AU2005265031A1 - Modified release formulation of memantine - Google Patents
Modified release formulation of memantine Download PDFInfo
- Publication number
- AU2005265031A1 AU2005265031A1 AU2005265031A AU2005265031A AU2005265031A1 AU 2005265031 A1 AU2005265031 A1 AU 2005265031A1 AU 2005265031 A AU2005265031 A AU 2005265031A AU 2005265031 A AU2005265031 A AU 2005265031A AU 2005265031 A1 AU2005265031 A1 AU 2005265031A1
- Authority
- AU
- Australia
- Prior art keywords
- dosage form
- modified release
- oral dosage
- solid oral
- release solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000000203 mixture Substances 0.000 title description 126
- 238000009472 formulation Methods 0.000 title description 94
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 title description 80
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 36
- 239000004480 active ingredient Substances 0.000 claims description 33
- LDDHMLJTFXJGPI-UHFFFAOYSA-N memantine hydrochloride Chemical compound Cl.C1C(C2)CC3(C)CC1(C)CC2(N)C3 LDDHMLJTFXJGPI-UHFFFAOYSA-N 0.000 claims description 25
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US (9) | US8039009B2 (https=) |
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| JP (1) | JP2008503475A (https=) |
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| BR (1) | BRPI0512177A (https=) |
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| IL (1) | IL179991A0 (https=) |
| MX (1) | MXPA06014587A (https=) |
| WO (1) | WO2006009769A1 (https=) |
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| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| US20060002999A1 (en) | 2004-06-17 | 2006-01-05 | Forest Laboratories, Inc. | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane |
| TW200616608A (en) * | 2004-07-09 | 2006-06-01 | Forest Laboratories | Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients |
| US7619007B2 (en) * | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| US20060205822A1 (en) * | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| ATE481096T1 (de) | 2005-04-06 | 2010-10-15 | Adamas Pharmaceuticals Inc | Verfahren und zusammensetzungen zur behandlung von zns-erkrankungen |
| EP1898890A1 (en) * | 2005-06-16 | 2008-03-19 | Forest Laboratories, Inc. | Modified and immediate release memantine bead formulation |
| WO2007041643A1 (en) * | 2005-10-03 | 2007-04-12 | University Of Tennessee Research Foundation | Dietary calcium for reducing the production of reactive oxygen species |
| US20070141148A1 (en) * | 2005-11-30 | 2007-06-21 | Merz Pharma Gmbh & Co. Kgaa | Neramexane MR matrix tablet |
| EP2040676A2 (en) * | 2006-07-06 | 2009-04-01 | Forest Laboratories, Inc. | Orally dissolving formulations of memantine |
| GB0623897D0 (en) * | 2006-11-30 | 2007-01-10 | Pliva Istrazivanje I Razvoj D | Pharmaceutical composition of memantine |
| US20080182908A1 (en) * | 2007-01-25 | 2008-07-31 | Vinita Umashankar Vyas | Pharmaceutical compositions comprising memantine |
| CN113143901A (zh) | 2007-03-22 | 2021-07-23 | 纽罗森特里亚股份有限公司 | 镁组合物及其用途 |
| TW200916091A (en) * | 2007-06-08 | 2009-04-16 | Merz Pharma Gmbh & Amp Co Kgaa | Neramexane for the treatment of nystagmus |
| US20100292341A1 (en) * | 2007-06-29 | 2010-11-18 | Orchid Chemicals & Pharmaceuticals Limited | Quick dissolve compositions of memantine hydrochloride |
| WO2009084017A2 (en) | 2007-10-10 | 2009-07-09 | Rubicon Research Private Limited | Taste-masked orally disintegrating tablets of memantine hydrochloride |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| WO2010112221A1 (en) | 2009-04-03 | 2010-10-07 | Synthon B.V. | Pharmaceutical compositions comprising memantine |
| AU2010300475A1 (en) | 2009-09-30 | 2012-05-03 | The Regents Of The University Of California | Cofactors and methods for use for individuals |
| CA2994873A1 (en) * | 2009-12-02 | 2011-06-09 | Adamas Pharma, Llc | Amantadine compositions and methods of use |
| EP2627323A4 (en) | 2010-10-12 | 2014-03-12 | Univ Johns Hopkins | HUSTENSTILLENDE COMPOSITIONS WITH MEMANTINE |
| US20140004189A1 (en) * | 2011-01-25 | 2014-01-02 | Cadila Healthcare Limited | Modified release pharmaceutical compositions memantine |
| TR201104108A2 (tr) | 2011-04-27 | 2011-08-22 | Ali̇ Rai̇f İlaç Sanayi̇ A.Ş. | Uzatılmış salımlı memantin tablet. |
| RU2631597C2 (ru) | 2011-07-15 | 2017-09-25 | Нусерт Сайенсиз, Инк. | Композиции и способы модулирования метаболических путей |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| RU2488388C1 (ru) * | 2012-05-24 | 2013-07-27 | Ооо "Валента Интеллект" | Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств |
| CN103417483B (zh) * | 2012-05-25 | 2017-09-12 | 杭州赛利药物研究所有限公司 | 盐酸美金刚缓释干混悬剂及其制备方法 |
| WO2014015047A1 (en) | 2012-07-17 | 2014-01-23 | The General Hospital Corporation | Compositions and methods to treat neurodegenerative diseases |
| ES2623176T3 (es) * | 2012-08-16 | 2017-07-10 | Teva Pharmaceutical Industries Ltd. | Composición farmacéutica de memantina |
| RU2559776C2 (ru) * | 2012-08-20 | 2015-08-10 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Фармацевтические композиции для лечения цереброваскулярных расстройств и способы их изготовления |
| UA107653U (uk) | 2012-10-01 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів |
| SG10201709195TA (en) | 2012-11-13 | 2017-12-28 | Nusirt Sciences Inc | Compositions and methods for increasing energy metabolism |
| WO2014113404A1 (en) | 2013-01-15 | 2014-07-24 | Nusirt Sciences, Inc. | Treating pulmonary conditions |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
| PE20160605A1 (es) * | 2013-07-30 | 2016-07-20 | Gilead Connecticut Inc | Formulaciones de inhibidores de la syk |
| TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
| KR20160119863A (ko) | 2014-02-27 | 2016-10-14 | 뉴서트 사이언시스, 인크. | 간 지방증의 감소 또는 예방을 위한 조성물 및 방법 |
| MX395015B (es) | 2014-12-12 | 2025-03-24 | Ojai Energetics Pbc | Composiciones microencapsuladas de cannabinoides |
| US10350165B2 (en) | 2014-12-12 | 2019-07-16 | Ojai Energetics Pbc | Methods and systems for forming stable droplets |
| JP6707471B2 (ja) * | 2015-01-26 | 2020-06-10 | 第一三共株式会社 | ピロールカルボキサミドの固形組成物 |
| US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| SG10201913990RA (en) | 2015-10-16 | 2020-03-30 | Abbvie Inc | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| CN105412047A (zh) * | 2015-12-03 | 2016-03-23 | 烟台东诚药业集团股份有限公司 | 一种骨架型盐酸美金刚缓释胶囊及其制备方法 |
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-
2005
- 2005-06-16 EA EA200700049A patent/EA011446B1/ru not_active IP Right Cessation
- 2005-06-16 JP JP2007516725A patent/JP2008503475A/ja active Pending
- 2005-06-16 MX MXPA06014587A patent/MXPA06014587A/es not_active Application Discontinuation
- 2005-06-16 CA CA002569015A patent/CA2569015A1/en not_active Abandoned
- 2005-06-16 CN CNA200580019805XA patent/CN1968684A/zh active Pending
- 2005-06-16 EP EP05760426A patent/EP1781261A1/en not_active Withdrawn
- 2005-06-16 US US11/155,330 patent/US8039009B2/en active Active
- 2005-06-16 AU AU2005265031A patent/AU2005265031A1/en not_active Abandoned
- 2005-06-16 BR BRPI0512177-9A patent/BRPI0512177A/pt not_active IP Right Cessation
- 2005-06-16 WO PCT/US2005/021260 patent/WO2006009769A1/en not_active Ceased
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2006
- 2006-12-11 IL IL179991A patent/IL179991A0/en unknown
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2011
- 2011-09-15 US US13/233,381 patent/US20120004318A1/en not_active Abandoned
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2012
- 2012-09-14 US US13/618,014 patent/US20130012593A1/en not_active Abandoned
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2013
- 2013-07-23 US US13/948,438 patent/US20130310460A1/en not_active Abandoned
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2014
- 2014-03-28 US US14/228,944 patent/US20140213659A1/en not_active Abandoned
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2015
- 2015-01-28 US US14/607,526 patent/US20150148427A1/en not_active Abandoned
- 2015-05-27 US US14/722,538 patent/US20150258031A1/en not_active Abandoned
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2016
- 2016-07-20 US US15/215,456 patent/US10660868B2/en not_active Expired - Lifetime
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2020
- 2020-04-17 US US16/852,158 patent/US20200268685A1/en not_active Abandoned
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| US20130012593A1 (en) | 2013-01-10 |
| WO2006009769A1 (en) | 2006-01-26 |
| US20200268685A1 (en) | 2020-08-27 |
| US20130310460A1 (en) | 2013-11-21 |
| US10660868B2 (en) | 2020-05-26 |
| CA2569015A1 (en) | 2006-01-26 |
| IL179991A0 (en) | 2007-05-15 |
| EA200700049A1 (ru) | 2007-04-27 |
| MXPA06014587A (es) | 2007-04-27 |
| EA011446B1 (ru) | 2009-02-27 |
| US20150258031A1 (en) | 2015-09-17 |
| US8039009B2 (en) | 2011-10-18 |
| JP2008503475A (ja) | 2008-02-07 |
| US20140213659A1 (en) | 2014-07-31 |
| US20060051416A1 (en) | 2006-03-09 |
| BRPI0512177A (pt) | 2008-02-12 |
| US20160324803A1 (en) | 2016-11-10 |
| EP1781261A1 (en) | 2007-05-09 |
| US20120004318A1 (en) | 2012-01-05 |
| US20150148427A1 (en) | 2015-05-28 |
| CN1968684A (zh) | 2007-05-23 |
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