AU2005299440B2 - Melanocortin receptor binding mimetibodies, compositions, methods and uses - Google Patents
Melanocortin receptor binding mimetibodies, compositions, methods and uses Download PDFInfo
- Publication number
- AU2005299440B2 AU2005299440B2 AU2005299440A AU2005299440A AU2005299440B2 AU 2005299440 B2 AU2005299440 B2 AU 2005299440B2 AU 2005299440 A AU2005299440 A AU 2005299440A AU 2005299440 A AU2005299440 A AU 2005299440A AU 2005299440 B2 AU2005299440 B2 AU 2005299440B2
- Authority
- AU
- Australia
- Prior art keywords
- polypeptide
- seq
- cell
- melanocortin receptor
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000004378 Melanocortin Receptors Human genes 0.000 title claims abstract 8
- 108090000950 Melanocortin Receptors Proteins 0.000 title claims abstract 8
- 238000000034 method Methods 0.000 title claims abstract 7
- 239000000203 mixture Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims abstract 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 20
- 102000040430 polynucleotide Human genes 0.000 claims abstract 9
- 108091033319 polynucleotide Proteins 0.000 claims abstract 9
- 239000002157 polynucleotide Substances 0.000 claims abstract 9
- 230000001404 mediated effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000008316 Type 4 Melanocortin Receptor Human genes 0.000 claims 1
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62196004P | 2004-10-25 | 2004-10-25 | |
| US60/621,960 | 2004-10-25 | ||
| PCT/US2005/038431 WO2006047535A2 (en) | 2004-10-25 | 2005-10-25 | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2005299440A1 AU2005299440A1 (en) | 2006-05-04 |
| AU2005299440B2 true AU2005299440B2 (en) | 2011-12-15 |
Family
ID=36228385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005299440A Ceased AU2005299440B2 (en) | 2004-10-25 | 2005-10-25 | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20060105951A1 (enExample) |
| EP (1) | EP1812046B1 (enExample) |
| JP (1) | JP2008517605A (enExample) |
| KR (1) | KR101255140B1 (enExample) |
| CN (1) | CN101437540B (enExample) |
| AT (1) | ATE501731T1 (enExample) |
| AU (1) | AU2005299440B2 (enExample) |
| BR (1) | BRPI0518411A2 (enExample) |
| CA (1) | CA2585287A1 (enExample) |
| CY (1) | CY1111486T1 (enExample) |
| DE (1) | DE602005026970D1 (enExample) |
| DK (1) | DK1812046T3 (enExample) |
| EA (1) | EA200700944A1 (enExample) |
| EC (1) | ECSP077416A (enExample) |
| ES (1) | ES2363023T3 (enExample) |
| HR (1) | HRP20110405T1 (enExample) |
| IL (1) | IL182683A0 (enExample) |
| MA (1) | MA28943B1 (enExample) |
| ME (1) | ME01234B (enExample) |
| MX (1) | MX2007004974A (enExample) |
| NO (1) | NO20072499L (enExample) |
| PL (1) | PL1812046T3 (enExample) |
| PT (1) | PT1812046E (enExample) |
| RS (1) | RS51789B (enExample) |
| SI (1) | SI1812046T1 (enExample) |
| TN (1) | TNSN07157A1 (enExample) |
| WO (1) | WO2006047535A2 (enExample) |
| ZA (1) | ZA200704260B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7910101B2 (en) * | 2004-10-25 | 2011-03-22 | Centocor, Inc. | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
| US7790671B2 (en) * | 2005-10-07 | 2010-09-07 | Codman & Shurtleff, Inc. | Implantable pump for protein delivery for obesity control by drug infusion into the brain |
| CA2727317C (en) | 2008-06-09 | 2015-02-17 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptides for treatment of sexual dysfunction |
| US20090305960A1 (en) * | 2008-06-09 | 2009-12-10 | Palatin Technologies, Inc | Melanocortin Receptor-Specific Peptides for Treatment of Obesity / 669 |
| US8614185B2 (en) * | 2009-05-04 | 2013-12-24 | Centocor Ortho Biotech Inc. | Fusion proteins of alpha-MSH derivatives and Fc |
| WO2010144341A2 (en) | 2009-06-08 | 2010-12-16 | Palatin Technologies, Inc. | Lactam-bridged melanocortin receptor-specific peptides |
| UY32690A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Péptidos específicos para receptores de melanocortina |
| CA2761607C (en) | 2009-06-08 | 2018-09-04 | Yi-Qun Shi | Melanocortin receptor-specific peptides |
| CA2781402C (en) | 2009-11-23 | 2017-03-21 | Palatin Technologies, Inc. | Melanocortin-1 receptor-specific cyclic peptides |
| EA201290295A1 (ru) | 2009-11-23 | 2013-01-30 | Палатин Текнолоджиз, Инк. | Специфичные к рецептору меланокортина-1 линейные пептиды |
| JP2020141710A (ja) * | 2011-07-06 | 2020-09-10 | ゲンマブ エー／エス | 抗体重鎖のｃ末端の修飾による補体依存性細胞傷害の調節 |
| CN113272330B (zh) * | 2019-03-02 | 2024-07-26 | 南通壹宸生物医药科技有限公司 | 一种双特异抗体 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000033658A1 (en) * | 1998-12-09 | 2000-06-15 | Eleanor Roosevelt Institute | Composition and method for regulation of body weight and associated conditions |
| WO2002006316A2 (en) * | 2000-07-14 | 2002-01-24 | Zycos, Inc. | Alpha-msh related compounds and methods of use |
| WO2004002424A2 (en) * | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1545608A4 (en) * | 2002-06-28 | 2006-09-13 | Centocor Inc | CH1-DELETED MAMMED MUICETIC BODIES, COMPOSITIONS, METHODS AND APPLICATIONS |
| CA2563379A1 (en) * | 2004-03-31 | 2005-10-20 | Centocor, Inc. | Human glp-1 mimetibodies, compositions, methods and uses |
-
2005
- 2005-10-25 KR KR1020077011487A patent/KR101255140B1/ko not_active Expired - Fee Related
- 2005-10-25 ME MEP-2011-85A patent/ME01234B/me unknown
- 2005-10-25 CN CN2005800447902A patent/CN101437540B/zh not_active Expired - Fee Related
- 2005-10-25 JP JP2007538172A patent/JP2008517605A/ja active Pending
- 2005-10-25 MX MX2007004974A patent/MX2007004974A/es unknown
- 2005-10-25 EA EA200700944A patent/EA200700944A1/ru unknown
- 2005-10-25 PL PL05819741T patent/PL1812046T3/pl unknown
- 2005-10-25 AT AT05819741T patent/ATE501731T1/de active
- 2005-10-25 DE DE602005026970T patent/DE602005026970D1/de not_active Expired - Lifetime
- 2005-10-25 RS RS20110230A patent/RS51789B/sr unknown
- 2005-10-25 ES ES05819741T patent/ES2363023T3/es not_active Expired - Lifetime
- 2005-10-25 AU AU2005299440A patent/AU2005299440B2/en not_active Ceased
- 2005-10-25 BR BRPI0518411-8A patent/BRPI0518411A2/pt not_active IP Right Cessation
- 2005-10-25 WO PCT/US2005/038431 patent/WO2006047535A2/en not_active Ceased
- 2005-10-25 EP EP05819741A patent/EP1812046B1/en not_active Expired - Lifetime
- 2005-10-25 PT PT05819741T patent/PT1812046E/pt unknown
- 2005-10-25 HR HR20110405T patent/HRP20110405T1/hr unknown
- 2005-10-25 US US11/257,851 patent/US20060105951A1/en not_active Abandoned
- 2005-10-25 DK DK05819741.9T patent/DK1812046T3/da active
- 2005-10-25 CA CA002585287A patent/CA2585287A1/en not_active Abandoned
- 2005-10-25 SI SI200531295T patent/SI1812046T1/sl unknown
-
2007
- 2007-04-19 IL IL182683A patent/IL182683A0/en unknown
- 2007-04-23 MA MA29843A patent/MA28943B1/fr unknown
- 2007-04-24 TN TNP2007000157A patent/TNSN07157A1/fr unknown
- 2007-04-25 EC EC2007007416A patent/ECSP077416A/es unknown
- 2007-05-15 NO NO20072499A patent/NO20072499L/no not_active Application Discontinuation
- 2007-05-24 ZA ZA200704260A patent/ZA200704260B/xx unknown
-
2011
- 2011-05-23 CY CY20111100502T patent/CY1111486T1/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000033658A1 (en) * | 1998-12-09 | 2000-06-15 | Eleanor Roosevelt Institute | Composition and method for regulation of body weight and associated conditions |
| WO2002006316A2 (en) * | 2000-07-14 | 2002-01-24 | Zycos, Inc. | Alpha-msh related compounds and methods of use |
| WO2004002424A2 (en) * | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |