ITFI20040173A1 - Profarmaci attivati da dna polimerasi dipendenti da rna - Google Patents

Profarmaci attivati da dna polimerasi dipendenti da rna

Info

Publication number
ITFI20040173A1
ITFI20040173A1 IT000173A ITFI20040173A ITFI20040173A1 IT FI20040173 A1 ITFI20040173 A1 IT FI20040173A1 IT 000173 A IT000173 A IT 000173A IT FI20040173 A ITFI20040173 A IT FI20040173A IT FI20040173 A1 ITFI20040173 A1 IT FI20040173A1
Authority
IT
Italy
Prior art keywords
rna
dependent polymerase
activated dna
dna drugs
drugs
Prior art date
Application number
IT000173A
Other languages
English (en)
Italian (it)
Inventor
Ivano Bertini
Massimo Calamante
Claudio Luchinat
Alessandro Quattrone
Original Assignee
Protera S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protera S R L filed Critical Protera S R L
Priority to IT000173A priority Critical patent/ITFI20040173A1/it
Publication of ITFI20040173A1 publication Critical patent/ITFI20040173A1/it
Priority to CNA2005800260597A priority patent/CN101031308A/zh
Priority to US11/659,269 priority patent/US8110676B2/en
Priority to EP05779043A priority patent/EP1778254A2/en
Priority to JP2007524340A priority patent/JP2008509110A/ja
Priority to CA002575520A priority patent/CA2575520A1/en
Priority to PCT/EP2005/053765 priority patent/WO2006013203A2/en
Priority to AU2005268775A priority patent/AU2005268775A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
IT000173A 2004-08-03 2004-08-03 Profarmaci attivati da dna polimerasi dipendenti da rna ITFI20040173A1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT000173A ITFI20040173A1 (it) 2004-08-03 2004-08-03 Profarmaci attivati da dna polimerasi dipendenti da rna
CNA2005800260597A CN101031308A (zh) 2004-08-03 2005-08-02 由rna依赖性dna聚合酶活化的药物前体
US11/659,269 US8110676B2 (en) 2004-08-03 2005-08-02 Prodrugs activated by RNA-dependent DNA-polymerases
EP05779043A EP1778254A2 (en) 2004-08-03 2005-08-02 Prodrugs activated by rna-dependent dna-polymerases
JP2007524340A JP2008509110A (ja) 2004-08-03 2005-08-02 Ｒｎａ依存性ｄｎａポリメラーゼで活性化されるプロドラッグ
CA002575520A CA2575520A1 (en) 2004-08-03 2005-08-02 Prodrugs activated by rna-dependent dna-polymerases
PCT/EP2005/053765 WO2006013203A2 (en) 2004-08-03 2005-08-02 Prodrugs activated by rna-dependent dna-polymerases
AU2005268775A AU2005268775A1 (en) 2004-08-03 2005-08-02 Prodrugs activated by RNA-dependent DNA-polymerases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000173A ITFI20040173A1 (it) 2004-08-03 2004-08-03 Profarmaci attivati da dna polimerasi dipendenti da rna

Publications (1)

Publication Number Publication Date
ITFI20040173A1 true ITFI20040173A1 (it) 2004-11-03

Family

ID=35589591

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000173A ITFI20040173A1 (it) 2004-08-03 2004-08-03 Profarmaci attivati da dna polimerasi dipendenti da rna

Country Status (8)

Country Link
US (1) US8110676B2 (https=)
EP (1) EP1778254A2 (https=)
JP (1) JP2008509110A (https=)
CN (1) CN101031308A (https=)
AU (1) AU2005268775A1 (https=)
CA (1) CA2575520A1 (https=)
IT (1) ITFI20040173A1 (https=)
WO (1) WO2006013203A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
CN102014919B (zh) * 2008-03-03 2015-02-25 托斯克公司 减少毒性的甲氨蝶呤佐剂及其使用方法
EP3578563B1 (en) 2011-12-22 2021-04-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
US20190100553A1 (en) * 2016-04-12 2019-04-04 The Board Of Trustees Of The Leland Stanford Junior University Direct activity assays and compositions for nucleotide pool sanitizing enzymes
US20250002524A1 (en) * 2021-07-30 2025-01-02 CureVac SE Cap analogs having an acyclic linker to the guanine derivative nucleobase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880000094B1 (ko) * 1984-12-07 1988-02-23 보령제약 주식회사 뉴클레오시드 유도체의 제조방법
JPH0920792A (ja) * 1995-07-11 1997-01-21 Soyaku Gijutsu Kenkyusho:Kk ヌクレオチドダイマー
WO2003072757A2 (en) * 2002-02-28 2003-09-04 Biota, Inc. Nucleotide mimics and their prodrugs
CA2512484A1 (en) * 2003-01-16 2004-05-08 Hybridon, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides

Also Published As

Publication number Publication date
US20080300215A1 (en) 2008-12-04
EP1778254A2 (en) 2007-05-02
JP2008509110A (ja) 2008-03-27
CA2575520A1 (en) 2006-02-09
CN101031308A (zh) 2007-09-05
US8110676B2 (en) 2012-02-07
WO2006013203A3 (en) 2006-07-27
AU2005268775A1 (en) 2006-02-09
WO2006013203A2 (en) 2006-02-09

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