AU2006313701B2 - Novel pyridopyrazines and their use as modulators of kinases - Google Patents
Novel pyridopyrazines and their use as modulators of kinases Download PDFInfo
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- AU2006313701B2 AU2006313701B2 AU2006313701A AU2006313701A AU2006313701B2 AU 2006313701 B2 AU2006313701 B2 AU 2006313701B2 AU 2006313701 A AU2006313701 A AU 2006313701A AU 2006313701 A AU2006313701 A AU 2006313701A AU 2006313701 B2 AU2006313701 B2 AU 2006313701B2
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- alkyl
- heterocyclyl
- pyrido
- disorders
- compound
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- A61P9/12—Antihypertensives
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
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Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
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US73569805P | 2005-11-11 | 2005-11-11 | |
US60/735,698 | 2005-11-11 | ||
EP05024693.3 | 2005-11-11 | ||
EP05024693A EP1785423A1 (de) | 2005-11-11 | 2005-11-11 | Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen |
US84976106P | 2006-10-06 | 2006-10-06 | |
US60/849,761 | 2006-10-06 | ||
PCT/EP2006/068322 WO2007054556A1 (de) | 2005-11-11 | 2006-11-10 | Neue pyridopyrazine und deren verwendung als modulatoren von kinasen |
Publications (2)
Publication Number | Publication Date |
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AU2006313701A1 AU2006313701A1 (en) | 2007-05-18 |
AU2006313701B2 true AU2006313701B2 (en) | 2012-05-31 |
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AU2006313701A Ceased AU2006313701B2 (en) | 2005-11-11 | 2006-11-10 | Novel pyridopyrazines and their use as modulators of kinases |
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EP (1) | EP1957487A1 (de) |
JP (1) | JP5527972B2 (de) |
KR (1) | KR101400905B1 (de) |
AR (1) | AR060010A1 (de) |
AU (1) | AU2006313701B2 (de) |
CA (1) | CA2628039A1 (de) |
HK (1) | HK1126474A1 (de) |
IL (1) | IL191139A0 (de) |
NO (1) | NO20082511L (de) |
WO (1) | WO2007054556A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
EP1990342A1 (de) * | 2007-05-10 | 2008-11-12 | AEterna Zentaris GmbH | Pyridopyrazin-Derivate sowie Herstellungs- und Verwendungsverfahren dafür |
EP2170338A2 (de) * | 2007-07-06 | 2010-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dna-pkcs zur modulierung von energieregulation und gehirnfunktion |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
US8846723B2 (en) | 2010-07-29 | 2014-09-30 | Eastman Chemical Company | Esters of O-substituted hydroxy carboxylic acids and preparations thereof |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
EP2508184A1 (de) | 2011-04-06 | 2012-10-10 | Æterna Zentaris GmbH | Pyridopyrazinderivate und ihre Verwendungen |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
WO2015144808A1 (en) | 2014-03-26 | 2015-10-01 | Astex Therapeutics Ltd | Combinations of an fgfr inhibitor and an igf1r inhibitor |
SI3122358T1 (sl) | 2014-03-26 | 2021-04-30 | Astex Therapeutics Ltd. | Kombinacije FGFR- in CMET-inhibitorjev za zdravljenje raka |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
ES2904513T3 (es) | 2015-09-23 | 2022-04-05 | Janssen Pharmaceutica Nv | 1,4-Benzodiazepinas biheteroarilo sustituidas y usos de las mismas para el tratamiento del cáncer |
BR112018005637B1 (pt) | 2015-09-23 | 2023-11-28 | Janssen Pharmaceutica Nv | Compostos derivados de quinoxalina, quinolina e quinazolinona,composições farmacêuticas que os compreende, e uso dos referidos compostos |
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WO2004104003A1 (de) * | 2003-05-23 | 2004-12-02 | Zentaris Gmbh | Neue pyridopyrazine und deren verwendung als modulatoren von kinasen |
WO2004104002A1 (de) * | 2003-05-23 | 2004-12-02 | Zentaris Gmbh | Neue pyridopyrazine und deren verwendung als kinase-inhibitoren |
WO2005007099A2 (en) * | 2003-07-10 | 2005-01-27 | Imclone Systems Incorporated | Pkb inhibitors as anti-tumor agents |
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US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
CA2172750A1 (en) | 1995-03-28 | 1996-09-29 | Shinzo Seko | Process for producing aminonitropyridines |
UA71555C2 (en) | 1997-10-06 | 2004-12-15 | Zentaris Gmbh | Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives |
ES2154253T3 (es) | 1997-12-22 | 2012-01-27 | Bayer Healthcare Llc | Inhibición de la actividad de p38 cinasa usando ureas heterocíclicas sustituidas. |
JP2002532414A (ja) | 1998-12-15 | 2002-10-02 | ワーナー−ランバート・カンパニー | 移植片拒絶反応を防止するためのmek阻害剤の使用 |
KR20010099877A (ko) | 1998-12-22 | 2001-11-09 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 배합물 화학요법 |
US6518277B1 (en) | 2000-04-25 | 2003-02-11 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
DK1301472T3 (da) | 2000-07-19 | 2014-04-07 | Warner Lambert Co | Oxygenerede estere af 4-iod-phenylamino-benzhydroxamsyrer |
WO2003024448A2 (en) | 2001-09-14 | 2003-03-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US20040023961A1 (en) | 2002-02-11 | 2004-02-05 | Bayer Corporation | Aryl ureas with raf kinase and angiogenisis inhibiting activity |
EP1496981A2 (de) | 2002-04-08 | 2005-01-19 | Merck & Co., Inc. | Verfahren zur behandlung von krebs |
AU2003230802B2 (en) | 2002-04-08 | 2007-08-09 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
EP1496896A4 (de) | 2002-04-08 | 2007-10-31 | Merck & Co Inc | Akt-wirkungshemmer |
AU2003281340B2 (en) | 2002-07-02 | 2009-04-09 | Southern Research Institute | Inhibitors of FtsZ and uses thereof |
WO2004017950A2 (en) | 2002-08-22 | 2004-03-04 | Piramed Limited | Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents |
CN1816543B (zh) * | 2003-06-05 | 2011-01-19 | 赞塔里斯有限公司 | 具有细胞凋亡诱导效应的吲哚衍生物 |
WO2005056547A2 (en) | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
EP1790342A1 (de) * | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
-
2006
- 2006-11-10 KR KR1020087014068A patent/KR101400905B1/ko not_active IP Right Cessation
- 2006-11-10 EP EP06819385A patent/EP1957487A1/de not_active Withdrawn
- 2006-11-10 CA CA002628039A patent/CA2628039A1/en not_active Abandoned
- 2006-11-10 WO PCT/EP2006/068322 patent/WO2007054556A1/de active Application Filing
- 2006-11-10 AU AU2006313701A patent/AU2006313701B2/en not_active Ceased
- 2006-11-10 JP JP2008539443A patent/JP5527972B2/ja not_active Expired - Fee Related
- 2006-11-13 AR ARP060104949A patent/AR060010A1/es unknown
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2008
- 2008-04-29 IL IL191139A patent/IL191139A0/en unknown
- 2008-06-03 NO NO20082511A patent/NO20082511L/no not_active Application Discontinuation
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- 2009-05-26 HK HK09104745.1A patent/HK1126474A1/en not_active IP Right Cessation
Patent Citations (3)
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WO2004104003A1 (de) * | 2003-05-23 | 2004-12-02 | Zentaris Gmbh | Neue pyridopyrazine und deren verwendung als modulatoren von kinasen |
WO2004104002A1 (de) * | 2003-05-23 | 2004-12-02 | Zentaris Gmbh | Neue pyridopyrazine und deren verwendung als kinase-inhibitoren |
WO2005007099A2 (en) * | 2003-07-10 | 2005-01-27 | Imclone Systems Incorporated | Pkb inhibitors as anti-tumor agents |
Also Published As
Publication number | Publication date |
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JP5527972B2 (ja) | 2014-06-25 |
AU2006313701A1 (en) | 2007-05-18 |
EP1957487A1 (de) | 2008-08-20 |
HK1126474A1 (en) | 2009-09-04 |
IL191139A0 (en) | 2008-12-29 |
KR20080068117A (ko) | 2008-07-22 |
CA2628039A1 (en) | 2007-05-18 |
AR060010A1 (es) | 2008-05-21 |
WO2007054556A1 (de) | 2007-05-18 |
JP2009515853A (ja) | 2009-04-16 |
KR101400905B1 (ko) | 2014-05-29 |
NO20082511L (no) | 2008-06-24 |
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