AU2005304112B2 - Potent LNA oligonucleotides for the inhibition of HIF-1a expression - Google Patents

Potent LNA oligonucleotides for the inhibition of HIF-1a expression Download PDF

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Publication number
AU2005304112B2
AU2005304112B2 AU2005304112A AU2005304112A AU2005304112B2 AU 2005304112 B2 AU2005304112 B2 AU 2005304112B2 AU 2005304112 A AU2005304112 A AU 2005304112A AU 2005304112 A AU2005304112 A AU 2005304112A AU 2005304112 B2 AU2005304112 B2 AU 2005304112B2
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AU
Australia
Prior art keywords
lna
seq
effective amount
cells
cancer
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Ceased
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AU2005304112A
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AU2005304112A1 (en
Inventor
Henrik Frydenlund Hansen
Frank Winther Rasmussen
Charlotte Albaek Thrue
Majken Westergaard
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Roche Innovation Center Copenhagen AS
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Santaris Pharma AS
Enzon Pharmaceuticals Inc
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Application filed by Santaris Pharma AS, Enzon Pharmaceuticals Inc filed Critical Santaris Pharma AS
Publication of AU2005304112A1 publication Critical patent/AU2005304112A1/en
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Publication of AU2005304112B2 publication Critical patent/AU2005304112B2/en
Assigned to ENZON PHARMACEUTICALS, INC., SANTARIS PHARMA A/S reassignment ENZON PHARMACEUTICALS, INC. Request for Assignment Assignors: SANTARIS PHARMA A/S
Assigned to ROCHE INNOVATION CENTER COPENHAGEN A/S reassignment ROCHE INNOVATION CENTER COPENHAGEN A/S Request to Amend Deed and Register Assignors: SANTARIS PHARMA A/S
Assigned to SANTARIS PHARMA A/S reassignment SANTARIS PHARMA A/S Request for Assignment Assignors: ENZON PHARMACEUTICALS, INC., SANTARIS PHARMA A/S
Anticipated expiration legal-status Critical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005304112A 2004-11-09 2005-11-09 Potent LNA oligonucleotides for the inhibition of HIF-1a expression Ceased AU2005304112B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US62656304P 2004-11-09 2004-11-09
US60/626,563 2004-11-09
US64718605P 2005-01-25 2005-01-25
US60/647,186 2005-01-25
US69972105P 2005-07-15 2005-07-15
US60/699,721 2005-07-15
US72462105P 2005-10-07 2005-10-07
US60/724,621 2005-10-07
PCT/DK2005/000721 WO2006050734A2 (en) 2004-11-09 2005-11-09 Potent lna oligonucleotides for the inhibition of hif-1a expression

Publications (2)

Publication Number Publication Date
AU2005304112A1 AU2005304112A1 (en) 2006-05-18
AU2005304112B2 true AU2005304112B2 (en) 2009-06-04

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ID=36177326

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Application Number Title Priority Date Filing Date
AU2005304112A Ceased AU2005304112B2 (en) 2004-11-09 2005-11-09 Potent LNA oligonucleotides for the inhibition of HIF-1a expression

Country Status (16)

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US (3) US7589190B2 (enExample)
EP (1) EP1833840B9 (enExample)
JP (3) JP4825807B2 (enExample)
KR (1) KR101176245B1 (enExample)
AT (1) ATE476441T1 (enExample)
AU (1) AU2005304112B2 (enExample)
BR (1) BRPI0515726A8 (enExample)
CA (1) CA2587173C (enExample)
DE (1) DE602005022768D1 (enExample)
DK (1) DK1833840T3 (enExample)
EA (1) EA014097B1 (enExample)
IL (1) IL183054A0 (enExample)
MX (1) MX2007005558A (enExample)
NO (1) NO341878B1 (enExample)
NZ (1) NZ555644A (enExample)
WO (1) WO2006050734A2 (enExample)

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