AU2007230989A1 - Methods and compositions for treating hypercholesterolemia and atherosclerosis - Google Patents

Methods and compositions for treating hypercholesterolemia and atherosclerosis Download PDF

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Publication number
AU2007230989A1
AU2007230989A1 AU2007230989A AU2007230989A AU2007230989A1 AU 2007230989 A1 AU2007230989 A1 AU 2007230989A1 AU 2007230989 A AU2007230989 A AU 2007230989A AU 2007230989 A AU2007230989 A AU 2007230989A AU 2007230989 A1 AU2007230989 A1 AU 2007230989A1
Authority
AU
Australia
Prior art keywords
compound
formula
atherosclerosis
treating
hypercholesterolemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2007230989A
Other languages
English (en)
Inventor
Gokhan S. Hotamisligil
Umut Ozcan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of AU2007230989A1 publication Critical patent/AU2007230989A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2007230989A 2006-03-22 2007-03-22 Methods and compositions for treating hypercholesterolemia and atherosclerosis Abandoned AU2007230989A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78515606P 2006-03-22 2006-03-22
US60/785,156 2006-03-22
PCT/US2007/007225 WO2007111992A2 (en) 2006-03-22 2007-03-22 Methods and compositions for treating hypercholesterolemia and atherosclerosis

Publications (1)

Publication Number Publication Date
AU2007230989A1 true AU2007230989A1 (en) 2007-10-04

Family

ID=38541674

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007230989A Abandoned AU2007230989A1 (en) 2006-03-22 2007-03-22 Methods and compositions for treating hypercholesterolemia and atherosclerosis

Country Status (7)

Country Link
US (1) US20090312297A1 (enExample)
EP (1) EP2001484A4 (enExample)
JP (1) JP2009530398A (enExample)
CN (1) CN101534641A (enExample)
AU (1) AU2007230989A1 (enExample)
CA (1) CA2679608A1 (enExample)
WO (1) WO2007111992A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008024374A2 (en) * 2006-08-22 2008-02-28 Jain Mahendra K Inhibitors of pancreatic phospholipase a2 for altering cholesterol and fat uptake
JP2009078977A (ja) * 2007-09-25 2009-04-16 Japan Health Science Foundation 心筋の小胞体ストレス抑制剤
KR101064937B1 (ko) * 2009-06-16 2011-09-15 박상규 타우로우루소데옥시콜릭산 또는 그의 염을 포함하는 혈관재협착 예방 또는 치료용 약학 조성물
EP2599481A1 (en) * 2011-11-30 2013-06-05 Lunamed AG 4-phenylbutyric acid for the treatment or prevention of various diseases
US9872865B2 (en) 2013-03-24 2018-01-23 Amylyx Pharmaceuticals Inc. Compositions for improving cell viability and methods of use thereof
WO2014160877A1 (en) * 2013-03-27 2014-10-02 Metselex, Inc. Prevention and treatment of kidney damage by bile acids
JP6430736B2 (ja) * 2014-03-20 2018-11-28 株式会社ファンケル 新規ステロール系化合物およびこれを含有するコレステロール吸収阻害剤
CN103919787A (zh) * 2014-04-17 2014-07-16 厦门大学 牛磺熊脱氧胆酸及其可接受的盐的制药用途
CA2963980A1 (en) * 2014-10-15 2016-04-21 Burke & Boyer Nyc Monounsaturated fatty acid compositions and use for treating atherosclerosis
KR101555945B1 (ko) 2014-11-27 2015-09-25 부산대학교 산학협력단 Ｔｕｄｃａ를 이용한 줄기세포 생물작용 활성 증가, 및 이를 포함하는 줄기세포 치료 보조제
US20180235919A1 (en) * 2015-02-06 2018-08-23 Lonza Inc. System and Method For Treating Atheroma Formation
ES2905872T3 (es) 2015-02-06 2022-04-12 Intercept Pharmaceuticals Inc Composiciones farmacéuticas para terapia combinada
SG10201912756XA (en) * 2016-02-26 2020-02-27 Gemphire Therapeutics Inc Treatment of patients with homozygous familial hypercholesterolemia on lipid lowering therapy
PL3522927T3 (pl) * 2017-10-02 2021-06-28 The Procter & Gamble Company Sposoby hamowania przemiany choliny w trimetyloaminę (tma)
CN110279702B (zh) * 2019-07-18 2022-09-02 西安交通大学医学院第一附属医院 胆汁酸衍生物在防治动脉粥样硬化药物中的应用
CN110559303B (zh) * 2019-09-24 2023-06-02 江西天元药业有限公司 降血脂预防治疗心脑血管病和动脉粥样硬化的精制熊胆粉
US11583542B2 (en) 2019-12-16 2023-02-21 Amylyx Pharmaceuticals, Inc. Compositions of bile acids and phenylbutyrate compounds
KR102686453B1 (ko) * 2021-08-18 2024-07-17 전북대학교산학협력단 TUDCA 코팅된 나노입자 및 이를 포함하는 p-셀렉틴 리간드, p-셀렉틴 과발현 질병 치료용 조성물 및 진단용 영상 조영제
US12138272B2 (en) 2022-05-12 2024-11-12 Amylyx Pharmaceuticals, Inc. Methods and compositions for treating amyotrophic lateral sclerosis
WO2025054199A1 (en) * 2023-09-05 2025-03-13 Amylyx Pharmaceuticals, Inc. Compositions and methods for treating subjects with hepatic impairment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68769A (en) * 1983-05-23 1986-02-28 Hadassah Med Org Pharmaceutical compositions containing insulin for oral administration
IT1213390B (it) * 1986-11-28 1989-12-20 Gipharmex Spa Composizioni farmaceutiche ad uso orale del tipo a cessione controllata nel tempo contenenti composti a struttura steroidea attivi nelle alterazioni del metabolismo del colesterolo.
EP0773029A4 (en) * 1993-07-19 1997-09-03 Tokyo Tanabe Co HEPATITIS C VIRUS PROLIFERATION INHIBITOR
US6270954B1 (en) * 1996-04-10 2001-08-07 The Regents Of The University Of California Correction of genetic defects using chemical chaperones
WO1999026657A1 (en) * 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
AU2003275495A1 (en) * 2002-11-07 2004-06-03 Walter C. Low Methods of treating injuries of the nervous system associated with hemorrhage
WO2006069371A1 (en) * 2004-12-22 2006-06-29 Baylor College Of Medicine A method of plasma lipidation to prevent, inhibit and/or reverse atherosclerosis

Also Published As

Publication number Publication date
CN101534641A (zh) 2009-09-16
WO2007111992A3 (en) 2008-11-06
US20090312297A1 (en) 2009-12-17
WO2007111992A2 (en) 2007-10-04
EP2001484A4 (en) 2010-04-21
JP2009530398A (ja) 2009-08-27
CA2679608A1 (en) 2007-10-04
EP2001484A2 (en) 2008-12-17

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted