CN101031308A - 由rna依赖性dna聚合酶活化的药物前体 - Google Patents

由rna依赖性dna聚合酶活化的药物前体 Download PDF

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Publication number
CN101031308A
CN101031308A CNA2005800260597A CN200580026059A CN101031308A CN 101031308 A CN101031308 A CN 101031308A CN A2005800260597 A CNA2005800260597 A CN A2005800260597A CN 200580026059 A CN200580026059 A CN 200580026059A CN 101031308 A CN101031308 A CN 101031308A
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CN
China
Prior art keywords
chemical compound
group
cytotoxic
compound
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800260597A
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English (en)
Chinese (zh)
Inventor
伊迈诺·贝尔蒂尼
克劳迪奥·鲁奇耐特
阿尔桑德罗·夸冲
马西默·克来门特
阿尔桑德罗·莫迪尼
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Protera SRL
Original Assignee
Protera SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protera SRL filed Critical Protera SRL
Publication of CN101031308A publication Critical patent/CN101031308A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
CNA2005800260597A 2004-08-03 2005-08-02 由rna依赖性dna聚合酶活化的药物前体 Pending CN101031308A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000173A ITFI20040173A1 (it) 2004-08-03 2004-08-03 Profarmaci attivati da dna polimerasi dipendenti da rna
ITFI2004A000173 2004-08-03

Publications (1)

Publication Number Publication Date
CN101031308A true CN101031308A (zh) 2007-09-05

Family

ID=35589591

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800260597A Pending CN101031308A (zh) 2004-08-03 2005-08-02 由rna依赖性dna聚合酶活化的药物前体

Country Status (8)

Country Link
US (1) US8110676B2 (https=)
EP (1) EP1778254A2 (https=)
JP (1) JP2008509110A (https=)
CN (1) CN101031308A (https=)
AU (1) AU2005268775A1 (https=)
CA (1) CA2575520A1 (https=)
IT (1) ITFI20040173A1 (https=)
WO (1) WO2006013203A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014919B (zh) * 2008-03-03 2015-02-25 托斯克公司 减少毒性的甲氨蝶呤佐剂及其使用方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
EP3578563B1 (en) 2011-12-22 2021-04-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
US20190100553A1 (en) * 2016-04-12 2019-04-04 The Board Of Trustees Of The Leland Stanford Junior University Direct activity assays and compositions for nucleotide pool sanitizing enzymes
US20250002524A1 (en) * 2021-07-30 2025-01-02 CureVac SE Cap analogs having an acyclic linker to the guanine derivative nucleobase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880000094B1 (ko) * 1984-12-07 1988-02-23 보령제약 주식회사 뉴클레오시드 유도체의 제조방법
JPH0920792A (ja) * 1995-07-11 1997-01-21 Soyaku Gijutsu Kenkyusho:Kk ヌクレオチドダイマー
WO2003072757A2 (en) * 2002-02-28 2003-09-04 Biota, Inc. Nucleotide mimics and their prodrugs
CA2512484A1 (en) * 2003-01-16 2004-05-08 Hybridon, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014919B (zh) * 2008-03-03 2015-02-25 托斯克公司 减少毒性的甲氨蝶呤佐剂及其使用方法

Also Published As

Publication number Publication date
US20080300215A1 (en) 2008-12-04
EP1778254A2 (en) 2007-05-02
JP2008509110A (ja) 2008-03-27
CA2575520A1 (en) 2006-02-09
US8110676B2 (en) 2012-02-07
WO2006013203A3 (en) 2006-07-27
ITFI20040173A1 (it) 2004-11-03
AU2005268775A1 (en) 2006-02-09
WO2006013203A2 (en) 2006-02-09

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SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20070905