AU2006222060B2 - Roflumilast for the treatment of diabetes mellitus - Google Patents
Roflumilast for the treatment of diabetes mellitus Download PDFInfo
- Publication number
- AU2006222060B2 AU2006222060B2 AU2006222060A AU2006222060A AU2006222060B2 AU 2006222060 B2 AU2006222060 B2 AU 2006222060B2 AU 2006222060 A AU2006222060 A AU 2006222060A AU 2006222060 A AU2006222060 A AU 2006222060A AU 2006222060 B2 AU2006222060 B2 AU 2006222060B2
- Authority
- AU
- Australia
- Prior art keywords
- roflumilast
- diabetes mellitus
- oxide
- pharmaceutically acceptable
- mellitus type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title claims abstract description 143
- 229960002586 roflumilast Drugs 0.000 title claims abstract description 137
- 238000011282 treatment Methods 0.000 title claims abstract description 93
- 206010012601 diabetes mellitus Diseases 0.000 title abstract description 48
- PCGSQNPMMSALEJ-UHFFFAOYSA-N roflumilast n-oxide Chemical compound ClC1=C[N+]([O-])=CC(Cl)=C1NC(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 PCGSQNPMMSALEJ-UHFFFAOYSA-N 0.000 claims abstract description 135
- 150000003839 salts Chemical class 0.000 claims description 159
- 201000000083 maturity-onset diabetes of the young type 1 Diseases 0.000 claims description 146
- 239000008194 pharmaceutical composition Substances 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 12
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 6
- DGMMTKATQKRXOP-UHFFFAOYSA-N 2-(3,5-dichloropyridin-4-yl)benzamide Chemical compound NC(=O)C1=CC=CC=C1C1=C(Cl)C=NC=C1Cl DGMMTKATQKRXOP-UHFFFAOYSA-N 0.000 claims description 2
- VZPZDGJXBPXAFF-UHFFFAOYSA-N ClC=1C=[N+](C=C(C1C1=C(C(=O)N)C=CC=C1)Cl)[O-] Chemical compound ClC=1C=[N+](C=C(C1C1=C(C(=O)N)C=CC=C1)Cl)[O-] VZPZDGJXBPXAFF-UHFFFAOYSA-N 0.000 claims description 2
- GWRSATNRNFYMDI-UHFFFAOYSA-N 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8h-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-n-(1-methylpiperidin-4-yl)benzamide Chemical compound FC=1C=C(NC=2N=C3N(C4CCCC4)CC(F)(F)C(=O)N(C)C3=CN=2)C(OC)=CC=1C(=O)NC1CCN(C)CC1 GWRSATNRNFYMDI-UHFFFAOYSA-N 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 18
- 239000013543 active substance Substances 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 description 129
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 72
- 235000013350 formula milk Nutrition 0.000 description 66
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 59
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- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 27
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- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 description 20
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- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 20
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- WPGGHFDDFPHPOB-BBWFWOEESA-N mitiglinide Chemical compound C([C@@H](CC(=O)N1C[C@@H]2CCCC[C@@H]2C1)C(=O)O)C1=CC=CC=C1 WPGGHFDDFPHPOB-BBWFWOEESA-N 0.000 description 12
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- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 11
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- JLRGJRBPOGGCBT-UHFFFAOYSA-N Tolbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 JLRGJRBPOGGCBT-UHFFFAOYSA-N 0.000 description 10
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05101772 | 2005-03-08 | ||
| EP05101772.1 | 2005-03-08 | ||
| PCT/EP2006/060418 WO2006094933A1 (en) | 2005-03-08 | 2006-03-03 | Roflumilast for the treatment of diabetes mellitus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2011253752A Division AU2011253752A1 (en) | 2005-03-08 | 2011-11-30 | Roflumilast for the treatment of diabetes mellitus |
Publications (2)
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| AU2006222060A1 AU2006222060A1 (en) | 2006-09-14 |
| AU2006222060B2 true AU2006222060B2 (en) | 2011-09-01 |
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| EP (1) | EP1874308A1 (enExample) |
| JP (2) | JP5091106B2 (enExample) |
| KR (1) | KR101302838B1 (enExample) |
| CN (2) | CN101137368B (enExample) |
| AU (1) | AU2006222060B2 (enExample) |
| BR (1) | BRPI0609371A2 (enExample) |
| CA (1) | CA2599376C (enExample) |
| EA (1) | EA015382B1 (enExample) |
| IL (2) | IL185277A (enExample) |
| MX (1) | MX2007010560A (enExample) |
| NO (1) | NO20074943L (enExample) |
| NZ (1) | NZ560269A (enExample) |
| WO (1) | WO2006094933A1 (enExample) |
| ZA (1) | ZA200706294B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE409057T1 (de) | 2002-02-11 | 2008-10-15 | Antares Pharma Inc | Intradermales injektionsgerät |
| JP5216328B2 (ja) | 2005-01-24 | 2013-06-19 | アンタレス ファーマ インコーポレイテッド | あらかじめ充填された針補助シリンジジェット式注射器 |
| CN101137368B (zh) * | 2005-03-08 | 2012-05-16 | 奈科明有限责任公司 | 治疗糖尿病的罗氟司特 |
| TW200738266A (en) * | 2005-09-29 | 2007-10-16 | Sankyo Co | Pharmaceutical agent containing insulin resistance improving agent |
| WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
| WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| AU2007293885A1 (en) * | 2006-09-07 | 2008-03-13 | Takeda Gmbh | Combination treatment for diabetes mellitus |
| ES2752152T3 (es) | 2008-03-10 | 2020-04-03 | Antares Pharma Inc | Dispositivo de seguridad para inyector |
| CN101548972B (zh) * | 2008-04-03 | 2012-10-17 | 万特制药(海南)有限公司 | 一种含有瑞格列奈的固体药物组合物 |
| ES2738539T3 (es) | 2008-08-05 | 2020-01-23 | Antares Pharma Inc | Inyector de dosis múltiples |
| EP4427737A3 (en) | 2009-03-20 | 2024-11-20 | Antares Pharma, Inc. | Hazardous agent injection system |
| US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
| US20130172303A1 (en) * | 2012-01-03 | 2013-07-04 | Forest Laboratories Holdings Ltd. | Roflumilast compositions for the treatment of copd |
| US9486583B2 (en) | 2012-03-06 | 2016-11-08 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
| CN104487114A (zh) | 2012-04-06 | 2015-04-01 | 安塔雷斯药品公司 | 针头辅助喷射注射给予睾酮组合物 |
| WO2013169804A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
| ES2969984T3 (es) | 2013-02-11 | 2024-05-23 | Antares Pharma Inc | Dispositivo de inyección por chorro asistido por aguja que tiene fuerza de disparo reducida |
| WO2014124860A1 (en) | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Specific pde4b-inhibitors for the treatment of diabetes mellitus |
| WO2014164786A1 (en) * | 2013-03-11 | 2014-10-09 | Madsen Patrick | Dosage injector with pinion system |
| WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
| EP3165224A1 (en) * | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| CN109328193A (zh) | 2016-04-19 | 2019-02-12 | 尤瑞卡有限公司 | 肽-低聚脲折叠体化合物及其使用方法 |
| GB202306663D0 (en) * | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
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-
2006
- 2006-03-03 CN CN2006800072465A patent/CN101137368B/zh not_active Expired - Fee Related
- 2006-03-03 KR KR1020077022434A patent/KR101302838B1/ko not_active Expired - Fee Related
- 2006-03-03 NZ NZ560269A patent/NZ560269A/en not_active IP Right Cessation
- 2006-03-03 EA EA200701845A patent/EA015382B1/ru not_active IP Right Cessation
- 2006-03-03 CA CA2599376A patent/CA2599376C/en not_active Expired - Fee Related
- 2006-03-03 AU AU2006222060A patent/AU2006222060B2/en not_active Ceased
- 2006-03-03 CN CN2012100579547A patent/CN102600144A/zh active Pending
- 2006-03-03 EP EP06708617A patent/EP1874308A1/en not_active Withdrawn
- 2006-03-03 US US11/885,450 patent/US8017633B2/en not_active Expired - Fee Related
- 2006-03-03 WO PCT/EP2006/060418 patent/WO2006094933A1/en not_active Ceased
- 2006-03-03 BR BRPI0609371-0A patent/BRPI0609371A2/pt not_active IP Right Cessation
- 2006-03-03 MX MX2007010560A patent/MX2007010560A/es not_active Application Discontinuation
- 2006-03-03 JP JP2008500172A patent/JP5091106B2/ja not_active Expired - Fee Related
-
2007
- 2007-07-27 ZA ZA200706294A patent/ZA200706294B/xx unknown
- 2007-08-14 IL IL185277A patent/IL185277A/en not_active IP Right Cessation
- 2007-10-01 NO NO20074943A patent/NO20074943L/no not_active Application Discontinuation
-
2011
- 2011-07-11 US US13/179,895 patent/US8541456B2/en not_active Expired - Fee Related
-
2012
- 2012-06-07 JP JP2012129982A patent/JP5611275B2/ja not_active Expired - Fee Related
- 2012-07-18 IL IL221006A patent/IL221006A0/en unknown
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712298A (en) * | 1993-07-02 | 1998-01-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors |
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| US20020002191A1 (en) * | 2000-05-25 | 2002-01-03 | Richard Friesen | Fluoroalkoxy-substituted benzamide dichloropyridinyl N-oxide PDE4 inhibitor |
| US20030186974A1 (en) * | 2001-01-31 | 2003-10-02 | Anthony Marfat | Pyrrolyl- and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes |
| US20050049258A1 (en) * | 2001-01-31 | 2005-03-03 | Pfizer Inc | Ether derivatives useful as inhibitors of PDE4 isozymes |
| US20030069169A1 (en) * | 2001-03-02 | 2003-04-10 | Macor John E. | Co-administration of melanocortin receptor agonist and phosphodiesterase inhibitor for treatment of cyclic-AMP associated disorders |
| WO2004067006A1 (en) * | 2003-01-27 | 2004-08-12 | Pharmacia Corporation | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
| WO2004103407A2 (en) * | 2003-05-22 | 2004-12-02 | Altana Pharma Ag | Composition comprising a pde4 inhibitor and a pde5 inhibitor |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ560269A (en) | 2010-12-24 |
| CA2599376A1 (en) | 2006-09-14 |
| JP5611275B2 (ja) | 2014-10-22 |
| JP2008532974A (ja) | 2008-08-21 |
| NO20074943L (no) | 2007-10-01 |
| EA200701845A1 (ru) | 2008-02-28 |
| US8017633B2 (en) | 2011-09-13 |
| CA2599376C (en) | 2014-05-13 |
| CN101137368B (zh) | 2012-05-16 |
| US20110269750A1 (en) | 2011-11-03 |
| KR20070111539A (ko) | 2007-11-21 |
| HK1116077A1 (en) | 2008-12-19 |
| MX2007010560A (es) | 2008-02-21 |
| EP1874308A1 (en) | 2008-01-09 |
| BRPI0609371A2 (pt) | 2010-03-30 |
| ZA200706294B (en) | 2008-09-25 |
| JP5091106B2 (ja) | 2012-12-05 |
| KR101302838B1 (ko) | 2013-09-03 |
| US8541456B2 (en) | 2013-09-24 |
| CN102600144A (zh) | 2012-07-25 |
| EA015382B1 (ru) | 2011-08-30 |
| AU2006222060A1 (en) | 2006-09-14 |
| US20080214625A1 (en) | 2008-09-04 |
| JP2012188448A (ja) | 2012-10-04 |
| IL221006A0 (en) | 2012-08-30 |
| IL185277A (en) | 2013-08-29 |
| CN101137368A (zh) | 2008-03-05 |
| IL185277A0 (en) | 2008-02-09 |
| WO2006094933A1 (en) | 2006-09-14 |
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