AU2007272781B2 - Combi) compositions for the treatment of mucormycosis. comprising iron chelator and antifungal agent - Google Patents
Combi) compositions for the treatment of mucormycosis. comprising iron chelator and antifungal agent Download PDFInfo
- Publication number
- AU2007272781B2 AU2007272781B2 AU2007272781A AU2007272781A AU2007272781B2 AU 2007272781 B2 AU2007272781 B2 AU 2007272781B2 AU 2007272781 A AU2007272781 A AU 2007272781A AU 2007272781 A AU2007272781 A AU 2007272781A AU 2007272781 B2 AU2007272781 B2 AU 2007272781B2
- Authority
- AU
- Australia
- Prior art keywords
- mucormycosis
- iron
- antifungal agent
- deferasirox
- iron chelating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 229940121375 antifungal agent Drugs 0.000 title claims abstract description 128
- 239000003429 antifungal agent Substances 0.000 title claims abstract description 113
- 239000000203 mixture Substances 0.000 title claims abstract description 103
- 206010061418 Zygomycosis Diseases 0.000 title claims description 117
- 201000007524 mucormycosis Diseases 0.000 title claims description 116
- 238000011282 treatment Methods 0.000 title description 56
- OEUUFNIKLCFNLN-LLVKDONJSA-N chembl432481 Chemical compound OC(=O)[C@@]1(C)CSC(C=2C(=CC(O)=CC=2)O)=N1 OEUUFNIKLCFNLN-LLVKDONJSA-N 0.000 title description 20
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 359
- 229910052742 iron Inorganic materials 0.000 claims abstract description 174
- 229960001489 deferasirox Drugs 0.000 claims abstract description 172
- FMSOAWSKCWYLBB-VBGLAJCLSA-N deferasirox Chemical compound C1=CC(C(=O)O)=CC=C1N(N\C(N\1)=C\2C(C=CC=C/2)=O)C/1=C\1C(=O)C=CC=C/1 FMSOAWSKCWYLBB-VBGLAJCLSA-N 0.000 claims abstract description 172
- 239000000797 iron chelating agent Substances 0.000 claims abstract description 69
- TZXKOCQBRNJULO-UHFFFAOYSA-N Ferriprox Chemical compound CC1=C(O)C(=O)C=CN1C TZXKOCQBRNJULO-UHFFFAOYSA-N 0.000 claims abstract description 64
- 238000000034 method Methods 0.000 claims abstract description 61
- 229960003266 deferiprone Drugs 0.000 claims abstract description 59
- 150000001875 compounds Chemical class 0.000 claims abstract description 50
- 239000000589 Siderophore Substances 0.000 claims abstract description 33
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims abstract description 26
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims abstract description 25
- 150000004291 polyenes Chemical class 0.000 claims abstract description 16
- 108010049047 Echinocandins Proteins 0.000 claims abstract description 13
- 230000000069 prophylactic effect Effects 0.000 claims abstract description 5
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical group O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims description 123
- 240000005384 Rhizopus oryzae Species 0.000 claims description 93
- 210000003734 kidney Anatomy 0.000 claims description 21
- 230000000843 anti-fungal effect Effects 0.000 claims description 18
- 241000235388 Mucorales Species 0.000 claims description 17
- -1 voricoazole Chemical compound 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 108010020326 Caspofungin Proteins 0.000 claims description 9
- 241000235527 Rhizopus Species 0.000 claims description 9
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 8
- 108010021062 Micafungin Proteins 0.000 claims description 8
- 235000013752 Rhizopus oryzae Nutrition 0.000 claims description 8
- 229960000730 caspofungin acetate Drugs 0.000 claims description 8
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 claims description 8
- 229960004884 fluconazole Drugs 0.000 claims description 8
- 229960004130 itraconazole Drugs 0.000 claims description 8
- 229960002159 micafungin Drugs 0.000 claims description 8
- PIEUQSKUWLMALL-YABMTYFHSA-N micafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@H](O)CC(N)=O)[C@H](O)[C@@H](O)C=2C=C(OS(O)(=O)=O)C(O)=CC=2)[C@@H](C)O)=O)=NO1 PIEUQSKUWLMALL-YABMTYFHSA-N 0.000 claims description 8
- 229960001589 posaconazole Drugs 0.000 claims description 8
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical group O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims description 8
- OGUJBRYAAJYXQP-IJFZAWIJSA-N vuw370o5qe Chemical group CC(O)=O.CC(O)=O.C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 OGUJBRYAAJYXQP-IJFZAWIJSA-N 0.000 claims description 8
- 210000000988 bone and bone Anatomy 0.000 claims description 7
- 241000235395 Mucor Species 0.000 claims description 6
- 230000002685 pulmonary effect Effects 0.000 claims description 6
- 241000235555 Cunninghamella Species 0.000 claims description 3
- 241000235554 Cunninghamellaceae Species 0.000 claims description 3
- 241000293034 Apophysomyces elegans Species 0.000 claims description 2
- 241000144128 Lichtheimia corymbifera Species 0.000 claims description 2
- 241000235525 Rhizomucor pusillus Species 0.000 claims description 2
- 241000293024 Rhizopus microsporus var. rhizopodiformis Species 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 210000001370 mediastinum Anatomy 0.000 claims description 2
- 206010033072 otitis externa Diseases 0.000 claims description 2
- 210000004303 peritoneum Anatomy 0.000 claims description 2
- 210000003437 trachea Anatomy 0.000 claims description 2
- 210000002620 vena cava superior Anatomy 0.000 claims description 2
- 239000012678 infectious agent Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 abstract description 93
- 241000699670 Mus sp. Species 0.000 description 104
- 208000015181 infectious disease Diseases 0.000 description 64
- 239000000902 placebo Substances 0.000 description 47
- 229940068196 placebo Drugs 0.000 description 47
- 230000004083 survival effect Effects 0.000 description 37
- 238000009472 formulation Methods 0.000 description 36
- 241000233866 Fungi Species 0.000 description 29
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 28
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 28
- 238000002560 therapeutic procedure Methods 0.000 description 28
- 210000000056 organ Anatomy 0.000 description 27
- 206010012601 diabetes mellitus Diseases 0.000 description 26
- 230000009920 chelation Effects 0.000 description 25
- 230000000694 effects Effects 0.000 description 25
- 230000012010 growth Effects 0.000 description 22
- 229960000958 deferoxamine Drugs 0.000 description 21
- 208000024891 symptom Diseases 0.000 description 21
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 description 20
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 19
- 210000004556 brain Anatomy 0.000 description 19
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 18
- 239000002738 chelating agent Substances 0.000 description 18
- 239000005090 green fluorescent protein Substances 0.000 description 18
- 208000031888 Mycoses Diseases 0.000 description 17
- 239000003814 drug Substances 0.000 description 16
- 210000001519 tissue Anatomy 0.000 description 16
- 210000002966 serum Anatomy 0.000 description 15
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 14
- 238000002655 chelation therapy Methods 0.000 description 14
- 230000002354 daily effect Effects 0.000 description 14
- 229940079593 drug Drugs 0.000 description 14
- 229940024583 exjade Drugs 0.000 description 14
- 230000014509 gene expression Effects 0.000 description 14
- 206010017533 Fungal infection Diseases 0.000 description 13
- 238000009738 saturating Methods 0.000 description 13
- BOFQWVMAQOTZIW-UHFFFAOYSA-N deferasirox Chemical compound C1=CC(C(=O)O)=CC=C1N1C(C=2C(=CC=CC=2)O)=NC(C=2C(=CC=CC=2)O)=N1 BOFQWVMAQOTZIW-UHFFFAOYSA-N 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 239000001965 potato dextrose agar Substances 0.000 description 12
- 241000894007 species Species 0.000 description 12
- 230000001225 therapeutic effect Effects 0.000 description 12
- 241000257015 Rhizopus oryzae 99-892 Species 0.000 description 11
- 241000222122 Candida albicans Species 0.000 description 10
- 108090000695 Cytokines Proteins 0.000 description 10
- 102000004127 Cytokines Human genes 0.000 description 10
- 206010037660 Pyrexia Diseases 0.000 description 10
- 230000001684 chronic effect Effects 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 9
- 241000699666 Mus <mouse, genus> Species 0.000 description 9
- 201000003984 candidiasis Diseases 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 238000000338 in vitro Methods 0.000 description 9
- 238000001727 in vivo Methods 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 8
- 206010007134 Candida infections Diseases 0.000 description 8
- 229960003942 amphotericin b Drugs 0.000 description 8
- 238000002648 combination therapy Methods 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 8
- 230000003902 lesion Effects 0.000 description 8
- 210000004698 lymphocyte Anatomy 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 230000003393 splenic effect Effects 0.000 description 8
- 239000004094 surface-active agent Substances 0.000 description 8
- 201000002909 Aspergillosis Diseases 0.000 description 7
- 241000228212 Aspergillus Species 0.000 description 7
- 208000036641 Aspergillus infections Diseases 0.000 description 7
- 208000035473 Communicable disease Diseases 0.000 description 7
- 201000007336 Cryptococcosis Diseases 0.000 description 7
- 206010061598 Immunodeficiency Diseases 0.000 description 7
- 239000000470 constituent Substances 0.000 description 7
- 230000034994 death Effects 0.000 description 7
- 238000010172 mouse model Methods 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 229940035893 uracil Drugs 0.000 description 7
- 230000001018 virulence Effects 0.000 description 7
- 206010005098 Blastomycosis Diseases 0.000 description 6
- 241000221204 Cryptococcus neoformans Species 0.000 description 6
- 208000001380 Diabetic Ketoacidosis Diseases 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000010171 animal model Methods 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 210000001185 bone marrow Anatomy 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 206010040882 skin lesion Diseases 0.000 description 6
- 231100000444 skin lesion Toxicity 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 210000003462 vein Anatomy 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 208000004770 Fusariosis Diseases 0.000 description 5
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 5
- 201000002563 Histoplasmosis Diseases 0.000 description 5
- 206010036790 Productive cough Diseases 0.000 description 5
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 239000008121 dextrose Substances 0.000 description 5
- 244000053095 fungal pathogen Species 0.000 description 5
- 230000002757 inflammatory effect Effects 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 238000001325 log-rank test Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 230000008506 pathogenesis Effects 0.000 description 5
- 230000001575 pathological effect Effects 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 230000000750 progressive effect Effects 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 230000002441 reversible effect Effects 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 5
- 229960001052 streptozocin Drugs 0.000 description 5
- 230000008685 targeting Effects 0.000 description 5
- 230000035899 viability Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- UUDALWDRIFYZPM-UHFFFAOYSA-N 1h-pyridine-2,4-dione Chemical compound O=C1CC(=O)C=CN1 UUDALWDRIFYZPM-UHFFFAOYSA-N 0.000 description 4
- 208000030507 AIDS Diseases 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 4
- 206010065973 Iron Overload Diseases 0.000 description 4
- 108090000301 Membrane transport proteins Proteins 0.000 description 4
- 241001480490 Mucoraceae Species 0.000 description 4
- 241001529936 Murinae Species 0.000 description 4
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 208000001388 Opportunistic Infections Diseases 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 230000000692 anti-sense effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 229940095731 candida albicans Drugs 0.000 description 4
- 239000013522 chelant Substances 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 238000000684 flow cytometry Methods 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 230000002458 infectious effect Effects 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 210000000440 neutrophil Anatomy 0.000 description 4
- 229960003330 pentetic acid Drugs 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 229920005646 polycarboxylate Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- 229930183010 Amphotericin Natural products 0.000 description 3
- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 description 3
- 241001225321 Aspergillus fumigatus Species 0.000 description 3
- 241000700198 Cavia Species 0.000 description 3
- 206010008479 Chest Pain Diseases 0.000 description 3
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 3
- 241000235577 Entomophthorales Species 0.000 description 3
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 3
- 206010022004 Influenza like illness Diseases 0.000 description 3
- 208000007976 Ketosis Diseases 0.000 description 3
- 208000000112 Myalgia Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 241000952054 Rhizopus sp. Species 0.000 description 3
- 206010041736 Sporotrichosis Diseases 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 108010004469 allophycocyanin Proteins 0.000 description 3
- 229940009444 amphotericin Drugs 0.000 description 3
- 229940091771 aspergillus fumigatus Drugs 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 238000002591 computed tomography Methods 0.000 description 3
- 238000004624 confocal microscopy Methods 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000003246 corticosteroid Substances 0.000 description 3
- 210000003792 cranial nerve Anatomy 0.000 description 3
- 229960004397 cyclophosphamide Drugs 0.000 description 3
- 238000001804 debridement Methods 0.000 description 3
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000000855 fungicidal effect Effects 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 230000004941 influx Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 3
- 238000007449 liver function test Methods 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 241001515942 marmosets Species 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 208000004235 neutropenia Diseases 0.000 description 3
- 238000003305 oral gavage Methods 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 238000011321 prophylaxis Methods 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 238000009118 salvage therapy Methods 0.000 description 3
- 238000009097 single-agent therapy Methods 0.000 description 3
- 201000009890 sinusitis Diseases 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 210000004988 splenocyte Anatomy 0.000 description 3
- 210000003802 sputum Anatomy 0.000 description 3
- 208000024794 sputum Diseases 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 238000011269 treatment regimen Methods 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- KUYCNLUJQMRORQ-IYBDPMFKSA-N (2r)-2-[2-[4-[[(3s)-3,4-dicarboxy-3-hydroxybutanoyl]amino]butylamino]-2-oxoethyl]-2-hydroxybutanedioic acid Chemical compound OC(=O)C[C@@](O)(C(O)=O)CC(=O)NCCCCNC(=O)C[C@@](O)(C(O)=O)CC(O)=O KUYCNLUJQMRORQ-IYBDPMFKSA-N 0.000 description 2
- 108020004463 18S ribosomal RNA Proteins 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 2
- HRBYEPVOFCWVAZ-UHFFFAOYSA-N 3-(2H-triazol-4-yl)benzene-1,2-diol Chemical class Oc1cccc(-c2c[nH]nn2)c1O HRBYEPVOFCWVAZ-UHFFFAOYSA-N 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 208000004020 Brain Abscess Diseases 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 241000223205 Coccidioides immitis Species 0.000 description 2
- 208000006081 Cryptococcal meningitis Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 2
- 206010017523 Fungaemia Diseases 0.000 description 2
- WRFIKQWBKYAFNH-UHFFFAOYSA-N Fusarinine Natural products CC(=C/C(=O)N(O)CCCC(N)C(=O)O)CCO WRFIKQWBKYAFNH-UHFFFAOYSA-N 0.000 description 2
- 229940126656 GS-4224 Drugs 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010018473 Glycosuria Diseases 0.000 description 2
- 206010020144 Histoplasmosis disseminated Diseases 0.000 description 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 2
- 208000003539 Hyalohyphomycosis Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 2
- 102000008133 Iron-Binding Proteins Human genes 0.000 description 2
- 108010035210 Iron-Binding Proteins Proteins 0.000 description 2
- 206010023388 Ketonuria Diseases 0.000 description 2
- 208000019693 Lung disease Diseases 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010027209 Meningitis cryptococcal Diseases 0.000 description 2
- 206010029155 Nephropathy toxic Diseases 0.000 description 2
- 201000000301 Paracoccidioidomycosis Diseases 0.000 description 2
- 206010064458 Penicilliosis Diseases 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- ATRYXFRWRWMFLK-UHFFFAOYSA-N Rhizoferrin Natural products OC(CC(=O)NCCCCNC(=O)CC(O)C(C(=O)O)C(=O)O)C(C(=O)O)C(=O)O ATRYXFRWRWMFLK-UHFFFAOYSA-N 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 102000004338 Transferrin Human genes 0.000 description 2
- 108090000901 Transferrin Proteins 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000007950 acidosis Effects 0.000 description 2
- 208000026545 acidosis disease Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000011360 adjunctive therapy Methods 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- PGAZAORSURCSOS-UHFFFAOYSA-N benzene-1,2-diol;phenol Chemical class OC1=CC=CC=C1.OC1=CC=CC=C1O PGAZAORSURCSOS-UHFFFAOYSA-N 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 238000009640 blood culture Methods 0.000 description 2
- 210000000133 brain stem Anatomy 0.000 description 2
- 201000007262 cavernous sinus thrombosis Diseases 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 239000007979 citrate buffer Substances 0.000 description 2
- 201000003486 coccidioidomycosis Diseases 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 230000003292 diminished effect Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 238000004362 fungal culture Methods 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 230000005745 host immune response Effects 0.000 description 2
- 235000003642 hunger Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 201000009085 invasive aspergillosis Diseases 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 210000002418 meninge Anatomy 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 231100000417 nephrotoxicity Toxicity 0.000 description 2
- 230000007694 nephrotoxicity Effects 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 231100000956 nontoxicity Toxicity 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 229930000184 phytotoxin Natural products 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000000770 proinflammatory effect Effects 0.000 description 2
- 101150116440 pyrF gene Proteins 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000003289 regulatory T cell Anatomy 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- PUWVNTVQJFSBDH-RYUDHWBXSA-N rhodotorulic acid Chemical compound CC(=O)N(O)CCC[C@@H]1NC(=O)[C@H](CCCN(O)C(C)=O)NC1=O PUWVNTVQJFSBDH-RYUDHWBXSA-N 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 230000000995 siderophoric effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000037351 starvation Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000007675 toxicity by organ Effects 0.000 description 2
- 239000012581 transferrin Substances 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- 208000016261 weight loss Diseases 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- WZUVPPKBWHMQCE-XJKSGUPXSA-N (+)-haematoxylin Chemical compound C12=CC(O)=C(O)C=C2C[C@]2(O)[C@H]1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-XJKSGUPXSA-N 0.000 description 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- PUWVNTVQJFSBDH-UHFFFAOYSA-N (2S-cis)-N,N'-[(3,6-dioxopiperazine-2,5-diyl)di-3,1-propanediyl]bis[N-hydroxyacetamide] Natural products CC(=O)N(O)CCCC1NC(=O)C(CCCN(O)C(C)=O)NC1=O PUWVNTVQJFSBDH-UHFFFAOYSA-N 0.000 description 1
- MKDKGLNKTMDNHY-WXUKJITCSA-N (e)-n,5-dihydroxy-n-[3-[5-[3-[hydroxy-[(e)-5-hydroxy-3-methylpent-2-enoyl]amino]propyl]-3,6-dioxopiperazin-2-yl]propyl]-3-methylpent-2-enamide Chemical compound OCCC(/C)=C/C(=O)N(O)CCCC1NC(=O)C(CCCN(O)C(=O)\C=C(/C)CCO)NC1=O MKDKGLNKTMDNHY-WXUKJITCSA-N 0.000 description 1
- 125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 description 1
- TWCHHJPRJFGLNE-UHFFFAOYSA-N 2-hydroxy-2h-pyridin-3-one Chemical class OC1N=CC=CC1=O TWCHHJPRJFGLNE-UHFFFAOYSA-N 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241001439211 Almeida Species 0.000 description 1
- 102000000412 Annexin Human genes 0.000 description 1
- 108050008874 Annexin Proteins 0.000 description 1
- 241000228193 Aspergillus clavatus Species 0.000 description 1
- 241000228197 Aspergillus flavus Species 0.000 description 1
- 241000351920 Aspergillus nidulans Species 0.000 description 1
- 241000228257 Aspergillus sp. Species 0.000 description 1
- 241001465318 Aspergillus terreus Species 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- 238000011725 BALB/c mouse Methods 0.000 description 1
- 201000001178 Bacterial Pneumonia Diseases 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 241000228405 Blastomyces dermatitidis Species 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 241000222173 Candida parapsilosis Species 0.000 description 1
- 241000222178 Candida tropicalis Species 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 208000018152 Cerebral disease Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 241000223203 Coccidioides Species 0.000 description 1
- 241001522757 Coccidioides posadasii Species 0.000 description 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
- 241001522864 Cryptococcus gattii VGI Species 0.000 description 1
- 108010069514 Cyclic Peptides Proteins 0.000 description 1
- 102000001189 Cyclic Peptides Human genes 0.000 description 1
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- MKDKGLNKTMDNHY-UHFFFAOYSA-N Dimerum acid Natural products OCCC(C)=CC(=O)N(O)CCCC1NC(=O)C(CCCN(O)C(=O)C=C(C)CCO)NC1=O MKDKGLNKTMDNHY-UHFFFAOYSA-N 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 208000019872 Drug Eruptions Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010051814 Eschar Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 101150064559 FTR1 gene Proteins 0.000 description 1
- 102100035831 Filensin Human genes 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 241000223221 Fusarium oxysporum Species 0.000 description 1
- 241000427940 Fusarium solani Species 0.000 description 1
- 241000233732 Fusarium verticillioides Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010019842 Hepatomegaly Diseases 0.000 description 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- 241000228402 Histoplasma Species 0.000 description 1
- 241000228404 Histoplasma capsulatum Species 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 206010023379 Ketoacidosis Diseases 0.000 description 1
- 241000588915 Klebsiella aerogenes Species 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000008771 Lymphadenopathy Diseases 0.000 description 1
- 206010025327 Lymphopenia Diseases 0.000 description 1
- 238000000585 Mann–Whitney U test Methods 0.000 description 1
- 102000003939 Membrane transport proteins Human genes 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 241001558145 Mucor sp. Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000010195 Onychomycosis Diseases 0.000 description 1
- 208000007027 Oral Candidiasis Diseases 0.000 description 1
- 102100037214 Orotidine 5'-phosphate decarboxylase Human genes 0.000 description 1
- 108010055012 Orotidine-5'-phosphate decarboxylase Proteins 0.000 description 1
- 206010033661 Pancytopenia Diseases 0.000 description 1
- 241001537205 Paracoccidioides Species 0.000 description 1
- 241000526686 Paracoccidioides brasiliensis Species 0.000 description 1
- 206010033767 Paracoccidioides infections Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 241000235645 Pichia kudriavzevii Species 0.000 description 1
- 206010067565 Pneumonia cryptococcal Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000029464 Pulmonary infiltrates Diseases 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 206010037868 Rash maculo-papular Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000257028 Rhizopus delemar Type II NRRL 21446 Species 0.000 description 1
- 241000257030 Rhizopus delemar Type II NRRL 21447 Species 0.000 description 1
- 241000257016 Rhizopus delemar Type II NRRL 21477 Species 0.000 description 1
- 241000593344 Rhizopus microsporus Species 0.000 description 1
- 241000257013 Rhizopus oryzae 99-133 Species 0.000 description 1
- 241000257014 Rhizopus oryzae HUMC 02 Species 0.000 description 1
- 241000257003 Rhizopus oryzae Type I NRRL 13440 Species 0.000 description 1
- 241000257007 Rhizopus oryzae Type I NRRL 21396 Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 241001149962 Sporothrix Species 0.000 description 1
- 241001149963 Sporothrix schenckii Species 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010042938 Systemic candida Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241000287411 Turdidae Species 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 241000758405 Zoopagomycotina Species 0.000 description 1
- 241000222126 [Candida] glabrata Species 0.000 description 1
- WZGNVVUXVXNNOX-UHFFFAOYSA-N [Fe+] Chemical compound [Fe+] WZGNVVUXVXNNOX-UHFFFAOYSA-N 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000758 acidotic effect Effects 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 201000009267 bronchiectasis Diseases 0.000 description 1
- GHWVXCQZPNWFRO-UHFFFAOYSA-N butane-2,3-diamine Chemical compound CC(N)C(C)N GHWVXCQZPNWFRO-UHFFFAOYSA-N 0.000 description 1
- 208000032343 candida glabrata infection Diseases 0.000 description 1
- 229940055022 candida parapsilosis Drugs 0.000 description 1
- 229960003034 caspofungin Drugs 0.000 description 1
- JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000711 cavernous sinus Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000004700 cellular uptake Effects 0.000 description 1
- 210000003096 cerebellopontine angle Anatomy 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 201000009950 chronic meningitis Diseases 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 229940125898 compound 5 Drugs 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000002498 deadly effect Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 208000019164 disseminated candidiasis Diseases 0.000 description 1
- 208000022682 disseminated sporotrichosis Diseases 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 229940092559 enterobacter aerogenes Drugs 0.000 description 1
- 230000007159 enucleation Effects 0.000 description 1
- 231100000333 eschar Toxicity 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 201000009320 ethmoid sinusitis Diseases 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 208000001936 exophthalmos Diseases 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 229940025452 ferriprox Drugs 0.000 description 1
- 108010062616 filensin Proteins 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 208000024386 fungal infectious disease Diseases 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 229940025294 hemin Drugs 0.000 description 1
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 description 1
- 208000027700 hepatic dysfunction Diseases 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 238000007489 histopathology method Methods 0.000 description 1
- 230000009215 host defense mechanism Effects 0.000 description 1
- UCNNJGDEJXIUCC-UHFFFAOYSA-L hydroxy(oxo)iron;iron Chemical compound [Fe].O[Fe]=O.O[Fe]=O UCNNJGDEJXIUCC-UHFFFAOYSA-L 0.000 description 1
- 208000018875 hypoxemia Diseases 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000002650 immunosuppressive therapy Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000010189 intracellular transport Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229940075525 iron chelating agent Drugs 0.000 description 1
- 230000010438 iron metabolism Effects 0.000 description 1
- SGGMZBKLQLBBLK-UHFFFAOYSA-N iron(4+) Chemical compound [Fe+4] SGGMZBKLQLBBLK-UHFFFAOYSA-N 0.000 description 1
- CYCSEDRJRMCANL-UHFFFAOYSA-N iron(5+) Chemical compound [Fe+5] CYCSEDRJRMCANL-UHFFFAOYSA-N 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000030208 low-grade fever Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 206010025226 lymphangitis Diseases 0.000 description 1
- 231100001023 lymphopenia Toxicity 0.000 description 1
- 230000007434 lytic lesion Effects 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- MWNFNXOAMKFJAE-UHFFFAOYSA-N methanamine;silver Chemical compound [Ag].NC MWNFNXOAMKFJAE-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 230000003589 nefrotoxic effect Effects 0.000 description 1
- 231100000381 nephrotoxic Toxicity 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 206010030875 ophthalmoplegia Diseases 0.000 description 1
- 244000039328 opportunistic pathogen Species 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 208000021090 palsy Diseases 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000007119 pathological manifestation Effects 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 208000024796 pleuritic chest pain Diseases 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 230000001823 pruritic effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 208000011727 retrobulbar pain Diseases 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 231100000004 severe toxicity Toxicity 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 201000006923 sphenoid sinusitis Diseases 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 208000008203 tachypnea Diseases 0.000 description 1
- 206010043089 tachypnoea Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 201000005882 tinea unguium Diseases 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 231100000155 toxicity by organ Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83109906P | 2006-07-13 | 2006-07-13 | |
| US60/831,099 | 2006-07-13 | ||
| US89762007P | 2007-01-26 | 2007-01-26 | |
| US60/897,620 | 2007-01-26 | ||
| US90407507P | 2007-02-27 | 2007-02-27 | |
| US60/904,075 | 2007-02-27 | ||
| PCT/US2007/016065 WO2008008537A2 (en) | 2006-07-13 | 2007-07-13 | Combi) compositions for the treatment of mucormycosis. comprising iron chelator and antifungal agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2007272781A1 AU2007272781A1 (en) | 2008-01-17 |
| AU2007272781B2 true AU2007272781B2 (en) | 2012-10-18 |
Family
ID=38610625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007272781A Ceased AU2007272781B2 (en) | 2006-07-13 | 2007-07-13 | Combi) compositions for the treatment of mucormycosis. comprising iron chelator and antifungal agent |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20100129434A1 (enExample) |
| EP (2) | EP2043636A2 (enExample) |
| JP (2) | JP2009543788A (enExample) |
| KR (1) | KR20090036587A (enExample) |
| AU (1) | AU2007272781B2 (enExample) |
| BR (1) | BRPI0714221A2 (enExample) |
| CA (1) | CA2657634A1 (enExample) |
| CL (1) | CL2007002026A1 (enExample) |
| IL (1) | IL196389A0 (enExample) |
| MA (1) | MA30625B1 (enExample) |
| MX (1) | MX2009000506A (enExample) |
| NO (1) | NO20090565L (enExample) |
| NZ (1) | NZ574862A (enExample) |
| RU (1) | RU2464024C2 (enExample) |
| SG (1) | SG177122A1 (enExample) |
| TN (1) | TN2009000004A1 (enExample) |
| TW (1) | TWI448285B (enExample) |
| WO (1) | WO2008008537A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ614255A (en) * | 2009-03-19 | 2015-03-27 | Los Angeles Biomed Res Inst | Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases |
| US8980876B2 (en) | 2010-10-28 | 2015-03-17 | The Procter & Gamble Company | Inhibition of microbial growth by aconitase inhibition |
| MX2015003729A (es) * | 2012-11-12 | 2015-06-15 | Cipla Ltd | Composiciones farmaceuticas de dosis fija que comprende deferasirox y deferiprona. |
| US11229685B2 (en) | 2013-01-29 | 2022-01-25 | Case Western Reserve University | Fungal iron acquisition inhibitors and uses thereof |
| US20160199361A1 (en) * | 2013-08-19 | 2016-07-14 | Rutgers, The State University Of New Jersey | Method of Inducing An Anti-Retroviral Immune Response By Counter-Acting Retro-Virus Induced Anti-Apoptosis |
| US20170239182A1 (en) * | 2014-08-13 | 2017-08-24 | Mark E. Hayes | Pharmaceutical formulations of and methods to prepare chelating agents for efficient metal removal treatment systems |
| WO2016025611A2 (en) * | 2014-08-13 | 2016-02-18 | Zoneone Pharma, Inc. | Pharmaceutical formulations of chelating agents as a metal removal treatment system |
| WO2017035582A1 (en) * | 2015-08-31 | 2017-03-09 | The University Of Adelaide | Methods and products for preventing and/or treating microorganism infections comprising iron chelators and non-iron porphyrins |
| EP3454944B1 (en) * | 2016-05-13 | 2022-07-13 | The Brigham and Women's Hospital, Inc. | Volatile metabolite profiles for the diagnosis and treatment of mucorales fungi |
| FR3095755A1 (fr) * | 2019-05-10 | 2020-11-13 | Balmes Transplantation | Nouveaux médicaments cytoprotecteurs |
| CN113905715B (zh) | 2019-06-28 | 2025-04-15 | 宝洁公司 | 光增强处理方法 |
| JP2023057423A (ja) * | 2021-10-11 | 2023-04-21 | 国立大学法人 熊本大学 | ムコール症治療薬 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6165484A (en) * | 1997-08-26 | 2000-12-26 | Wake Forest University | EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections |
| WO2004045609A2 (en) * | 2002-11-19 | 2004-06-03 | Relivia Srl | Hydroxypyridinones for the local treatment of skin microcirculatory disorders |
| WO2005051411A1 (de) * | 2003-11-28 | 2005-06-09 | Biofrontera Discovery Gmbh | Neues arzneimittel oxachelin und derivate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8329043D0 (en) * | 1983-10-31 | 1983-11-30 | Hider R C | Pharmaceutical compositions |
| US4698431A (en) * | 1985-11-12 | 1987-10-06 | The United States Of America As Represented By The United States Department Of Energy | Hydroxypyridonate chelating agents |
| PH31594A (en) * | 1993-09-30 | 1998-11-03 | Janssen Pharmaceutica Nv | Oral formulations on an antifungal. |
| TW533205B (en) * | 1996-06-25 | 2003-05-21 | Novartis Ag | Substituted 3,5-diphenyl-l,2,4-triazoles and their pharmaceutical composition |
| EP1223308B1 (de) * | 2000-12-16 | 2007-01-24 | ALSTOM Technology Ltd | Komponente einer Strömungsmaschine |
| GB0223978D0 (en) | 2002-10-15 | 2002-11-20 | Novartis Ag | Organic compound |
| AU2003302274A1 (en) * | 2002-12-31 | 2004-07-29 | Novartis Ag | Aerosolizable pharmaceutical formulation for fungal infection therapy |
| WO2004108114A2 (en) * | 2003-03-31 | 2004-12-16 | Dinesh Shantilal Patel | Anti-fungal composition and a process for its manufacture |
-
2007
- 2007-07-12 TW TW096125466A patent/TWI448285B/zh not_active IP Right Cessation
- 2007-07-12 CL CL200702026A patent/CL2007002026A1/es unknown
- 2007-07-13 WO PCT/US2007/016065 patent/WO2008008537A2/en not_active Ceased
- 2007-07-13 US US12/373,511 patent/US20100129434A1/en not_active Abandoned
- 2007-07-13 RU RU2009104961/15A patent/RU2464024C2/ru not_active IP Right Cessation
- 2007-07-13 AU AU2007272781A patent/AU2007272781B2/en not_active Ceased
- 2007-07-13 JP JP2009519562A patent/JP2009543788A/ja active Pending
- 2007-07-13 MX MX2009000506A patent/MX2009000506A/es not_active Application Discontinuation
- 2007-07-13 EP EP07796874A patent/EP2043636A2/en not_active Withdrawn
- 2007-07-13 NZ NZ574862A patent/NZ574862A/en not_active IP Right Cessation
- 2007-07-13 CA CA002657634A patent/CA2657634A1/en not_active Abandoned
- 2007-07-13 BR BRPI0714221-8A patent/BRPI0714221A2/pt not_active IP Right Cessation
- 2007-07-13 KR KR1020097002793A patent/KR20090036587A/ko not_active Ceased
- 2007-07-13 EP EP11003922A patent/EP2412371A1/en not_active Withdrawn
- 2007-07-13 SG SG2011075421A patent/SG177122A1/en unknown
-
2009
- 2009-01-08 IL IL196389A patent/IL196389A0/en unknown
- 2009-01-12 TN TN2009000004A patent/TN2009000004A1/fr unknown
- 2009-02-04 MA MA31613A patent/MA30625B1/fr unknown
- 2009-02-05 NO NO20090565A patent/NO20090565L/no not_active Application Discontinuation
-
2012
- 2012-11-27 JP JP2012258262A patent/JP2013040212A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6165484A (en) * | 1997-08-26 | 2000-12-26 | Wake Forest University | EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections |
| WO2004045609A2 (en) * | 2002-11-19 | 2004-06-03 | Relivia Srl | Hydroxypyridinones for the local treatment of skin microcirculatory disorders |
| WO2005051411A1 (de) * | 2003-11-28 | 2005-06-09 | Biofrontera Discovery Gmbh | Neues arzneimittel oxachelin und derivate |
Non-Patent Citations (1)
| Title |
|---|
| MENCACCI et al. Journal of Infectious Diseases (1997) vol. 175, no. 6, pages 1467-1476 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008008537A2 (en) | 2008-01-17 |
| SG177122A1 (en) | 2012-01-30 |
| MA30625B1 (fr) | 2009-08-03 |
| EP2043636A2 (en) | 2009-04-08 |
| RU2009104961A (ru) | 2010-08-20 |
| NO20090565L (no) | 2009-03-30 |
| MX2009000506A (es) | 2009-05-20 |
| IL196389A0 (en) | 2009-09-22 |
| CA2657634A1 (en) | 2008-01-17 |
| KR20090036587A (ko) | 2009-04-14 |
| WO2008008537A3 (en) | 2008-04-24 |
| EP2412371A1 (en) | 2012-02-01 |
| BRPI0714221A2 (pt) | 2013-01-01 |
| TW200816994A (en) | 2008-04-16 |
| US20100129434A1 (en) | 2010-05-27 |
| RU2464024C2 (ru) | 2012-10-20 |
| NZ574862A (en) | 2012-02-24 |
| TWI448285B (zh) | 2014-08-11 |
| JP2009543788A (ja) | 2009-12-10 |
| TN2009000004A1 (en) | 2010-08-19 |
| JP2013040212A (ja) | 2013-02-28 |
| CL2007002026A1 (es) | 2008-06-06 |
| AU2007272781A1 (en) | 2008-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2007272781B2 (en) | Combi) compositions for the treatment of mucormycosis. comprising iron chelator and antifungal agent | |
| Hoenigl et al. | The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin | |
| Deresinski et al. | Caspofungin | |
| Moen et al. | Liposomal amphotericin B: a review of its use as empirical therapy in febrile neutropenia and in the treatment of invasive fungal infections | |
| Hossain et al. | New investigational antifungal agents for treating invasive fungal infections | |
| Leenders et al. | Liposomal amphotericin B (AmBisome) reduces dissemination of infection ad compared with amphotericin B deoxycholate (Fungizone) in a rat model of pulmonary aspergillosis | |
| Joseph et al. | Micafungin: a new echinocandin antifungal | |
| Dupont et al. | Mycoses in AIDS patients | |
| Almajid et al. | Fosmanogepix: the novel anti-fungal agent’s comprehensive review of in vitro, in vivo, and current insights from advancing clinical trials | |
| CN110290797A (zh) | 用于预防和治疗真菌感染的单剂量方法 | |
| EP2011512A1 (en) | An anti HSP90 antibody | |
| De Pauw et al. | Progress in fighting systemic fungal infections in haematological neoplasia | |
| Estes et al. | Pharmacology and antifungal properties of anidulafungin, a new echinocandin | |
| Harari | Current strategies in the treatment of invasive Aspergillus infections in immunocompromised patients | |
| Bormann et al. | Review of the pharmacology and clinical studies of micafungin | |
| US9901615B2 (en) | Method for treatment of gastric ulcers | |
| Pagano et al. | Zygomycosis: current approaches to management of patients with haematological malignancies | |
| CN101301289A (zh) | 小檗碱及其结构类似物在逆转多药耐药泵中的应用 | |
| Saoulidis et al. | Antifungal activity of posaconazole and granulocyte colony‐stimulating factor in the treatment of disseminated zygomycosis (mucormycosis) in a neutropaenic murine model | |
| US20220160631A1 (en) | Antifungal nanoparticles for targeted treatment of fungal infections | |
| TWI712410B (zh) | 艾曲波帕用於製備抗隱球菌藥物之用途 | |
| CN101511360A (zh) | 用于毛霉病和其它真菌疾病治疗的组合物及方法 | |
| US20090131366A1 (en) | Use of Amine-Borane Compounds as Anti-Microbial Agents | |
| Flattery et al. | New model of oropharyngeal and gastrointestinal colonization by Candida albicans in CD4+ T-cell-deficient mice for evaluation of antifungal agents | |
| Sahu et al. | Mucormycosis in Indian COVID-19 patients: Insight into its patho-genesis, clinical manifestation, and management strategies. Antibiotics (Basel) 2021; 10: 1079 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |