CA2585287A1 - Melanocortin receptor binding mimetibodies, compositions, methods and uses - Google Patents

Melanocortin receptor binding mimetibodies, compositions, methods and uses Download PDF

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Publication number
CA2585287A1
CA2585287A1 CA002585287A CA2585287A CA2585287A1 CA 2585287 A1 CA2585287 A1 CA 2585287A1 CA 002585287 A CA002585287 A CA 002585287A CA 2585287 A CA2585287 A CA 2585287A CA 2585287 A1 CA2585287 A1 CA 2585287A1
Authority
CA
Canada
Prior art keywords
seq
polypeptide
cell
alpha
mimetibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002585287A
Other languages
English (en)
French (fr)
Inventor
Mark Cunningham
Vedrana Stojanovic-Susulic
Karyn O'neil
Chichi Huang
Jeffrey Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2585287A1 publication Critical patent/CA2585287A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68Melanocyte-stimulating hormone [MSH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1796Receptors; Cell surface antigens; Cell surface determinants for hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/27Growth hormone [GH], i.e. somatotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002585287A 2004-10-25 2005-10-25 Melanocortin receptor binding mimetibodies, compositions, methods and uses Abandoned CA2585287A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62196004P 2004-10-25 2004-10-25
US60/621,960 2004-10-25
PCT/US2005/038431 WO2006047535A2 (en) 2004-10-25 2005-10-25 Melanocortin receptor binding mimetibodies, compositions, methods and uses

Publications (1)

Publication Number Publication Date
CA2585287A1 true CA2585287A1 (en) 2006-05-04

Family

ID=36228385

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002585287A Abandoned CA2585287A1 (en) 2004-10-25 2005-10-25 Melanocortin receptor binding mimetibodies, compositions, methods and uses

Country Status (28)

Country Link
US (1) US20060105951A1 (enExample)
EP (1) EP1812046B1 (enExample)
JP (1) JP2008517605A (enExample)
KR (1) KR101255140B1 (enExample)
CN (1) CN101437540B (enExample)
AT (1) ATE501731T1 (enExample)
AU (1) AU2005299440B2 (enExample)
BR (1) BRPI0518411A2 (enExample)
CA (1) CA2585287A1 (enExample)
CY (1) CY1111486T1 (enExample)
DE (1) DE602005026970D1 (enExample)
DK (1) DK1812046T3 (enExample)
EA (1) EA200700944A1 (enExample)
EC (1) ECSP077416A (enExample)
ES (1) ES2363023T3 (enExample)
HR (1) HRP20110405T1 (enExample)
IL (1) IL182683A0 (enExample)
MA (1) MA28943B1 (enExample)
ME (1) ME01234B (enExample)
MX (1) MX2007004974A (enExample)
NO (1) NO20072499L (enExample)
PL (1) PL1812046T3 (enExample)
PT (1) PT1812046E (enExample)
RS (1) RS51789B (enExample)
SI (1) SI1812046T1 (enExample)
TN (1) TNSN07157A1 (enExample)
WO (1) WO2006047535A2 (enExample)
ZA (1) ZA200704260B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910101B2 (en) * 2004-10-25 2011-03-22 Centocor, Inc. Melanocortin receptor binding mimetibodies, compositions, methods and uses
US7790671B2 (en) * 2005-10-07 2010-09-07 Codman & Shurtleff, Inc. Implantable pump for protein delivery for obesity control by drug infusion into the brain
AU2009257631B2 (en) 2008-06-09 2014-07-24 Palatin Technologies, Inc. Melanocortin receptor-specific peptides for treatment of sexual dysfunction
AR072072A1 (es) * 2008-06-09 2010-08-04 Palatin Technologies Inc Peptidos especificos del receptor de melanocortina para el tratamiento de la obesidad / 669
US8614185B2 (en) * 2009-05-04 2013-12-24 Centocor Ortho Biotech Inc. Fusion proteins of alpha-MSH derivatives and Fc
WO2010144341A2 (en) 2009-06-08 2010-12-16 Palatin Technologies, Inc. Lactam-bridged melanocortin receptor-specific peptides
UY32690A (es) 2009-06-08 2011-01-31 Astrazeneca Ab Péptidos específicos para receptores de melanocortina
CN105037502A (zh) 2009-06-08 2015-11-11 帕拉丁科技公司 黑皮质素受体特异性肽
WO2011063366A1 (en) 2009-11-23 2011-05-26 Palatin Technologies, Inc. Melanocortin-1 receptor-specific cyclic peptides
KR20120102716A (ko) 2009-11-23 2012-09-18 팔라틴 테크놀로지스 인코포레이티드 멜라노코르틴-1 수용체 특이적 선형 펩티드
JP2020141710A (ja) * 2011-07-06 2020-09-10 ゲンマブ エー/エス 抗体重鎖のc末端の修飾による補体依存性細胞傷害の調節
CN113272330B (zh) * 2019-03-02 2024-07-26 南通壹宸生物医药科技有限公司 一种双特异抗体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000033658A1 (en) 1998-12-09 2000-06-15 Eleanor Roosevelt Institute Composition and method for regulation of body weight and associated conditions
AU2001275930B2 (en) * 2000-07-14 2007-05-10 Eisai Inc. Alpha-msh related compounds and methods of use
AU2003256336A1 (en) * 2002-06-28 2004-01-19 Centocor, Inc. Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses
EP1545608A4 (en) * 2002-06-28 2006-09-13 Centocor Inc CH1-DELETED MAMMED MUICETIC BODIES, COMPOSITIONS, METHODS AND APPLICATIONS
EA011583B1 (ru) * 2004-03-31 2009-04-28 Сентокор, Инк. Миметические антитела glp-1 человека, композиции, способы и применения

Also Published As

Publication number Publication date
IL182683A0 (en) 2007-09-20
ZA200704260B (en) 2009-03-25
TNSN07157A1 (en) 2008-11-21
CY1111486T1 (el) 2015-08-05
KR101255140B1 (ko) 2013-04-22
WO2006047535A2 (en) 2006-05-04
AU2005299440B2 (en) 2011-12-15
MA28943B1 (fr) 2007-10-01
CN101437540A (zh) 2009-05-20
US20060105951A1 (en) 2006-05-18
MX2007004974A (es) 2007-10-17
WO2006047535A3 (en) 2008-09-04
SI1812046T1 (sl) 2011-06-30
DE602005026970D1 (de) 2011-04-28
ME01234B (me) 2013-06-20
ES2363023T3 (es) 2011-07-19
KR20070085416A (ko) 2007-08-27
BRPI0518411A2 (pt) 2008-11-18
EA200700944A1 (ru) 2008-04-28
ATE501731T1 (de) 2011-04-15
HRP20110405T1 (hr) 2011-06-30
DK1812046T3 (da) 2011-06-06
AU2005299440A1 (en) 2006-05-04
CN101437540B (zh) 2012-12-19
EP1812046B1 (en) 2011-03-16
JP2008517605A (ja) 2008-05-29
HK1106445A1 (en) 2008-03-14
ECSP077416A (es) 2007-05-30
RS51789B (sr) 2011-12-31
EP1812046A2 (en) 2007-08-01
PT1812046E (pt) 2011-06-28
EP1812046A4 (en) 2009-11-11
PL1812046T3 (pl) 2011-08-31
NO20072499L (no) 2007-07-16

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued