogen compounds |
| WO1999063088A2 (en) | 1998-06-02 | 1999-12-09 | Genentech, Inc. | Membrane-bound proteins and nucleic acids encoding the same |
| AUPO390396A0 (en) | 1996-11-29 | 1996-12-19 | Csl Limited | Novel promiscuous T helper cell epitopes |
| US5989591A (en) * | 1997-03-14 | 1999-11-23 | American Home Products Corporation | Rapamycin formulations for oral administration |
| US6982323B1 (en) * | 1997-12-23 | 2006-01-03 | Alexion Pharmaceuticals, Inc. | Chimeric proteins for diagnosis and treatment of diabetes |
| GB9814640D0 (en) | 1998-07-06 | 1998-09-02 | Fujisawa Pharmaceutical Co | New use |
| US6015809A (en) | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
| ES2317704T3 (es) | 1998-09-02 | 2009-04-16 | Diadexus, Inc. | Un nuevo metodo para el diagnostico, seguimiento, estadificacion. imagineria y tratamiento de distintos canceres. |
| US6468546B1 (en) | 1998-12-17 | 2002-10-22 | Corixa Corporation | Compositions and methods for therapy and diagnosis of ovarian cancer |
| US6962980B2 (en) * | 1999-09-24 | 2005-11-08 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
| US7232889B2 (en) * | 1999-03-08 | 2007-06-19 | Genentech, Inc. | PRO300 antibodies |
| AU6058500A (en) * | 1999-06-30 | 2001-01-31 | Center For Blood Research, The | Fusion protein and uses thereof |
| DE19937656A1 (de) * | 1999-08-13 | 2001-02-15 | Aventis Behring Gmbh | Verwendung von Antithrombin III zur Prophylaxe und Therapie von Erkrankungen |
| MXPA02012749A (es) * | 2000-06-30 | 2003-10-06 | Amgen Inc | Moleculas semejantes a b7 y sus usos. |
| US6537968B1 (en) * | 2000-07-24 | 2003-03-25 | Alphamed Pharmaceuticals Corp | Treatment of lupus erythematosus |
| AU2001283507A1 (en) * | 2000-07-27 | 2002-02-13 | Mayo Foundation For Medical Education And Research | B7-h3 and b7-h4, novel immunoregulatory molecules |
| US7975021B2 (en) * | 2000-10-23 | 2011-07-05 | Clearplay, Inc. | Method and user interface for downloading audio and video content filters to a media player |
| US6562576B2 (en) * | 2001-01-04 | 2003-05-13 | Myriad Genetics, Inc. | Yeast two-hybrid system and use thereof |
| CN100488563C (zh) * | 2001-02-19 | 2009-05-20 | 默克专利有限公司 | 免疫原性降低的经修饰抗egfr抗体 |
| US20050215727A1 (en) * | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
| IL150013A (en) * | 2002-06-04 | 2007-06-17 | Gil Hecht | Swivel cutting tool |
| EP1539218A4 (en) * | 2002-06-20 | 2007-08-22 | Univ California | COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY |
| WO2004022594A2 (en) * | 2002-09-06 | 2004-03-18 | Cytos Biotechnology Ag | Immune modulatory compounds and methods |
| US7449300B2 (en) * | 2002-11-21 | 2008-11-11 | Mayo Foundation For Medical Education And Research | Detection of antibodies specific for B7-H1 in subjects with diseases or pathological conditions mediated by activated T cells |
| WO2004113500A2 (en) * | 2003-06-16 | 2004-12-29 | The University Of Washington | B7s1: an immune modulator |
| US7334413B2 (en) * | 2004-05-07 | 2008-02-26 | Rosemount Aerospace Inc. | Apparatus, system and method for observing combustion conditions in a gas turbine engine |
| DE102004060403A1 (de) * | 2004-12-14 | 2006-07-06 | Trützschler GmbH & Co KG | Vorrichtung in der Spinnereivorbereitung zur Speisung einer Mehrzahl von Füllschächten, insbesondere Mischer, mit Fasermaterial |
| US7694100B2 (en) * | 2004-12-20 | 2010-04-06 | Intel Corporation | Managing system memory resident device management queues |
| WO2006101692A1 (en) * | 2005-03-23 | 2006-09-28 | Pfizer Products Inc. | Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer |
| BRPI0611766A2 (pt) * | 2005-06-08 | 2011-12-20 | Dana Farber Cancer Inst Inc | métodos e composições para o tratamento de infecções persistentes e cáncer por inibição da rota de morte celular programada |
| US20070039150A1 (en) * | 2005-08-08 | 2007-02-22 | Thomas David L | Convertible furniture system comprised of modular convertible box frames and methods of forming various furniture configurations therefrom |
| KR100779170B1 (ko) * | 2005-08-16 | 2007-11-23 | 학교법인 포항공과대학교 | 광양자테 홀 발광소자의 버트 커플링 방법 |
| JP4730263B2 (ja) * | 2005-09-21 | 2011-07-20 | 富士ゼロックス株式会社 | 画像処理装置の保守システム |
| US8241621B2 (en) * | 2006-12-18 | 2012-08-14 | Medistem Laboratories | Stem cell mediated treg activation/expansion for therapeutic immune modulation |
| US7989173B2 (en) * | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
| US20080206235A1 (en) * | 2006-12-27 | 2008-08-28 | Johns Hopkins University | Compositions and methods for stimulating an immune response |
| US20090142342A1 (en) * | 2006-12-27 | 2009-06-04 | Johns Hopkins University | B7-h4 receptor agonist compositions and methods for treating inflammation and auto-immune diseases |
| CN101399708B (zh) * | 2007-09-28 | 2012-04-04 | 华为技术有限公司 | 一种建立网络性能模型的方法和设备 |
| US20090124573A1 (en) * | 2007-11-09 | 2009-05-14 | Sarkis Mazmanian | Immunomodulating compounds and related compositions and methods |
| AU2010286351A1 (en) * | 2009-08-31 | 2012-03-15 | Amplimmune, Inc. | B7-H4 fusion proteins and methods of use thereof |
-
2007
- 2007-12-27 US US11/965,611 patent/US20080206235A1/en not_active Abandoned
- 2007-12-27 WO PCT/US2007/088960 patent/WO2008083228A2/en not_active Ceased
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- 2007-12-27 EP EP12192744.6A patent/EP2586458B1/en not_active Not-in-force
- 2007-12-27 CA CA002673659A patent/CA2673659A1/en not_active Abandoned
- 2007-12-27 CA CA002673752A patent/CA2673752A1/en not_active Abandoned
- 2007-12-27 AU AU2007339762A patent/AU2007339762B2/en not_active Ceased
- 2007-12-27 JP JP2009544272A patent/JP2011502954A/ja active Pending
- 2007-12-27 EP EP20070866065 patent/EP2124998B8/en not_active Not-in-force
- 2007-12-27 EP EP07869990A patent/EP2109455A2/en not_active Withdrawn
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-
2010
- 2010-10-15 US US12/905,796 patent/US20110195073A1/en not_active Abandoned
-
2011
- 2011-03-23 US US13/070,139 patent/US20110171207A1/en not_active Abandoned
-
2013
- 2013-05-16 JP JP2013103888A patent/JP5926701B2/ja not_active Expired - Fee Related
-
2015
- 2015-11-25 JP JP2015229316A patent/JP2016035474A/ja not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| Choi, IH et al., J Immunol, 2003, Vol.171, pages 4650-4654 * |
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| US20080160036A1 (en) | 2008-07-03 |
| JP5481199B2 (ja) | 2014-04-23 |
| EP2109455A2 (en) | 2009-10-21 |
| JP2013155199A (ja) | 2013-08-15 |
| HK1184697A1 (en) | 2014-01-30 |
| US20110171207A1 (en) | 2011-07-14 |
| CA2673659A1 (en) | 2008-07-10 |
| US20080206235A1 (en) | 2008-08-28 |
| EP2124998B1 (en) | 2015-02-18 |
| WO2008083239A3 (en) | 2008-08-28 |
| AU2007339773A1 (en) | 2008-07-10 |
| US20110195073A1 (en) | 2011-08-11 |
| JP2010530354A (ja) | 2010-09-09 |
| WO2008083228A2 (en) | 2008-07-10 |
| EP2124998A2 (en) | 2009-12-02 |
| JP2016035474A (ja) | 2016-03-17 |
| AU2007339762A1 (en) | 2008-07-10 |
| US7931896B2 (en) | 2011-04-26 |
| HK1139070A1 (en) | 2010-09-10 |
| EP2586458A1 (en) | 2013-05-01 |
| CA2673752A1 (en) | 2008-07-10 |
| WO2008083228A3 (en) | 2008-11-06 |
| JP5926701B2 (ja) | 2016-05-25 |
| EP2586458B1 (en) | 2016-08-24 |
| EP2124998B8 (en) | 2015-05-06 |
| JP2011502954A (ja) | 2011-01-27 |
| WO2008083239A2 (en) | 2008-07-10 |
| AU2007339773B2 (en) | 2011-03-10 |
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