AU2005268775A1 - Prodrugs activated by RNA-dependent DNA-polymerases - Google Patents

Prodrugs activated by RNA-dependent DNA-polymerases Download PDF

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Publication number
AU2005268775A1
AU2005268775A1 AU2005268775A AU2005268775A AU2005268775A1 AU 2005268775 A1 AU2005268775 A1 AU 2005268775A1 AU 2005268775 A AU2005268775 A AU 2005268775A AU 2005268775 A AU2005268775 A AU 2005268775A AU 2005268775 A1 AU2005268775 A1 AU 2005268775A1
Authority
AU
Australia
Prior art keywords
compound
cytotoxic
deoxy
rna
dependent dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2005268775A
Other languages
English (en)
Inventor
Ivano Bertini
Massimo Calamante
Claudio Luchinat
Alessandro Mordini
Alessandro Quattrone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protera SRL
Original Assignee
Protera SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protera SRL filed Critical Protera SRL
Publication of AU2005268775A1 publication Critical patent/AU2005268775A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2005268775A 2004-08-03 2005-08-02 Prodrugs activated by RNA-dependent DNA-polymerases Abandoned AU2005268775A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000173A ITFI20040173A1 (it) 2004-08-03 2004-08-03 Profarmaci attivati da dna polimerasi dipendenti da rna
ITFI2004A000173 2004-08-03
PCT/EP2005/053765 WO2006013203A2 (en) 2004-08-03 2005-08-02 Prodrugs activated by rna-dependent dna-polymerases

Publications (1)

Publication Number Publication Date
AU2005268775A1 true AU2005268775A1 (en) 2006-02-09

Family

ID=35589591

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005268775A Abandoned AU2005268775A1 (en) 2004-08-03 2005-08-02 Prodrugs activated by RNA-dependent DNA-polymerases

Country Status (8)

Country Link
US (1) US8110676B2 (https=)
EP (1) EP1778254A2 (https=)
JP (1) JP2008509110A (https=)
CN (1) CN101031308A (https=)
AU (1) AU2005268775A1 (https=)
CA (1) CA2575520A1 (https=)
IT (1) ITFI20040173A1 (https=)
WO (1) WO2006013203A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
CN102014919B (zh) * 2008-03-03 2015-02-25 托斯克公司 减少毒性的甲氨蝶呤佐剂及其使用方法
EP3578563B1 (en) 2011-12-22 2021-04-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
US20190100553A1 (en) * 2016-04-12 2019-04-04 The Board Of Trustees Of The Leland Stanford Junior University Direct activity assays and compositions for nucleotide pool sanitizing enzymes
US20250002524A1 (en) * 2021-07-30 2025-01-02 CureVac SE Cap analogs having an acyclic linker to the guanine derivative nucleobase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880000094B1 (ko) * 1984-12-07 1988-02-23 보령제약 주식회사 뉴클레오시드 유도체의 제조방법
JPH0920792A (ja) * 1995-07-11 1997-01-21 Soyaku Gijutsu Kenkyusho:Kk ヌクレオチドダイマー
WO2003072757A2 (en) * 2002-02-28 2003-09-04 Biota, Inc. Nucleotide mimics and their prodrugs
CA2512484A1 (en) * 2003-01-16 2004-05-08 Hybridon, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides

Also Published As

Publication number Publication date
US20080300215A1 (en) 2008-12-04
EP1778254A2 (en) 2007-05-02
JP2008509110A (ja) 2008-03-27
CA2575520A1 (en) 2006-02-09
CN101031308A (zh) 2007-09-05
US8110676B2 (en) 2012-02-07
WO2006013203A3 (en) 2006-07-27
ITFI20040173A1 (it) 2004-11-03
WO2006013203A2 (en) 2006-02-09

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted